Clinical trials: Glaucoma Therapy
Glaucoma
Micropulse Transscleral Diode Laser Cyclophotocoagulation (MP-TSCPC) as a Treatment Modality for Glaucoma Patients
The study objective was to evaluate the efficacy and safety of transscleral cyclophotocoagulation (TSCPC) using micropulse diode laser treatment in patients with various types of glaucoma.
- Trial name
- NCT05299281
- Testing
- Micropulse transscleral cyclophotocoagulation (MP-TSCPC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Uddevalla Skövde Transscleral Micropulse Study
Micro pulse transscleral laser treatment (MP-TLT) is a relatively new method to reduce the intraocular pressure (IOP) in glaucoma.
- Trial name
- USTMS (NCT05557721)
- Testing
- Topical lidocaine, MP-TLT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Glaucoma
Rocklatan® Evaluation
The objective of this study is to evaluate the IOP-lowering effect when subjects are switched from various latanoprost-based regimens to Rocklatan.
- Trial name
- NCT05283395
- Testing
- Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution
- Where
- 21 sites in United States
- Volunteers
- 136 people
- Sponsor
- Aerie Pharmaceuticals
Vitreoretinal Disease, Ocular Hypertension
IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids
Intravitreal triamcinolone acetonide (IVTA) is a commonly employed treatment for various vitreoretinal disorders. However, approximately 23% to 50% of patients who receive IVTA develop ocular hypertension after the drug is…
- Trial name
- IVTA:PRE-TREAT (NCT00744666)
- Testing
- Prednisolone 1% topical eye drops
- Where
- 4 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Hotel Dieu Hospital
Glaucoma
Effects of a PF Ophthalmic Solution Containing HA0.4% and TAU 0.5%
Eligible patients underwent evaluation of ocular surface parameters by Ocular Surface Disease Index (OSDI) and Glaucoma Symptom Scale (GSS) questionnaires, Break Up Time test (BUT), Schirmer I test, corneal and conjunctival…
- Trial name
- NCT03480295
- Testing
- Hyaluronic acid 0.4% and Taurine 0.5%, Hyaluronic acid 0.2%
- Volunteers
- 39 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Pediatric Aphakic Glaucoma
Trabeculectomy With MMC Versus Ahmed Glaucoma Implant for Treatment of Pediatric Aphakic Glaucoma
In this randomized clinical trial we compare trabeculectomy with mitomycin-C (T+MMC) and Ahmed glaucoma implant (AGI) in treatment of aphakic glaucoma in children under 16 years of age.Complete and qualified success were defined…
- Trial name
- NCT00371072
- Testing
- trabeculectomy with mitomycin-C
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
A Multicenter Evaluation of Methods to Reduce Hyperemia Associated With Bimatoprost Therapy for Glaucoma or Ocular Hypertension
Evaluate the incidence of hyperemia in patients using bimatoprost and to determine if simple interventions reduce its incidence and to assess the value of detailed instruction in increasing patient compliance and willingness to…
- Trial name
- NCT00348062
- Testing
- Bimatoprost
- Where
- United States
- Sponsor
- Innovative Medical
Glaucoma, Blindness, Acquired
Laminar Drainage Implant: Safety of a Novel Surgical Treatment for Refractory Glaucoma.
Purpose: To assess the feasibility of a surgical technique and present the preliminary safety results of a new glaucoma device devoid of a tube in painful blind eyes.
- Conditions
- Glaucoma, Blindness, Acquired, End-Stage Glaucoma, Glaucoma Traumatic
- Trial name
- NCT03166566
- Testing
- Laminar drainage implant surgery.
- Volunteers
- 15 people
- Sponsor
- Federal University of Minas Gerais
Intraocular Pressure
Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG)
To evaluate the IOP (Intraocular Pressure) lowering efficacy and safety of Brinzolamide 1.0% (Azopt), dosed twice daily as adjunctive therapy in patients treated with Travoprost 0.004% (Travatan) once daily.
- Trial name
- NCT00758342
- Testing
- Travoprost 0.004% + Brinzolamide 1.0%, Travoprost 0.004% + Tears Natural
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
Phase 3 Study Comparing IOP Lowering in OAG or OH in Japanese Subjects C-01-98
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after twelve months of treatment in Japanese subjects.
- Trial name
- NCT00047593
- Testing
- IOP Lowering Medications
- Where
- 3 sites in United States
- Sponsor
- Alcon Research
Subthreshold Diode Laser, Trabeculotomy
Subthreshold Diode Laser Versus Trabeculotomy in Treatment of Advanced Primary Open Angle Glaucoma
This study aimed to compare between subthreshold diode laser and trabeculotomy in treatment of advanced primary open angle glaucoma throughout 12 months follow-up.
- Conditions
- Subthreshold Diode Laser, Trabeculotomy, Advanced Primary Open Angle Glaucoma, Intraocular Pressure
- Trial name
- NCT07591662
- Testing
- Subthreshold diode laser, Trabeculotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Open-angle Glaucoma, Ocular Hypertension
Phase III Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients
The purpose of this study is to determine the safety and IOP-lowering ability of a glaucoma therapy in patients with open-angle glaucoma or ocular hypertension
- Trial name
- NCT00288951
- Testing
- Travoprost 0.004% with and without BAK
- Volunteers
- 690 people
- Sponsor
- Alcon Research
Glaucoma
The Effect of Education on Patient Compliance
With patient education, the compliance with glaucoma medications will increase.
- Trial name
- NCT00376974
- Testing
- American Academy of Ophthalmology Glaucoma Educational Tape
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Glaucoma, Medication Adherence
The iD2: A Smart Eye Drop Cap Monitor for Eye Drop Adherence
Most patients with glaucoma use eye drops to lower their intraocular pressure. However, poor adherence to prescribed eye drop regimens can lead to significant loss of vision-related quality of life.
- Trial name
- NCT07664943
- Testing
- Eye drop cap monitor
- Volunteers
- 100 people
- Sponsor
- Universal Adherence LLC
Open Angle Glaucoma, Eye Diseases
Effect of Repeated Low-Level Red-Light Therapy on Visual Field Damage in Primary Open-angle Glaucoma
The purpose of this study is to investigate the effect of repeated low-level red-light therapy on existing visual field damages in primary open-angle glaucoma patients.
- Trial name
- NCT05309811
- Testing
- RLRL therapy, Routine IOP-lowering medications
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Primary Open-Angle Glaucoma (POAG)
Personalized Mobile Reminders for Medication Adherence and Intraocular Pressure Control in Primary Open-Angle Glaucoma
This study evaluates whether a personalized mobile reminder program improves treatment adherence and clinical outcomes in adults with primary open-angle glaucoma (POAG) using topical antiglaucoma eye drops.
- Trial name
- M-GLAUCO (NCT07480577)
- Testing
- Digital Reminder Intervention
- Volunteers
- 84 people
- Sponsor
- Sakarya Yenikent State Hospital
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Open-angle Glaucoma, Ocular Hypertension
A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of the study is to evaluate the safety and effectiveness of an investigational therapy for treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00293787
- Testing
- Travoprost 0.004% / Timolol 0.5% Ophthalmic Solution, Timolol Vehicle, Latanoprost 0.005% Ophthalmic Solution (XALATAN)
- Volunteers
- 156 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada
The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior brimonidine 0.2%/timolol 0.5% fixed combination (COMBIGAN®) therapy in patients with open-angle glaucoma or ocular…
- Conditions
- Glaucoma, Ocular Hypertension, Open-angle Glaucoma
- Trial name
- NCT01415401
- Testing
- Brinzolamide 1% / timolol 0.5% maleate fixed combination
- Volunteers
- 57 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
Phase II Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients
To determine the safety and IOP-lowering ability of a test compound in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00069719
- Testing
- Glaucoma therapy
- Where
- United States
- Sponsor
- Alcon Research