Clinical trials: Glaucoma Diagnosis
Glaucoma
Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide
Impaired ocular blood flow is an important risk factor in the pathogenesis of primary open angle glaucoma (POAG). A few studies suggest that topical dorzolamide 2% may increase optic nerve perfusion.
- Trial name
- NCT00152932
- Testing
- Dorzolamide 2% drops, HRF and CLBF
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Refractory Glaucoma
CPC in Adult Refractory Glaucoma
The purpose of this study is to assess the relative effectiveness and safety of diode laser cyclophotocoagulation procedure to reduce IOP and relieve pain in adult patients with refractory glaucoma.
- Trial name
- NCT04921098
- Testing
- Diode Laser Cyclophotocoagulation
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sohag University
Glaucoma, Open-Angle
Silicone Tube for the Surgical Treatment of Glaucoma
The biocompatible silicone tube miniature drainage device is a small, non-valved implant to shunt aqueous humor underneath the conjunctiva to control the intraocular pressure.
- Trial name
- NCT03558126
- Testing
- silicone tube
- Volunteers
- 36 people
- Sponsor
- yin ying zhao
Glaucoma
SENSIMED Triggerfish Safety and Tolerability
The purpose of this investigation is to study the safety and tolerability of SENSIMED Triggerfish, a soft contact lens-based device intended to continuously record relative changes in intraocular pressure (IOP).
- Trial name
- NCT01319617
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sensimed AG
Congenital Glaucoma
Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France
Evidence of a relationship between age at discovery of congenital glaucoma and visual acuity at 4 years of age. The delay in diagnosis is a factor of poor visual acuity.
- Trial name
- Conglau (NCT03077789)
- Testing
- TRABECULOTOMY
- Where
- 24 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Lille
Primary Open Angle Glaucoma, Acupressure
Regulation of Intraocular Pressure in Glaucoma Patients by Acupressure
The purpose of this clinical trial is to implement acupressure twice daily and monitor the changes in intraocular pressure (IOP) in patients with different levels of glaucoma.
- Trial name
- NCT05898997
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Glaucoma, Suspect
CLAD Deconvolved PERG Responses in Glaucoma Patients
Glaucoma is a progressive disease resulting in blindness. Determining the onset of the disease is critical so patients may obtain treatment to preserve useful vision.
- Trial name
- NCT06388096
- Testing
- Pattern Electroretinogram
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jorvec Corp.
Glaucoma, OHT - Ocular Hypertension
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments.
- Trial name
- NCT04412096
- Testing
- Timolol 0.5% ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Ohio State University
Glaucoma
The Laser in Pseudoexfoliation (LIP) Study
A number of large clinical trials have found pseudoexfoliation (PXF) to be a major risk factor for glaucoma progression and risk of blindness.
- Trial name
- LIP (NCT01704989)
- Testing
- SLT Laser, Prostagladin
- Where
- Canada
- Sponsor
- Nova Scotia Health Authority
Ocular Hypertension
Safety and Efficacy of Liposomal Latanoprost in Ocular Hypertension
Aim: Evaluation of a single subconjunctival injection of liposomal EggPC formulation of latanoprost in treating glaucoma. Hypothesis: The investigators have already evaluated carrier stability, drug partitioning, in vitro drug…
- Trial name
- NCT01987323
- Testing
- Subconjunctival injection of liposomal latanoprost
- Volunteers
- 6 people
- Sponsor
- Singapore Eye Research Institute
Glaucoma, Intraocular Pressure
Screening for Glaucoma in Namil Area, South Korea
The purpose of this study is to study the prevalence of glaucoma in Korea, the investigators selected Namil area in Geumsan city, located in central Korea.
- Conditions
- Glaucoma, Intraocular Pressure, Optic Nerve Head, Visual Field
- Trial name
- NCT00727168
- Where
- South Korea
- Volunteers
- 1,532 people, healthy volunteers welcome
- Sponsor
- Korean Glaucoma Society
Glaucoma, Open-Angle
Preservative-free Tafluprost/Timolol Fixed Combination: Morning vs Evening Dosing
The ideal dosing for preservative-free tafluprost/timolol fixed combination remains to be elucidated. The present study compared the 24-hour intraocular pressure efficacy obtained with tafluprost/timolol given once in the evening…
- Trial name
- TTFC (NCT03612817)
- Testing
- Tafluprost/timolol fixed combination
- Where
- Greece
- Volunteers
- 42 people
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma, Suspect, Diabetic Retinopathy
Eye Health Intervention Study in Upper Manhattan
Individuals living in Upper Manhattan have limited access to eye care, high vision impairment rates, and poor ocular health outcomes.
- Conditions
- Glaucoma, Suspect, Diabetic Retinopathy, Cataract, Refractive Errors
- Trial name
- EYES-UM (NCT06112431)
- Testing
- Intervention, Usual Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye
Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
To explore an effective diagnostic tool of glaucoma through the dynamic analysis of computerized pupillary light reflex assessment device (CPLRAD) pupillography based on iris recognition techniques and investigate its feasibility…
- Conditions
- Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye, Primary Open Angle Glaucoma of Both Eyes, Suspect Glaucoma
- Trial name
- NCT04595227
- Testing
- Computerized pupillary light reflex assessment device
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Primary Open Angle Glaucoma, Ocular Hypertension
Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
Reduction of elevated pressure in the eye (Intraocular pressure, or 'IOP') with eye drop medications has been shown to be effective in delaying or preventing the progression of glaucoma, and it is the only proven method for…
- Trial name
- ANGEL-2 (NCT04742283)
- Testing
- DE-126 Ophthalmic Solution 0.002% QD, Timolol Maleate Ophthalmic Solution 0.5% BID
- Where
- 41 sites in United States
- Volunteers
- 323 people
- Sponsor
- Santen Inc.
Primary Open Angle Glaucoma
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT04396002
- Testing
- Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Glaucoma
TRK-3 Conformance to Standards for Tonometers
To collect measurements of a new tonometer and show conformance to standards for tonometers.
- Trial name
- NCT06247072
- Testing
- Tonometer
- Where
- 2 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Topcon Corporation
Open Angle Glaucoma (OAG) Surgeries, Deep Sclerectomy
Deep Sclerectomy With Scleral Bed Fenestration Versus Trabeculectomy in Medically Uncontrolled Primary Open Angle Glaucoma Patients
this study tries to find the efficacy of adding certain modifications to deep sclerectomy in primary open angle glaucoma patients who can no be controlled by medical therapy and if it can reach trabeculectomy efficacy or not
- Conditions
- Open Angle Glaucoma (OAG) Surgeries, Deep Sclerectomy, Open Angle Glaucoma (OAG)
- Trial name
- NCT07800637
- Testing
- deep sclerectomy with scleral bed fenestration, Trabeculectomy
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Minia University
Open Angle Glaucoma or Ocular Hypertension
A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study
The purposes of this study are to evaluate the long-term safety and intraocular pressure-lowering efficacy of DE-117 ophthalmic solution monotherapy and concomitant use of DE-117 ophthalmic solution with timolol ophthalmic…
- Trial name
- NCT02822729
- Testing
- DE-117 ophthalmic solution, Timolol ophthalmic solution
- Where
- Japan
- Volunteers
- 125 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Open Angle Glaucoma
Study of OMNI System in OAG (GEMINI)
This study will prospectively assess the clinical effect of ab-interno transluminal viscoelastic delivery and trabeculotomy performed using the OMNI Surgical System in combination with Cataract Extraction on intraocular pressure…
- Trial name
- NCT03861169
- Testing
- Transluminal viscoelastic delivery and trabeculotomy
- Where
- 15 sites in United States
- Volunteers
- 209 people
- Sponsor
- Sight Sciences, Inc.
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