Clinical trials: Glaucoma Therapy
Open-Angle Glaucoma, Ocular Hypertension
Efficacy of Changing to TRAVATAN® From Prior Therapy
The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® Solution without benzalkonium chloride (BAK) in patients previously on latanoprost 0.005% or bimatoprost 0.01% ophthalmic solution monotherapy.
- Trial name
- NCT01493427
- Testing
- Travoprost 0.004%
- Volunteers
- 202 people
- Sponsor
- Alcon Research
Glaucoma, Open-angle, Ocular Hypertension
A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate the intraocular pressure(IOP)-lowering efficacy of a combination IOP-lowering therapy in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00311389
- Testing
- Travoprost 0.004%/Timolol maleate 0.5% ophthalmic solution, Latanoprost 0.005%/Timolol 0.005% ophthalmic solution
- Where
- Belgium
- Volunteers
- 408 people
- Sponsor
- Alcon Research
Open-angle Glaucoma, Ocular Hypertension
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00314158
- Testing
- Brinzolamide 10 mg/ml + Timolol 5 mg/ml eye drops, suspension, Brinzolamide 10 mg/ml (AZOPT) eye drops, suspension, Timolol 5 mg/ml eye drops, solution
- Where
- United States
- Volunteers
- 523 people
- Sponsor
- Alcon Research
Cataract, Glaucoma
Potential Research Participants for Future Studies of Inherited Eye Diseases
This study will evaluate potential candidates for future clinical research studies related to diagnosed or undiagnosed genetic eye disorders or diseases.
- Conditions
- Cataract, Glaucoma, Retinitis Pigmentosa, Macular Degeneration
- Trial name
- NCT00559234
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)
Open-angle Glaucoma, Ocular Hypertension
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or…
- Trial name
- NCT04499248
- Testing
- AGN-193408 SR, Lumigan, Lumigan Vehicle
- Where
- 49 sites in United States, Japan
- Volunteers
- 100 people
- Sponsor
- AbbVie
Glaucoma
Comparison of Topical Anesthesia and Analgosedation in Micropulse Transscleral Glaucoma Treatment
Topical Anesthesia will be compared to Analgosedation for pain control in Micropulse Transscleral Laser Treatment for Glaucoma (MP-TLT).
- Trial name
- TAPMP3 (NCT04448080)
- Testing
- Micropulse Transscleral Laser Therapy for Glaucoma (MP-TLT)
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University of Zurich
Glaucoma, Ocular Hypertension
Safety and Efficacy of Triple Combination Therapy in Patients With Glaucoma or Ocular Hypertension
This study will investigate the safety and efficacy of Triple Combination Therapy (bimatoprost/brimonidine tartrate/timolol fixed combination ophthalmic solution) in patients with glaucoma or ocular hypertension who have elevated…
- Trial name
- NCT01216943
- Testing
- bimatoprost/brimonidine tartrate/timolol fixed combination ophthalmic solution
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Allergan
Glaucoma, Neovascular, Vascular Endothelial Growth Factor Overexpression
Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT
To prospect studying the efficacy and safety of treating NVG with the intracameral versus the intravitreal injection of Bevacizumab.
- Trial name
- NCT03648814
- Testing
- Intracameral injection, Intravitreal injection
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Prince of Songkla University
Glaucoma, Open-Angle, Failing Bleb Following Trabeculectomy
Treatment of Failing Blebs With Ranibizumab
This study was designed to evaluate the efficacy and safety in the use of Ranibizumab, an effective vascular endothelial growth factor (VGEF) inhibitor, in treating patients with a failing bleb, characterized by increased…
- Trial name
- NCT00570726
- Testing
- Ranibizumab (Lucentis)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The New York Eye & Ear Infirmary
Primary Open-Angle Glaucoma
GlaucoT Glaucoma Treatment Glasses in the Treatment of Primary Open-Angle Glaucoma
Glaucoma is a chronic and progressive optic neuropathy characterized by degeneration of ganglion cells and axons with loss of visual function.
- Trial name
- GlaucoT (NCT05253534)
- Testing
- GlaucoT Glaucoma Treatment Device
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Glaucot Teknoloji Anonim Sirketi
Open-angle Glaucoma, Ocular Hypertension
Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after six weeks of treatment in Caucasian and Japanese subjects.
- Trial name
- NCT00047606
- Testing
- IOP Lowering Medications
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Ocular Hypertension, Primary Open Angle Glaucoma
Glaucoma Adherence Study
The purpose of this study is evaluate adherence to DuoTrav® when reinforced by the use of the Travalert™ Dosing Aid.
- Trial name
- GAS (NCT00676637)
- Testing
- Travoprost 0.004%/timolol 0.05% fixed combination eye drops (DuoTrav), Travalert Dosing Aid
- Where
- 4 sites in France, Italy and 2 more
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Neovascular Glaucoma
Minimally Invasive Suprachoroidal Drainage for the Treatment of Neovascular Glaucoma
To explore the efficacy and safety of minimally invasive suprachoroidal drainage for the treatment of advanced neovascular glaucoma
- Trial name
- NCT07201415
- Testing
- minimally invasive suprachoroidal drainage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongnan Hospital
Open-angle Glaucoma
Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost
Evaluation of the intraocular pressure (IOP) lowering effect of two iStent inject devices versus medical therapy in eyes of subjects with primary open-angle glaucoma, pseudoexfoliative glaucoma, or ocular hypertension naïve to…
- Trial name
- NCT01444040
- Testing
- iStent inject, Travoprost
- Where
- Armenia
- Volunteers
- 196 people
- Sponsor
- Glaukos Corporation
Glaucoma
The Support, Educate, Empower (SEE) Program
This study will test whether the Support, Educate, Empower (SEE) personalized Glaucoma Coaching Program improves eye drop medication adherence among glaucoma patients compared to enhanced standard care in a randomized controlled…
- Trial name
- SEE (NCT04735653)
- Testing
- Personalized Glaucoma Coaching, Enhanced Standard care
- Where
- 2 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Michigan
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Glaucoma, Angle-Closure
Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma
This study will evaluate the safety and IOP-lowering effectiveness of XEN in patients with Angle Closure Glaucoma.
- Trial name
- NCT03362931
- Testing
- XEN45
- Where
- 16 sites in Australia, Canada and 4 more
- Volunteers
- 65 people
- Sponsor
- Allergan
Glaucoma
Effects of Anti-Glaucoma Medications on the Ocular Surface
The purpose of the study is to compare the efficacy of FDA-approved Travoprost (Travatan Z) and Latanoprost (Xalatan)as anti-glaucoma treatment.
- Trial name
- BAK (NCT01315574)
- Testing
- Travoprost, Latanoprost
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Retinal Degeneration, Primary Open-Angle Glaucoma
Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Glaucomatous Neurodegeneration
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc) from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT02144103
- Testing
- Subtenon administration of autologous ADRC, Liposuction, ADRC isolation
- Where
- 2 sites in Russia
- Volunteers
- 16 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Glaucoma Medication Adherence, Glaucoma Patients
Eye Patient Adherence and Compliance Study
This study looks at ways to help people with glaucoma take their eye drops regularly and attend their clinic appointments. Each participant will be asked about the main challenges they face, such as forgetfulness, difficulty…
- Trial name
- EYE-PACIP (NCT07793474)
- Testing
- Eye Droppers, Eye Educate, Eye Coordinate
- Where
- Canada
- Volunteers
- 189 people
- Sponsor
- St. Joseph's Healthcare Hamilton