Clinical trials: Glaucoma Therapy
Glaucoma, Open-Angle, Ocular Hypertension
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
This is a randomized, double-blind, two-treatment, single-period, parallel design, multiple dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical endpoint in subjects with chronic open-angle…
- Trial name
- NCT05401357
- Testing
- Test - Bimatoprost 0.01% Ophthalmic Solution, Reference - LUMIGAN® (Bimatoprost 0.01% Ophthalmic Solution)
- Where
- 9 sites in United States
- Volunteers
- 168 people
- Sponsor
- Amneal Pharmaceuticals, LLC
Ocular Hypertension, Primary Open Angle Glaucoma
Glaucoma Adherence Study, Spain
The purpose of this study is to evaluate adherence to DuoTrav® when reinforced by the use of the Travalert™ Dosing Aid.
- Trial name
- GAS (NCT00680329)
- Testing
- Travoprost 0.004%/timolol 0.05% fixed combination eye drops (DuoTrav), Travalert Dosing Aid
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Open-angle Glaucoma, Ocular Hypertension
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00314171
- Testing
- Brinzolamide 10 mg/ml + Timolol 5 mg/ml eye drops, suspension, Dorzolamide 20 mg/ml + Timolol 5 mg/ml eye drops, solution (COSOPT)
- Volunteers
- 437 people
- Sponsor
- Alcon Research
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of a Novel Glaucoma Tube Shunt Implant for Intraocular Pressure Control in Eyes With Refractory Glaucoma
The aim of this study is to determine the effectiveness of lowering intraocular pressure and safety profile of the Paul Glaucoma Implant (Advanced Ophthalmic Innovations, Singapore).
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Surgery, Intraocular Pressure
- Trial name
- NCT04297930
- Testing
- Paul Glaucoma Implant Surgery
- Where
- Singapore
- Volunteers
- 82 people
- Sponsor
- National University Hospital, Singapore
Glaucoma
Switching From Preserved to Preserved-free Treatments for Glaucoma.
A 1-year prospective, randomized, investigator-masked trial comparing the confocal and clinical effects of treatment with unpreserved prostaglandins (tafluprost) versus preserved prostaglandins (latanoprost) in newly-diagnosed…
- Trial name
- NCT01433900
- Testing
- Tafluprost, Latanoprost
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Paolo Fogagnolo
Glaucoma
Compliance and Administration Technique in Topical Drug Therapy of Glaucoma
Clinic-based evaluation of patients compliance with topical medications in the treatment of glaucoma. Also assessing effectiveness of delivery techniques among these patients.
- Trial name
- NCT00303121
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Toronto
Primary Open-Angle Glaucoma (POAG)
MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)
Hypothesis: The use of neurocytoprotectors helps restore the functional activity of mitochondria, improve the nervous activity of the retina and optic nerve, and stabilize the glaucomatous process.
- Trial name
- NCT06437639
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Pharmasoft
Glaucoma, Glaucoma, Open-Angle
Dresden Glaucoma and Treatment Study (DGTS)
To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Low Tension
- Trial name
- NCT02959242
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Glaucoma
Study on Incentives for Glaucoma Medications Adherence
Glaucoma topical eye medications, when adhered to, are effective at controlling disease progression. Yet evidence shows that many glaucoma patients have incomplete adherence to medications, with disease progression resulting in…
- Trial name
- SIGMA (NCT02271269)
- Testing
- Value Pricing Subsidies
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Duke-NUS Graduate Medical School
Open-Angle Glaucoma, Surgery
Goniocurettage as First Choice of Surgical Treatment in Chronic Open-Angle Glaucoma: Outcomes and Complications
The study has the purpose to evaluate the effectiveness and safety of the goniocurettage as a first choice of surgical treatment for primary open-angle glaucoma (POAG) in patients with good vision.
- Trial name
- GC (NCT01511094)
- Testing
- Goniocurettage
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Federal University of Minas Gerais
Glaucoma
The Laser in Pseudoexfoliation (LIP) Study
A number of large clinical trials have found pseudoexfoliation (PXF) to be a major risk factor for glaucoma progression and risk of blindness.
- Trial name
- LIP (NCT01704989)
- Testing
- SLT Laser, Prostagladin
- Where
- Canada
- Sponsor
- Nova Scotia Health Authority
Glaucoma, Ocular Hypertension
An Efficacy and Tolerability Study of TRAVATAN® Versus LUMIGAN®
The purpose of this study is evaluate effects of TRAVATAN® versus LUMIGAN® on intraocular pressure (IOP) and ocular surface and inflammatory biomarkers.
- Trial name
- NCT01664039
- Testing
- Travoprost 0.004% ophthalmic solution, Bimatoprost 0.01% ophthalmic solution
- Volunteers
- 104 people
- Sponsor
- Alcon Research
Glaucoma, Acupuncture
Acupuncture as Adjuvant Therapy for Glaucoma - Protocol for a Randomized Controlled Trial
This clinical trial used acupuncture as an adjunctive treatment for glaucoma patients. A randomized, controlled trial involving 50 subjects will be conducted and observed for 12 weeks to evaluate the clinical efficacy of…
- Conditions
- Glaucoma, Acupuncture, Intraocular Pressure
- Trial name
- NCT05753137
- Testing
- Acupuncture
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Glaucoma Treatment Using Focused Ultrasound
UCP Glaucoma Treatment for Primary Glaucoma in China
To collect safety and efficacy data on Ultrasound Cycle Plasty treatment (UCP) in primary glaucoma asian patients.
- Trial name
- NCT04145830
- Testing
- Ultrasound Cyclo Plasty (UCP)
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- EyeTechCare
Angle Closure Glaucoma
Combined Phacoemulsification and Diode Laser Therapy in Chronic Angle Closure Glaucoma
comparing different types of cuclophotocoagulation with cataract extraction to cataract extraction and goniocynechiolysis in cases of chronic angle closure glaucoma
- Trial name
- NCT05576493
- Testing
- phaco+MP-TSCPC, phaco+TSCPC, phaco+endocyclophotocoagulation
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Cairo University
Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome
Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy
The main aim of this investigation is to evaluate the effect of the preservative-free ophthalmic solution IRIDIUM® A gel on the ocular surface of patients with glaucoma or OHT and concomitant DES under multiple long-term topical…
- Conditions
- Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome, Ocular Hypertension and Concomitant Dry Eye Syndrome, Multiple Long-term Topical Hypotensive Therapy
- Trial name
- NCT06190028
- Testing
- Iridium A Gel
- Where
- 3 sites in Italy
- Volunteers
- 65 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Glaucoma, Ocular Hypertension
Phase 2b Study Evaluating Safety and Efficacy of OTX-TP Compared to Timolol Drops in the Treatment of Subjects With Open Angle Glaucoma or Ocular Hypertension
To evaluate the safety and IOP lowering efficacy of OTX-TP, a sustained release travoprost drug product, placed in the canaliculus of the eyelid compared to Timolol Maleate Ophthalmic Solution, 0.5% in the treatment of subjects…
- Trial name
- NCT02312544
- Testing
- OTX-TP, Timolol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Ocular Therapeutix, Inc.
Glaucoma
Safety, Efficacy Assessment of Geltim LP® 1 mg/g in Ocular Hypertensive or Glaucomatous Patients.
This phase IV study aims to assess the safety and the efficacy in intra ocular pressure of Geltim LP® 1 mg/g (0.1% unpreserved timolol maleate gel) in glaucomatous patients initially treated and stabilised by monotherapy of…
- Trial name
- T1030 (NCT01155219)
- Testing
- Geltim LP 1 mg/g, Xalatan
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Laboratoires Thea
Glaucoma, Primary Open Angle
Excimer Laser Trabeculostomy Glaucoma Treatment Study
Evaluation of the safety and effectiveness of the ELIOS System procedure to reduce intraocular pressure (IOP) in adult subjects with mild to moderate primary open-angle glaucoma (POAG) undergoing cataract surgery
- Trial name
- ELTGTS (NCT04899063)
- Testing
- ELIOS Procedure
- Where
- 20 sites in United States
- Volunteers
- 318 people
- Sponsor
- Elios Vision, Inc.
Glaucoma, Ocular Surface Disease
From Preserved, to Preservative-free Cyclosporine 0.1% Enhanced Triple Glaucoma Therapy
There is a lack of evidence on the impact of switching from a combined preserved anti-glaucoma regimen to a preservative-free (PF) one, while employing sufficiently robust OSD metrics.
- Trial name
- NCT04673604
- Testing
- Assessment of ocular surface staining (Oxford score 0-15 scale), mean diurnal intraocular pressure-lowering
- Where
- Greece
- Volunteers
- 42 people
- Sponsor
- Aristotle University Of Thessaloniki