Clinical trials: Glaucoma Diagnosis
Cataract, Glaucoma
The Effects of a Large Language Model on Clinical Questioning Skills
The researchers have used the ophthalmology textbook, clinical guideline consensus, the Internet conversation data and knowledge base of Zhongshan Ophthalmology Center in the early stage, combined with artificial feedback…
- Conditions
- Cataract, Glaucoma, Diabetic Retinopathy, Keratitis
- Trial name
- NCT06229379
- Testing
- "Digital twin patient", Interaction with real patients
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Glaucoma, Angle-Closure
Implantation of Capsular Tension Ring in Primary Angle Closure Patients With Zonular Laxity or Dialysis
Primary angle closure glaucoma (PACG) is the main type of glaucoma in China, which includes acute and chronic PACG. According to the International Society of Geographical and Epidemiological Ophthalmology (ISGEO), this spectrum…
- Trial name
- NCT05542290
- Testing
- Capsular tension ring implantation, No capsular tension ring implantation
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tongren Hospital
Open-Angle Glaucoma, Ocular Hypertension
Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2%
The purpose of this study was to evaluate the efficacy and safety of a fixed combination of Brinzolamide/Brimonidine in lowering intraocular pressure (IOP) relative to each of its individual active components in patients with…
- Trial name
- NCT01297517
- Testing
- Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension, Brinzolamide ophthalmic suspension, 1%, Brimonidine tartrate ophthalmic solution, 0.2%
- Volunteers
- 1,001 people
- Sponsor
- Alcon Research
Glaucoma
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique.
- Trial name
- NCT06993597
- Testing
- Prostaglandin Analogue -Containing IOP-Lowering Therapy, Beta Blocker, Brillouin Microscopy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Narrow-Angle Glaucoma
Combined VCST With Phacoemulsification Versus Phacoemulsification in Primary Angle Closure Glaucoma
As ab externo metal probe trabeculotomy cannot achieve 360-degree circumferential angle surgery, prolene suture can be used to achieve this without the need for an illuminated microcatheter.
- Trial name
- NCT06120621
- Testing
- Arm 1 : VCST-phaco group , Arm 2 : phaco group.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Glaucoma, Ocular Hypertension
Safety and Efficacy Study of Bimatoprost in Ethnically Japanese Patients With Open-Angle Glaucoma or Ocular Hypertension
This study evaluates the safety and efficacy of once-daily bimatoprost 0.03% and 0.01% ophthalmic solutions compared with once-daily administered bimatoprost vehicle ophthalmic solution for 2 weeks in ethnically Japanese patients…
- Trial name
- NCT00651859
- Testing
- Bimatoprost 0.01% Ophthalmic Solution, Bimatoprost 0.03% Ophthalmic Solution, Bimatoprost Vehicle Ophthalmic Solution
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Allergan
Glaucoma, Suspect
CLAD Deconvolved PERG Responses in Glaucoma Patients
Glaucoma is a progressive disease resulting in blindness. Determining the onset of the disease is critical so patients may obtain treatment to preserve useful vision.
- Trial name
- NCT06388096
- Testing
- Pattern Electroretinogram
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jorvec Corp.
Glaucoma, Open-Angle, Glaucoma, Narrow Angle
Study of a Cilioscleral Interposition Device (CID) SV22 in Patients With Primary Open Angle Glaucoma and Narrow Angle Glaucoma
The purpose of this study is to evaluate the safety and effectiveness of implanting a new version of an interposition supraciliary implant (SV22) as a stand-alone therapy for lowering intraocular pressure (IOP) in patients with…
- Trial name
- SAFARI 3 (NCT05236439)
- Testing
- Interposition supraciliary implant
- Where
- Armenia
- Volunteers
- 57 people
- Sponsor
- Ciliatech
Glaucoma
Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma
To determine the area under the Receiver Operator Characteristic Curve (AUC) for the Ganglion Cell Analysis (GCA) average thickness.
- Trial name
- NCT01272102
- Where
- 4 sites in United States
- Volunteers
- 119 people
- Sponsor
- Carl Zeiss Meditec, Inc.
Primary Open Angle Glaucoma
IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy With Collagen Implant
Primary open angle glaucoma (POAG) is associated with inadequate drainage of the aqueous humor via the trabecular meshwork towards the systemic circulation. This may lead to an increase in IOP and may damage the optic nerve.
- Trial name
- NCT01561001
- Testing
- SENSIMED Triggerfish®
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Sensimed AG
Primary Open-angle Glaucoma, Cataract
MINIject Implantation Combined With Cataract Surgery in Patients With POAG and Cataract
The study will assess safety and performance of MINIject implant in patients with open-angle glaucoma uncontrolled by topical hypotensive medications in conjunction with cataract surgery.
- Trial name
- STAR-VI (NCT05432245)
- Testing
- Phacoemulsification combined with minimally invasive glaucoma surgery (MIGS)
- Where
- 4 sites in Panama, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- iSTAR Medical
Ocular Surface Disease, Glaucoma
Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure
Evaluation of the safety and efficacy of hydrocortisone eye drops in the treatment of OSD (ocular surface disease) patients with and without glaucoma.
- Trial name
- NCT04536129
- Testing
- Hydrocortisone (CORTIVIS ®)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Molise
Iris Diseases
Electron Microscopic Examination of Iris Tissue in Buphthalmos
To revise the etiology of the primary congenital glaucoma in some infants.
- Trial name
- NCT07034651
- Testing
- Combined trabeculotomy trabeculectomy with mitomycin C
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Angle-closure Glaucoma
Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)
The purpose of this study is to demonstrate that the Intraocular Pressure (IOP) lowering efficacy of Travoprost Ophthalmic Solution 0.004% is superior to that of Pilocarpine 1% in patients with chronic angle-closure glaucoma…
- Trial name
- NCT00762645
- Testing
- Travoprost 0.004% (Travatan), Pilocarpine 1%
- Volunteers
- 30 people
- Sponsor
- Alcon Research
Glaucoma, Open Angle
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma
Low-pressure (normal tension) glaucoma is a type of open-angle glaucoma resulting in damage to the optic nerve and abnormalities of the visual field.
- Trial name
- NCT00317577
- Testing
- brimonidine, timolol
- Where
- 12 sites in United States
- Volunteers
- 160 people
- Sponsor
- Chicago Center for Vision Research
Glaucoma, Neovascular
Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied
The researchers in this trial want to learn how the drug aflibercept works in in Japanese patients with increased eye pressure that is caused by new blood vessels growing in the eye (neovascular glaucoma or NVG).
- Trial name
- VENERA (NCT03639675)
- Testing
- Aflibercept (EYLEA, BAY86-5321), Topical IOP-lowering drugs
- Where
- 7 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Bayer
Open-angle Glaucoma, Ocular Hypertension
A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension
The purpose of this study is to assess patient compliance with DuoTrav versus concomitant administration of Timolol 0.5% plus TRAVATAN in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00465803
- Testing
- Travoprost 0.004%/timolol 0.5% ophthalmic solution, Travoprost ophthalmic solution, 0.004%, Timolol maleate ophthalmic solution, 0.5%
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma
Memantine in Patients With Chronic Glaucoma
Randomized double-masked clinical trial of memantine in patients with glaucoma
- Trial name
- NCT00168350
- Testing
- memantine
- Volunteers
- 1,179 people
- Sponsor
- Allergan
Open Angle Glaucoma
A First in Human Clinical Trial to Evaluate the Safety and Effectiveness of the STREAMLINE SURGICAL SYSTEM in Patients With Open-Angle Glaucoma
A prospective, nonrandomized, open label study to evaluate the safety and IOP lowering effectiveness of the Streamline Surgical System, in patients with mild-to-moderate open angle glaucoma undergoing cataract surgery.
- Trial name
- NCT05089474
- Testing
- Streamline Surgical System
- Where
- 3 sites in Costa Rica, Dominican Republic and 1 more
- Volunteers
- 45 people
- Sponsor
- New World Medical, Inc.
Pseudoexfoliation Syndrome, Glaucoma
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma
Glaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head.
- Trial name
- NCT00327613
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
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