Clinical trials: Glaucoma Diagnosis
Glaucoma
SDOCT-GMPE Software
The investigators prospectively evaluate the new glaucoma premium edition (GMPE) software for spectral domain optical coherence tomography (SDOCT) and if this software is superior to the conventional one that is currently used…
- Trial name
- NCT02235454
- Testing
- SDOCT-GMPE software
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Mean Blur Ratio
Isometric Exercise in NTG
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
- Trial name
- NCT03921372
- Testing
- Isometric exercise
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Glaucoma
Post-operative Satisfaction With Glaucoma Surgery Trial
1. Investigate degree of postoperative satisfaction in county level hospital glaucoma patients. 2. Investigate the effect of educational intervention affect the degree of satisfaction in glaucoma patients. 3.
- Trial name
- NCT01726569
- Testing
- film and trained counseling, traditional counseling
- Where
- China
- Sponsor
- Sun Yat-sen University
Open-angle Glaucoma (OAG), Ocular Hypertension (OHT)
Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss.
- Trial name
- NCT07408154
- Testing
- Direct Selective laser Trabeculoplasty
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Medical University of South Carolina
Glaucoma, Cataract
Observational Study to Evaluate Long Term Outcomes for Ocular Hypertension and Glaucoma Patients Treated With the SpyGlass Bimatoprost Implant System / IOL Combination
The goal of this clinical trial is to further observe and learn if the SpyGlass Pharma Bimatoprost Implant System / IOL Combination works to treat cataracts and either ocular hypertension or glaucoma.
- Conditions
- Glaucoma, Cataract, Ocular Hypertension
- Trial name
- NCT07154810
- Where
- Honduras
- Volunteers
- 23 people
- Sponsor
- SpyGlass Pharma, Inc.
Intraocular Pressure, Glaucoma
24-hour IOP-lowering Effect of 0.01% Bimatoprost
This study will evaluate the 24-hour IOP-lowering efficacy of 0.01% bimatoprost once daily in patients with glaucoma or ocular hypertension
- Conditions
- Intraocular Pressure, Glaucoma, Ocular Hypertension
- Trial name
- NCT01271686
- Testing
- 0.01% bimatoprost
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease, Glaucoma
Prospective Electronic Polygenic Risk Study - Second Phase
This study will investigate the role of polygenic risk scores (PRS) in preventive health.
- Trial name
- PEPRS2 (NCT05175651)
- Testing
- Genetic risk assessment
- Volunteers
- 10,000 people
- Sponsor
- Scripps Translational Science Institute
Primary Open-Angle Glaucoma (POAG)
MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)
Hypothesis: The use of neurocytoprotectors helps restore the functional activity of mitochondria, improve the nervous activity of the retina and optic nerve, and stabilize the glaucomatous process.
- Trial name
- NCT06437639
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Pharmasoft
Glaucoma
Improve Glaucoma Medication Adherence
The proposed study is a randomized controlled trial enrolling Veterans with medically treated glaucoma who report less than 100% adherence to the prescribed glaucoma therapy.
- Trial name
- MAGIC (NCT03052257)
- Testing
- Educational - glaucoma, Dose monitoring and reminder, Educational - general
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Glaucoma
XEN Glaucoma Implant for the Management of Operated Uncontrolled Glaucoma: Results and Complications During a Long-Term Follow-Up
XEN Glaucoma Implant for the Management of Operated Uncontrolled Glaucoma: Results and Complications During a Long-Term Follow-Up
- Trial name
- NCT07350200
- Testing
- XEN implantation
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Military Institute od Medicine National Research Institute
Primary Open-Angle Glaucoma, Ocular Hypertension
Dose-Ranging Study of the Bimatoprost Ocular Insert
The Bimatoprost Ocular Insert is intended to provide sustained delivery of bimatoprost to the ocular surface to lower the intraocular pressure (IOP) in patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT02358369
- Testing
- Bimatoprost, Timolol 0.5%
- Where
- 10 sites in United States
- Volunteers
- 156 people
- Sponsor
- ForSight Vision5, Inc.
Glaucoma Eye, Cataract
Bulbicam Validation on Glaucoma- and Cataract Patients
The aim is to investigate repeatability and stability of the six OTH-related Bulbicam tests in patients suffering from Glaucoma (GLA), b) Cataract (CAT) and matched healthy controls (HC).
- Trial name
- NCT05449041
- Testing
- Bulbicam
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Meddoc
Glaucoma
Pilocarpine Use After Kahook Goniotomy
The goal of this study is to determine whether using pilocarpine provides added benefit to the success of combined cataract + Kahook Dual Blade (KDB) surgery.
- Trial name
- PAACK (NCT03933631)
- Testing
- Pilocarpine, Prednisolone, Ofloxacin
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Montefiore Medical Center
Glaucoma
Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT).
- Trial name
- NCT01209975
- Testing
- Selective Laser Trabeculoplasty
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Toronto
Glaucoma, Ocular Hypertension
Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells
a randomized, investigator-blind, interventinal study will compare the effect of benzalkonium-chloride (BAK) preserved and preservative-free (PF) eye drops on conjunctival goblet cells.
- Trial name
- NCT04957329
- Testing
- Xalatan, Monoprost
- Where
- 2 sites in Denmark
- Volunteers
- 28 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Glaucoma, Homocysteinemia
Effect of Vitamin Supplementation in Glaucoma Patients
The impact of targeted vitamin supplementation on retinal venous pressure (RVP) and steady state pattern ERG (SSpERG) in patients with RVP 15mmHg or more above intra-ocular pressure (IOP) and serum homocystein 12µmol/l or more…
- Conditions
- Glaucoma, Homocysteinemia, Elevated Retinal Venous Pressure, Abnormal Steady State Pattern Electroretinography
- Trial name
- NCT05080153
- Testing
- Ocufolin forte
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Devogelaere Vision
Primary Open-Angle Glaucoma (POAG), Ocular Hypertension (OHT)
Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma
Phase III trial involving topical application, in both eyes, of trabodenoson ophthalmic formulation 3.0% or 6.0% once per day or 4.5% twice per day, placebo twice per day, or timolol 0.5% twice per day for 12 weeks in adult…
- Trial name
- MATrX-1 (NCT02565173)
- Testing
- trabodenoson 4.5% BID, trabodenoson 6.0% QD, trabodenoson 3.0% QD
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Inotek Pharmaceuticals Corporation
Glaucoma
A Clinical Study Comparing the Inflammatory Response of the Ex-Press Mini Shunt to Trabeculectomy
The less invasive nature of the Ex-Press Mini shunt with mitomycin C induces less post-operative inflammation than trabeculectomy with mitomycin c.
- Trial name
- Optonol (NCT00597181)
- Testing
- Trabeculectomy with mitomycin c, Ex-Press mini shunt with mitomycin c
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Obstructive Sleep Apnoea, Primary Open-angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 2
Some people with Primary Open-angle Glaucoma (POAG) also suffer from Obstructive Sleep Apnoea (OSA), a common sleep disorder which is known to affect heart and blood vessels, and may contribute to glaucoma progression.
- Trial name
- PAIR2 (NCT03145129)
- Testing
- Continuous Positive Airway Pressure
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Glaucoma, Primary Open Angle Glaucoma
Ahmed Glaucoma Valve Surgery With Mitomycin-C
This study will determine the effectiveness of Mitomycin-C use in the glaucoma surgery Ahmed valve implantation. Approximately 100 patients will be enrolled, with half receiving the Mitomycin-C treatment and the other half…
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Secondary Glaucoma, Neovascular Glaucoma
- Trial name
- AMCT (NCT02805257)
- Testing
- Mitomycin-C, Balanced Salt Solution, Ahmed Glaucoma Valve Implant
- Where
- 4 sites in United States, China and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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