Clinical trials: Glaucoma, completed
Primary Open Angle Glaucoma, Pigmentary Glaucoma
Minimally Invasive Micro Sclerostomy First in Man Safety and Preliminary Performance Study
The study objective is to demonstrate the safety of Minimally Invasive Micro Sclerostomy (MIMS) device for lowering elevated IOP in patients diagnosed with glaucoma.
- Conditions
- Primary Open Angle Glaucoma, Pigmentary Glaucoma, Pseudoexfoliative Glaucoma
- Trial name
- NCT02355990
- Testing
- Minimally Invasive Micro Sclerostomy
- Where
- Israel
- Volunteers
- 96 people
- Sponsor
- Sanoculis Ltd
Glaucoma, Trabeculectomy
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid.
- Conditions
- Glaucoma, Trabeculectomy, Wound Healing
- Trial name
- NCT01115218
- Testing
- Trabeculectomy
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- University of Cologne
Primary Open-Angle Glaucoma, Ocular Hypertension
An Open-label Extension Study to Evaluate the Safety of the 13 mg Bimatoprost Ocular Insert
This study evaluated the long-term (9-months) safety of the Bimatoprost Ocular Insert in participants with Glaucoma or Ocular Hypertension who completed study FSV5-004.
- Trial name
- OLE2 (NCT02537015)
- Testing
- Bimatoprost
- Where
- 9 sites in United States
- Volunteers
- 81 people
- Sponsor
- ForSight Vision5, Inc.
Open Angle Glaucoma
A First in Human Clinical Trial to Evaluate the Safety and Effectiveness of the STREAMLINE SURGICAL SYSTEM in Patients With Open-Angle Glaucoma
A prospective, nonrandomized, open label study to evaluate the safety and IOP lowering effectiveness of the Streamline Surgical System, in patients with mild-to-moderate open angle glaucoma undergoing cataract surgery.
- Trial name
- NCT05089474
- Testing
- Streamline Surgical System
- Where
- 3 sites in Costa Rica, Dominican Republic and 1 more
- Volunteers
- 45 people
- Sponsor
- New World Medical, Inc.
Primary Angle Closure
Primary Angle Closure Glaucoma and Aqueous Dynamics
The aim of the study is to determine which is the best treatment for people with cataract and primary angle closure (PAC).In PAC, apposition of the iris tissue to the drainage channels (Trabecular Meshwork-TM) of the eye results…
- Trial name
- NCT00719290
- Testing
- Phacoemulsification (Acrylic Foldable Intraocular Lens (Acrysoft)), (Healon5), Phacoemulsification and goniosynechialysis (Acrylic Foldable Intraocular Lens (Acrysoft)), (Healon5)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Ocular Surface Disease, Glaucoma
Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure
Evaluation of the safety and efficacy of hydrocortisone eye drops in the treatment of OSD (ocular surface disease) patients with and without glaucoma.
- Trial name
- NCT04536129
- Testing
- Hydrocortisone (CORTIVIS ®)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Molise
Glaucoma Capsulare, Genetic Predisposition to Disease
Genetic and Risk Factors in Exfoliation Glaucoma Patients
Prospective non-randomised cohort study enrolling patients with exfoliation glaucoma. All patients were ophthalmological examined at inclusion. Blood samples were taken for genetic analysis.
- Conditions
- Glaucoma Capsulare, Genetic Predisposition to Disease, Risk Reduction
- Trial name
- NCT06237764
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Göteborg University
Glaucoma, Rubeosis Iridis
Intraocular Bevacizumab (Avastin) for Rubeosis Iridis
Bevacizumab (Avastin®, Roche, Rio de Janeiro, Brazil) is an anti-VEGF recombinant humanized monoclonal IgG1 antibody used to treat colorectal cancers.
- Trial name
- NCT00557232
- Testing
- bevacizumab
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Instituto de Olhos de Goiania
Glaucoma
Interest in Electronic Applications for Patients With Glaucoma
To evaluation interest in use of smartphone- and tablet-based application (app) for participants with glaucoma, ocular hypertension, those at risk and their caregivers.
- Trial name
- GlaucomaApp (NCT02659709)
- Testing
- Interest in medical education through social media
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Ocular Melanoma
Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma
The reference treatment of ocular melanoma is a conservative treatment by proton therapy. Its goal is to treat the tumor while preserving the eyeball and visual acuity.
- Trial name
- PROTECT (NCT03172299)
- Testing
- Aflibercept Injection, False injection
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Open-Angle Glaucoma
A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with newly diagnosed open-angle glaucoma and subjects diagnosed with…
- Trial name
- NCT00326066
- Testing
- Glaucoma Surgery, cataract surgery only
- Where
- 9 sites in Austria, Germany and 3 more
- Volunteers
- 47 people
- Sponsor
- Glaukos Corporation
Glaucoma
A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma
This pilot study will test the preliminary efficacy and feasibility of an intervention protocol for one method of electric current stimulation, repetitive transorbital alternating current stimulation (rtACS), to treat visual…
- Trial name
- NCT03188042
- Testing
- rtACS Stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Glaucoma, Primary Open Angle
NT-501 CNTF Implant for Glaucoma: Safety, Neuroprotection and Neuroenhancement
Ciliary Neurotrophic Factor (CNTF) has been demonstrated in multiple pre-clinical models to enhance survival and regeneration of retinal ganglion cells, the retinal neurons injured in diseases like glaucoma.
- Trial name
- NCT01408472
- Testing
- NT-501 CNTF Implant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Jeffrey L Goldberg
Glaucoma, Open-angle
Non Interventional Study With Primary Open Angle Glaucoma and/or Ocular Hypertension Patients Treated With Xalacom® After Failure of Previous Antiglaucoma Therapy.
This study is designed to evaluate the safety and tolerability of Xalacom in patients with primary glaucoma
- Trial name
- NCT00801437
- Testing
- Xalacom
- Where
- 39 sites in Slovakia
- Volunteers
- 457 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma
Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
Glaucoma is a leading cause of blindness worldwide. Non-adherence to glaucoma medication, which may result in loss of vision, is known to be prevalent.
- Trial name
- NCT00454922
- Testing
- standard of care, education
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Colorado, Denver
Glaucoma, Open-Angle, Ocular Hypertension
Intraocular Pressure With Loteprednol and Dexamethasone
The purpose of this study is to compare intraocular pressure (IOP) changes after pterygium surgery among patients using loteprednol and dexamethasone during the postoperative period.
- Trial name
- NCT00781300
- Testing
- Loteprednol Etabonate 0.5%, Dexamethasone 0.1%
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Primary Open-Angle Glaucoma (POAG), Ocular Hypertension (OHT)
A Phase II Study to Evaluate the Additivity of Trabodenoson to Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering efficacy and the safety and tolerability profile of trabodenoson ophthalmic formulation compared to timolol maleate ophthalmic solution 0.5% in…
- Trial name
- NCT01917383
- Testing
- Trabodenoson, Latanoprost, Timolol
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Inotek Pharmaceuticals Corporation
Open-Angle Glaucoma, Ocular Hypertension
A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma
Hypothesis: H1: Efficacy of Duotrav will be superior to Xalacom at 24 hours post dosing when both medications are given in the morning H2: A significant proportion of patients will prefer dosing of once daily topical fixed…
- Trial name
- DVX (NCT00887029)
- Testing
- DuoTrav (travoprost-timolol ophthalmic drops), Xalacom (latanoprost-timolol ophthalmic drops)
- Where
- 2 sites in Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants Centres, Canada
Glaucoma, Ocular Hypertension (OH)
A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to determine the effect of plug placement on the efficacy, safety and duration of effect of the L-PPDS (latanoprost punctal plug delivery system).
- Trial name
- NCT01481077
- Testing
- Latanoprost-PPDS
- Where
- 11 sites in United States
- Volunteers
- 77 people
- Sponsor
- Mati Therapeutics Inc.
Glaucoma
Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy
Examine the safety, tolerability and efficacy of travoprost benzalkonium chloride (BAK) free ophthalmic solution compared to either latanoprost or bimatoprost monotherapy.
- Trial name
- NCT00444665
- Testing
- Travatan-Z
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Alcon Research