Clinical trials: Glaucoma Diagnosis
Glaucoma
The Effects of Changing Light Levels on Contrast Sensitivity in Patients With Glaucoma
The study is a prospective observational study where participants will be recruited from the Ophthalmology department (Outpatient department, Eye Casualty). Only one research visit will be required.
- Trial name
- ENLIGHTEN (NCT04061343)
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Glaucoma, Glaucoma Eye
Augmented Macular Pigment-containing Nutraceutical and Central Visual Function
The purpose of this study is to prospectively analyze changes in macular pigment optical density and dermal carotenoid levels as they relate to visual field function in patients prescribed a macular pigment-containing medical…
- Conditions
- Glaucoma, Glaucoma Eye, Glaucoma, Open-Angle
- Trial name
- NCT04676126
- Testing
- Lumega-Z, Dorzolamide Hcl 2% Oph Soln
- Where
- United States
- Sponsor
- University of the Incarnate Word
Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO)
High-throughput Large-model-based AI-assisted Diagnosis Using OCT
This observational study aims to establish key technologies for high-throughput, large-model-based AI-assisted diagnosis using optical coherence tomography (OCT) and OCT angiography (OCTA).
- Conditions
- Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO), Age-Related Macular Degeneration (AMD), Pathologic Myopia
- Trial name
- NCT07249307
- Testing
- No intervention
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
Ocular Hypertension, Open Angle Glaucoma
Effect of SIMBRINZA® Suspension as an Added Therapy to TRAVATAN Z®
The purpose of this study is to demonstrate the additive effect of brinzolamide 1%/brimonidine 0.2% (SIMBRINZA® suspension) in subjects with either open angle glaucoma or ocular hypertension who are currently on a prostaglandin…
- Trial name
- NCT01937299
- Testing
- Brinzolamide 1%/brimonidine 0.2% ophthalmic suspension, Vehicle, Travoprost 0.004% ophthalmic solution
- Volunteers
- 307 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma, Cataract
Additional Long-Term Follow-up for Subjects Implanted With a CyPass® Micro-Stent
The purpose of this study is to assess long-term (10 years post-CyPass implantation) status of the corneal endothelium in subjects who were implanted with the CyPass Micro-Stent in the COMPASS trial.
- Trial name
- COMPASS XXT (NCT04629521)
- Testing
- CyPass Micro-Stent, Cataract Surgery
- Where
- 12 sites in United States
- Volunteers
- 54 people
- Sponsor
- Alcon Research
Glaucoma, Eye Diseases
KJ-TFC-004 Drug-drug Interaction Study
To assess the pharmacokinetic Interaction between Dorzolamide and Brimonidine in healthy male subjects.
- Conditions
- Glaucoma, Eye Diseases, Ocular Hypertension
- Trial name
- NCT02967614
- Testing
- [A], [B], [A]+[B](1)
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kukje Pharma
Healthy
The Pharmacokinetics of D565 and the Drug Effect of D565 on Pharmacokinetic Characteristics of D930
This study is a single sequence, 3-period, multiple-dose study to evaluate the pharmacokinetics of D565 and the drug effect of D565 on pharmacokinetic characteristics of D930 in healthy male volunteers.
- Trial name
- NCT03034486
- Testing
- D930, D565
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Glaucoma
Observational Study of How Patients Take Eye Drops
This study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation…
- Trial name
- NCT00750646
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Primary Open Angle Glaucoma
Rocklatan Adds Pressure Reduction After MIGS (Minimally Invasive Glaucoma Surgery)
The primary objective of this study is to determine if the addition of Rocklatan post-Hydrus will provide additional intraocular pressure lowering.
- Trial name
- NCT07048886
- Testing
- Rocklatan (netarsudil 0.02% and latanoprost 0.005%), Systane
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Center for Sight Las Vegas
Glaucoma, Ocular Hypertension
A Study to Evaluate Pharmacokinetics of Tafluprost Ophthalmic Solution (0.0015%) in Pediatric Patients With Glaucoma or Ocular Hypertension
The purpose of the study is to examine how preservative free tafluprost ophthalmic solution (0.0015%) is distributed in blood circulation after ocular administration in children who have glaucoma or elevated intraocular pressure.
- Trial name
- NCT02102750
- Testing
- Preservative free tafluprost opthalmic solution
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 17 people
- Sponsor
- Santen Oy
Primary Open Angle Glaucoma
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT04396002
- Testing
- Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Glaucoma Open-Angle
Feasibility, Accuracy, and Reproducibility of Virtual Reality Visual Field Testing in Patients With Glaucoma
The goal of this clinical trial is to evaluate the feasibility of using virtual reality based visual field testing to monitor glaucoma in a clinical setting.
- Trial name
- NCT07063537
- Testing
- Virtual Reality Visual Field (VR-VF)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Nova Scotia Health Authority
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Glaucoma
Effect of an Anterior Chamber Infusion System on Trabeculectomy Outcomes
In the treatment of glaucoma, trabeculectomy surgery provides a drainage system for the eye and allows for the lowering of the pressure inside the eye.
- Trial name
- NCT00551902
- Testing
- Trabeculectomy with anterior chamber infusion system, Trabeculectomy without anterior chamber infusion system
- Where
- 2 sites in Canada
- Sponsor
- Queen's University
Glaucoma, Glaucoma, Open-Angle
Glaucoma Surgery Using the ViaLase Laser System
Prospective, single-center, multi-cohort clinical trial of ViaLase Laser for the reduction of IOP in patients with open angle glaucoma.
- Trial name
- NCT04949802
- Testing
- ViaLase Laser
- Where
- Hungary
- Volunteers
- 22 people
- Sponsor
- Vialase, Inc.
Glaucoma
Will Restasis Eye Drops Increase Your Chance of Having a Successful Surgery?
The purpose of this study is to determine whether reducing inflammation of the surface of the eye with topical Restasis after glaucoma surgery will improve surgical outcomes and increase patient comfort.
- Trial name
- NCT00405431
- Testing
- Restasis, Endura (artificial tears)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Wills Eye
Open Angle Glaucoma, Ocular Hypertension
Diurnal and Nocturnal Effect of Travatan With SofZia Preservative on Intraocular Pressure and Ocular Perfusion Pressure
The purpose of this research study is to determine the diurnal and nocturnal effects of Travoprost with SofZia (Travatan Z) on intraocular pressure and ocular perfusion pressure.
- Trial name
- NCT01779778
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Primary Open Angle Glaucoma, Glaucoma, Open Angle, Pseudo-exfoliative
Safety and Efficacy Trial to Evaluate the Hydrus(TM) Implant in Subjects Undergoing Cataract Surgery.
The objective of this study is to demonstrate the ability of the Hydrus Implant to lower intraocular pressure in glaucoma patients undergoing cataract surgery.
- Conditions
- Primary Open Angle Glaucoma, Glaucoma, Open Angle, Pseudo-exfoliative, Cataract Unilateral Pending Extraction
- Trial name
- Hydrus II (NCT01818115)
- Testing
- Hydrus Implant, IOL placement
- Where
- 7 sites in Germany, Italy and 2 more
- Volunteers
- 100 people
- Sponsor
- Ivantis, Inc.
Glaucoma, Congenital Glaucoma
Kahook Dual Blade Ab-interno Trabeculotomy Versus ab Externo Viscotrabeculotomy in Primary Congenital Glaucoma
This prospective study aims to compare KDB ab-interno trabeculotomy to ab externo rigid probe viscotrabeculotomy in patients with PCG.
- Trial name
- NCT05115708
- Testing
- ab externo viscotrabeculotomy, The Kahook dual blade® (KDB) assisted ab-interno trabeculotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Age-Related Macular Degeneration, Diabetic Retinopathy
Defining Retinal Structures Using Hyperspectral Retinal Imaging
This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease.
- Conditions
- Age-Related Macular Degeneration, Diabetic Retinopathy, Glaucoma, Retinal Diseases
- Trial name
- NCT07555574
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
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