Clinical trials: Glaucoma Secondary
Open Angle Glaucoma
Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves and Second Trabeculectomy in Glaucoma Patients
In the management of open angle glaucoma, frequently more then one procedure is necessary to control the intra ocular pressure. There is still no consensus whether this second intervention should be a second trabeculectomy or a…
- Trial name
- NCT00665756
- Testing
- second Trabeculectomy, Ahmed Implant
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Glaucoma,Open-Angle, Ocular Hypertension
Non Interventional Study in Patients With Open Angle Glaucoma and/or Ocular Hypertension Treated With XALATAN®
The primary objective is to evaluate the Intraocular pressure reducing effect of Xalatan over 3 months. The secondary objective is to study the other efficacy parameters during treatment for 3 months
- Trial name
- NCT00486252
- Testing
- Observational
- Volunteers
- 996 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Open Angle Glaucoma
Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
This study objective is to evaluate the intraocular pressure (IOP) lowering effect of two trabecular micro-bypass stents (iStent inject) in eyes of subjects with primary open-angle glaucoma on one topical hypotensive medication
- Trial name
- NCT02868190
- Testing
- Two trabecular micro-bypass stents (iStent inject)
- Where
- Armenia
- Volunteers
- 57 people
- Sponsor
- Glaukos Corporation
Glaucoma, Angle-Closure, Glaucoma Suspect
Effects of Systemic Drugs on Intraocular Pressure
To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.
- Conditions
- Glaucoma, Angle-Closure, Glaucoma Suspect, Glaucoma Secondary to Drugs, Bilateral, Hypertension
- Trial name
- NCT05328921
- Testing
- Antihypertensive Agents, Antihistaminics
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Glaucoma, Ocular Hypertension
Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP
Glaucoma is the most frequent cause of irreversible \& preventable blindness worldwide, affecting about 2% of the world's population in people over 40.
- Conditions
- Glaucoma, Ocular Hypertension, IOP
- Trial name
- EXP-LP (NCT03318146)
- Testing
- drug delivery system, XALATAN®
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Glaucoma Secondary
Treatment of Malignant Glaucoma by Anterior Vitrectomy From Two Different Approaches
To compare the surgical outcomes of treating phacoemulsification with intraocular lens implantation combined with goniosynechialysis (Phaco-IOL-GSL) associated malignant glaucoma (MG), using different incision sites in anterior…
- Trial name
- NCT04172857
- Testing
- anterior vitrectomy combined with hyaloidotomy, zonulectomy and iridectomy
- Volunteers
- 9 people
- Sponsor
- Wenzhou Medical University
Lens Implantation, Intraocular
Incidence of Glaucoma-related Adverse Events in Pediatric Secondary Intraocular Lens Implantation
To compare the incidence of glaucoma-related adverse events of in-the-bag versus ciliary-sulcus-fixed secondary intraocular lens (IOL) implantation in pediatric aphakia
- Trial name
- NCT05136950
- Testing
- Secondary in-the-bag IOL fixation, Secondary ciliary sulcus IOL fixation
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma Secondary, Congenital Cataract
Quantitatively Analysis of Fundus Structure Characteristics in Glaucoma Following Congenital Cataract Surgery
To quantitatively analyze the fundus structure and microvascular characteristics of GFCS and non-GFCS (NGFCS) using optical coherence tomography angiography (OCTA), to explore the vascular-structural association, and to assess…
- Trial name
- NCT05446077
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Sun Yat-sen University
Glaucoma, Open-Angle, Glaucoma Secondary
The Outcome of Ahmed Glaucoma Valve in Difficult Glaucoma Cases
The clinical difference (mean IOP, success rate, and complications) on using S2 and FP7 models of Ahmed Glaucoma Valve that had similar dimensions and different materials used for their construction in one year follow up was…
- Conditions
- Glaucoma, Open-Angle, Glaucoma Secondary, Glaucoma, Neovascular
- Trial name
- NCT04214847
- Testing
- Ahmed Glaucoma Valve surgery
- Volunteers
- 1 people
- Sponsor
- Ain Shams University
Glaucoma
Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
- Trial name
- NCT07495852
- Testing
- Gen 2 Travoprost Intracameral Implant, Timolol eye drops 0.5%
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle, Glaucoma, Angle-Closure
Keratometric Change After XEN, Trabeculectomy and Tube Shunts
The main goal of this study is to assess the severity of postoperative corneal astigmatism induced by implantation of the XEN Gel Stent compared to that induced by traditional filtering surgery (trabeculectomy and GDDs).
- Conditions
- Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma Secondary, Glaucoma Eye
- Trial name
- Topo-XEN (NCT04602923)
- Testing
- Corneal topography: OPD-Scan, Corneal topography: Pentacam
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Uveitis, Glaucoma
Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema
Assessment of optic disc morphology can be difficult in patients with uveitis and papilloedema. Therefore different optical coherence tomography (OCT) and laser scanning techniques may help to detect damage to the retinal nerve…
- Trial name
- NCT01170481
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- St. Franziskus Hospital
Glaucoma
Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
- Trial name
- NCT07075718
- Testing
- Gen 2 Travoprost Intracameral Implant, Timolol eye drops 0.5%
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- Glaukos Corporation
Glaucoma
AGV Implantation With Ologen in Pediatric Glaucomas
Ahmed Glaucoma Valve Implantation with Ologen augmentation in secondary pediatric glaucomas: A 2-year randomized controlled trial. Background: Many studies have investigated the clinical benefits of Ologen for trabeculectomy.
- Trial name
- NCT05014386
- Testing
- Ahmed Glaucoma Valve Implantation in secondary pediatric glaucomas., Ahmed Glaucoma Valve Implantation with Ologen augmentation in secondary pediatric glaucomas
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma Due to PEX
Contrast Sensitivity in Glaucoma
The primary aim of the Erlangen´s Glaucoma Contrast Sensitivity-Study (EGCS-Study) is the evaluation of the diagnostic and prognostic validity of a diagnostic procedure, measuring contrast sensitivity.
- Trial name
- NCT00947869
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Coronary Artery Disease, Glaucoma
Prospective Electronic Polygenic Risk Study - Second Phase
This study will investigate the role of polygenic risk scores (PRS) in preventive health.
- Trial name
- PEPRS2 (NCT05175651)
- Testing
- Genetic risk assessment
- Volunteers
- 10,000 people
- Sponsor
- Scripps Translational Science Institute
Glaucoma
The American Glaucoma Society (AGS) Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study (ASSISTS)
Outcomes of subjects with uncontrolled glaucoma with a single existing aqueous tube shunt implant undergoing a second aqueous shunt to transscleral diode laser cyclophotocoagulation.
- Trial name
- ASSISTS (NCT02691455)
- Testing
- Baerveldt Glaucoma Implant 350-mm2 / BG101-350, Transscleral Diode Laser Cyclophotocoagulation, Ahmed Model FP7 Flexible Plate
- Where
- 23 sites in United States
- Volunteers
- 50 people
- Sponsor
- Robert Feldman