Clinical trials: Glaucoma Therapy
Glaucoma, Pulmonary Hypertension
Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy
There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve.
- Trial name
- NCT00452283
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Neovascular Glaucoma
Avastin as an Adjunct to Diode Laser in the Treatment of Neovascular Glaucoma
Assess the efficacy of Avastin as an adjunct to Diode Laser cyclophotocoagulation in the treatment of Neovascular Glaucoma.
- Trial name
- NCT01051583
- Testing
- Diode laser cyclophotocoagulation enhanced by intravitreal injection of Avastin
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Cairo University
Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral
Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG)
Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in normal tension glaucoma patients.
- Conditions
- Normal Tension Glaucoma (NTG), Low-Tension Glaucoma, Bilateral, Low-Tension Glaucoma, Unspecified Eye, Glaucoma
- Trial name
- Nightingale (NCT06030193)
- Testing
- QLS-111 ophthalmic solution (0.015%), Timolol Maleate PF 0.5% Ophthalmic Solution (Timolol)
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Qlaris Bio, Inc.
Primary Open-angle Glaucoma
Educational Intervention to Adopt SLT as First-Line Glaucoma Treatment
The purpose of this study is to develop an educational program that will help improve the patients' understanding of what laser treatment is, how it might be beneficial to them, and why it should be the first eye pressure…
- Trial name
- NCT03365778
- Testing
- Patient Educational Intervention, Usual Care, Ophthalmologist Educational Intervention
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Wills Eye
Glaucoma
Community Based Treatment for (ComBaT) Glaucoma
The purpose of this research is to evaluate if intervention and education can change the behavior of someone's willingness to see an eye care provider to prevent blindness and glaucoma.
- Trial name
- NCT06124521
- Testing
- ComBaT Glaucoma
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Glaucoma, Open-Angle, Ocular Hypertension
To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes
To compare the safety and efficacy of Perrigo's product to an FDA approved product in the treatment of Primary Open Angle Glaucoma or Ocular Hypertension in Both Eyes.
- Trial name
- NCT04024072
- Testing
- Brinzolamide 1% ophthalmic suspension, Azopt 1% Ophthalmic Suspension
- Where
- United States
- Volunteers
- 495 people
- Sponsor
- Padagis LLC
Glaucoma, Open-Angle, Glaucoma
Exercise Intervention in Primary Open-angle Glaucoma
EYE-FIT is a randomized clinical trial with a two-arm parallel design aimed at assessing the impact of performing a structured and supervised physical training program on the different variables associated with glaucoma…
- Trial name
- EYE-FIT (NCT05704777)
- Testing
- Exercise, Control
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- Universidad de Granada
Glaucoma, Glaucoma Suspect
Eyedrop Instillation Technique
Eye drop instillation is a problem from glaucoma patients. Studies reveal that 30-50% of glaucoma patients have problems instilling their eyedrops.
- Trial name
- NCT01417689
- Testing
- Encouragement to attempt eye drop instillation with a specific technique
- Where
- Chile
- Volunteers
- 230 people
- Sponsor
- Oftalmologia Hospital Sotero del Rio
Ocular Hypertension, Open Angle Glaucoma
Effect of SIMBRINZA® Suspension as an Added Therapy to a Prostaglandin Analogue
The purpose of this study is to demonstrate the additive effect of brinzolamide 1%/brimonidine 0.2% (SIMBRINZA® suspension) in subjects with either open angle glaucoma or ocular hypertension who are currently on a prostaglandin…
- Trial name
- NCT01937312
- Testing
- Brinzolamide 1%/brimonidine 0.2% ophthalmic suspension, Vehicle, Prostaglandin analogue
- Volunteers
- 282 people
- Sponsor
- Alcon Research
Primary Open-angle Glaucoma, Ocular Hypertension
Switching From the Preserved to the Preservative - Free Latanoprost - Timolol FC in Glaucoma Patients With OSD
Glaucoma is a group of chronic eye diseases that are characterized by a progressive optic nerve damage and consequent visual loss. In most cases, it is associated with elevated intraocular pressure.
- Trial name
- NCT04891588
- Testing
- Switching the preserved prostaglandin analog-timolol FC to Fixalpost (preservative free prostaglandin analog-timolol FC)
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Glaucoma, Glaucoma, Open-Angle
Impact of Self-tonometry on Glaucoma Treatment Decision.
Self-tonometry with iCare Home is performed by one hundred patients annually at Sankt Erik's Eye Hospital. The investigators want to evaluate the impact that self-tonometry results have on the clinician's choice of glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, OHT - Ocular Hypertension, Glaucoma Capsulare
- Trial name
- NCT04888156
- Testing
- Unchanged treatment, Changed treatment
- Where
- Sweden
- Volunteers
- 133 people
- Sponsor
- St. Erik Eye Hospital
Glaucoma
Antisecretory Factor (AF) Effects on Intraocular-pressure
Glaucoma is a complex and chronic eye disease which damages the optic nerve. One of the main risk factors for the progression of glaucoma is IOP.
- Trial name
- NCT02731118
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- St. Erik Eye Hospital
Glaucoma, Ocular Hypertension
Efficacy of Selective Laser Trabeculoplasty in Patients Under Treatment With Topical Prostaglandines
Retrospective analysis of efficacy of selective laser trabeculoplasty in patients under treatment with topical prostaglandins compared to patients without topical prostaglandins is performed.
- Trial name
- NCT01467440
- Testing
- Selective Laser Trabeculoplasty
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Angle Closure Glaucoma
Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure
This is a randomised controlled clinical trial to compare laser peripheral iridotomy (LPI) and primary phacoemulsification with intra-ocular lens implantation (phaco/IOL) in the treatment of acute primary angle-closure glaucoma…
- Trial name
- NCT00350428
- Testing
- Laser Preipheral Iridotomy and phacoemulsification
- Where
- Singapore
- Volunteers
- 70 people
- Sponsor
- Singapore National Eye Centre
Glaucoma, Electrical Stimulation
Treatment of Patients With Optic Nerve Damage Patients Using Electrostimulation
The aim of the present study is to investigate the possibilities of visual field enhancement with electrical stimulation (ES) as a home stimulation method, in a total of 50 patients with optical neuropathy, who have already been…
- Conditions
- Glaucoma, Electrical Stimulation, Home Treatment
- Trial name
- HomeStim (NCT04010994)
- Testing
- Transorbital electrical stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Magdeburg
Angle Closure Glaucoma, Glaucoma
Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies
Purpose: To evaluate short-term angle opening after argon peripheral iridoplasty using AS-OCT and to report its complications at 1-week and 1-month follow up in patients that did not achieve a satisfactory clinical angle opening…
- Trial name
- ALPIECA (NCT02199158)
- Testing
- Argon Laser Peripheral Iridoplasty
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Primary Congenital Glaucoma, Pediatric Glaucoma
Subscleral Trabeculectomy With Inverted T-Shaped Deep Sclerectomy for Primary Congenital Glaucoma
Primary congenital glaucoma (PCG) is a vision-threatening disorder of childhood characterized by elevated intraocular pressure (IOP) resulting from developmental abnormalities of the anterior chamber angle.
- Conditions
- Primary Congenital Glaucoma, Pediatric Glaucoma, Intraocular Pressure
- Trial name
- TDS-PCG (NCT07701278)
- Testing
- Subscleral Trabeculectomy Combined With Inverted T-Shaped Deep Sclerectomy
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Benha University
Primary Open Angle Glaucoma
EXTERNAL SLT Treatment in Patients With Uncontrolled OPEN ANGLE GLAUCOMA
The purpose of this study is to evaluate the advantages and disadvantages of external selective laser trabeculoplasty (SLT) in treating open angle glaucoma,compared to traditional SLT.
- Trial name
- ETSG (NCT01384149)
- Testing
- external slt, standard slt
- Where
- 3 sites in Israel
- Volunteers
- 32 people
- Sponsor
- Meir Medical Center
Primary Open Angle Glaucoma or Ocular Hypertension
A Comparative Study of Intraocular Pressure Control Using Selective Laser Trabeculoplasty and Latanoprost as Initial Treatments for Primary Open Angle Glaucoma and Ocular Hypertension in Lagos State University Teaching Hospital
The goal of this clinical trial is to compare the short-term efficacy and safety of selective laser trabeculoplasty (SLT) to 0.005% latanoprost eye drops in lowering intraocular pressure (IOP) as primary therapy in…
- Trial name
- NCT07310719
- Testing
- Selective laser trabeculoplasty, Latanoprost (0.005%)
- Where
- Nigeria
- Volunteers
- 138 people
- Sponsor
- Lagos State Health Service Commission
Glaucoma, Ocular Hypertension
Continuous Intraocular Pressure (IOP) Measurement and Ability to Detect Treatment Effect
Continuous intraocular pressure (IOP) measurement with a contact lens sensor may provide more information on the drug-related IOP change than 24-hour IOP measurement with Goldmann applanation tonometry (GAT.
- Trial name
- NCT01491867
- Testing
- travoprost 0.003%
- Where
- 2 sites in Hungary
- Volunteers
- 9 people
- Sponsor
- Semmelweis University