Clinical trials: Glaucoma; Drugs
Glaucoma
Observational Study of How Patients Take Eye Drops
This study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation…
- Trial name
- NCT00750646
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Open Angle Glaucoma, Ocular Hypertension
A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China
This is a Phase III Study that includes a single arm, open-label, multi-dose PK study cohort and a randomized, evaluator-masked, active drug-control multicenter study.
- Trial name
- NCT06666855
- Testing
- DE-117B Eye Drops, Latanoprost
- Where
- 24 sites in China
- Volunteers
- 345 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Open Angle Glaucoma
MINIject 636 in Patients With Open Angle Glaucoma Uncontrolled by Topical Hypotensive Medications
The study will evaluate the efficacy and safety of MINIject 636 and IOP lowering effects with or without glaucoma medications. The procedure will be a stand-alone surgery.
- Trial name
- NCT03374553
- Testing
- MINI DO636, MINI SO636
- Where
- 3 sites in Colombia, India and 1 more
- Volunteers
- 52 people
- Sponsor
- iSTAR Medical
Glaucoma
Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow
The purpose of this study will be to compare the aqueous production suppressant to aqueous outflow drugs in terms of the response to known vascular parameters.
- Trial name
- NCT01308788
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Indiana University
Open-angle Glaucoma
Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery
Evaluation of intraocular pressure (IOP) lowering effect of one iStent versus two iStents in conjunction with cataract surgery in subjects with primary open-angle glaucoma, washed out of one anti-glaucoma medication prior to…
- Trial name
- NCT01455467
- Testing
- One iStent, Two iStent
- Where
- Armenia
- Volunteers
- 79 people
- Sponsor
- Glaukos Corporation
Open-angle Glaucoma, Ocular Hypertension
Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after six weeks of treatment in Caucasian and Japanese subjects.
- Trial name
- NCT00047606
- Testing
- IOP Lowering Medications
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Ocular Hypertension
24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension
This study was designed to compare the 24-hour efficacy on intra ocular pressure (IOP) of drugs acting either on aqueous humor production ("inflow drugs") or on aqueous humor outflow ("outflow drugs") in human eyes affected by…
- Trial name
- NCT01655758
- Testing
- 0.5% timolol, timolol-dorzolamide fixed combination, Latanoprost
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Parma
Healthy
Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Long term treatment with anti-glaucomatous drugs has been shown to increase the incidence of dry eye syndrome with all known consequences such as ocular discomfort and epithelial keratitis.
- Trial name
- NCT01746602
- Testing
- Timoptic® 0.5%, Timophtal sine® 0.5%, Genteal HA®
- Where
- Austria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Medication Adherence, Glaucoma
The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program
The purpose of this research study is to test the impact of two personalized technology based programs that may help improve adherence to glaucoma medications.
- Trial name
- eyeGuide (NCT03159247)
- Testing
- eyeGuide
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Michigan
Glaucoma, Ocular Hypertension
An Evaluation of Use of Topical Ocular Hypotensive Medication by Compliance
This is an open-label study in patients who are currently using either a topical prostaglandin as sole ocular hypotensive medical therapy q.d., or a topical prostaglandin plus an adjunctive topical ocular hypotensive marketed…
- Trial name
- NCT00329095
- Testing
- travoprost, latanoprost, or bimatoprost, Additional ocular hypotensive medication
- Volunteers
- 60 people
- Sponsor
- Robin, Alan L., M.D.
Glaucoma
Effects of Anti-Glaucoma Medications on the Ocular Surface
The purpose of the study is to compare the efficacy of FDA-approved Travoprost (Travatan Z) and Latanoprost (Xalatan)as anti-glaucoma treatment.
- Trial name
- BAK (NCT01315574)
- Testing
- Travoprost, Latanoprost
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma
Effect of Antihypertensive Drugs on Glaucoma Patients
It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness.
- Trial name
- NCT04943107
- Testing
- no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glaucoma
Circadian Ocular Perfusion Pressure and Ocular Blood Flow
The purpose of this study was to compare the short term effects of two intraocular pressure (IOP) lowering medications on ocular perfusion pressure (OPP), ocular blood flow, intraocular pressure, and blood pressure in patients…
- Trial name
- NCT00800540
- Testing
- Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension, Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solution
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Alcon Research
Open-angle Glaucoma, Ocular Hypertension
A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs
The objective of the study was to evaluate whether timolol hemihydrate is more comfortable upon instillation than timolol maleate in sorbate. This was an observational study.
- Trial name
- NCT00823043
- Testing
- timolol hemihydrate, timolol maleate
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Vistakon Pharmaceuticals
Glaucoma, Open-Angle [C11.525.381.407]
iDropper Usability in Glaucoma
The purpose of this study is to evaluate the usability of a medication management support system for glaucoma patients self-administering eye drops named iDropper.
- Trial name
- NCT02031380
- Testing
- Open angle glaucoma - iDropper device
- Where
- United States
- Sponsor
- Care Team Solutions
Glaucoma
Glaucoma Exercise as Medicine Study (GEMS).
Project Summary Abstract: While lifestyle changes, particularly exercise, have been suggested to protect against damage to ganglion cells in animal models, definitive evidence demonstrating its benefits in humans is lacking.
- Trial name
- GEMS (NCT05581498)
- Testing
- Exercise, Bike exercise and muscle strength exercise.
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Glaucoma
Compliance and Administration Technique in Topical Drug Therapy of Glaucoma
Clinic-based evaluation of patients compliance with topical medications in the treatment of glaucoma. Also assessing effectiveness of delivery techniques among these patients.
- Trial name
- NCT00303121
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Toronto
Primary Open-Angle Glaucoma (POAG)
Personalized Mobile Reminders for Medication Adherence and Intraocular Pressure Control in Primary Open-Angle Glaucoma
This study evaluates whether a personalized mobile reminder program improves treatment adherence and clinical outcomes in adults with primary open-angle glaucoma (POAG) using topical antiglaucoma eye drops.
- Trial name
- M-GLAUCO (NCT07480577)
- Testing
- Digital Reminder Intervention
- Volunteers
- 84 people
- Sponsor
- Sakarya Yenikent State Hospital
Glaucoma, Monotherapy With Xalatan From 1 to 18 Months
Assessing Ocular Surface Changes After Changing Glaucoma Medications
Hypothesis: Changing to Travatan Z therapy increases the tear film break up time of subjects on Xalatan therapy presenting with ocular surface disease.
- Conditions
- Glaucoma, Monotherapy With Xalatan From 1 to 18 Months, Ocular Surface Disease
- Trial name
- NCT00554411
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver