Clinical trials: Glaucoma Therapy
Adherence to Glaucoma Therapy
Real-world Study to Assess Adherence to IOP Lowering Therapy in Patients With Glaucoma or Ocular Hypertension Using CONNECTDROP®
The goal of this real-life, national, multicentre, prospective clinical investigation is to describe the adherence rate over time in patients with glaucoma or OHT already treated with IOP-lowering eye drops using connected device…
- Trial name
- NCT07206628
- Where
- 15 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Laboratoires Thea
Glaucoma
Safety and Efficacy of Changing to DuoTrav From Prior Therapy
The purpose of this study to assess the safety and efficacy of changing to DuoTrav® from prior bimatoprost 0.03%/timolol 0.5% (used concomitantly or in a fixed combination) pharmacotherapy in uncontrolled patients with open-angle…
- Trial name
- NCT01230736
- Testing
- Travoprost 0.004%/Timolol 0.5% Fixed Combination eye drops solution (Duotrav®)
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)
Evaluate the effectiveness of dorzolamide-timolol (Cosopt®) as first line therapy in reducing intraocular pressure in patients with untreated Open angle glaucoma (OAG) or Ocular hypertension (OH).
- Trial name
- NCT00546286
- Testing
- dorzolamide hydrochloride (+) timolol maleate, Comparator: dorzolamide HCl/timolol maleate + prostaglandin
- Volunteers
- 170 people
- Sponsor
- Merck Sharp & Dohme LLC
Age Related Macular Degeneration, Diabetic Retinopathy
Strategies for Improving Linkage-to-Care After Eye Disease Screening
The goal of this randomized, parallel-group, controlled trial is to compare methods of improving linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital…
- Conditions
- Age Related Macular Degeneration, Diabetic Retinopathy, Glaucoma
- Trial name
- NCT06943599
- Testing
- Text Message Reminder, Health Worker Visit
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of California, San Francisco
Glaucoma
Surgical Retinotomy for the Treatment of Glaucoma
Glaucoma is a leading cause of blindness worldwide. It is caused by persistently elevated intraocular pressure causing progressive visual field loss.
- Trial name
- NCT03798145
- Testing
- Surgical Retinotomy
- Sponsor
- Stanford University
Eye Drops Self-instillation, Glaucoma
Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS
Glaucoma is a large group of intraocular pressure-sensitive conditions that can cause progressive retinal ganglion cell (RGC) damage/loss and ultimately results in visual field loss that can produce irreversible blindness.
- Conditions
- Eye Drops Self-instillation, Glaucoma, Dry Eye
- Trial name
- Zolymbus (NCT07845357)
- Testing
- preservative free ZOLYMBUS™ 0.01%.
- Volunteers
- 40 people
- Sponsor
- Southern College of Optometry
Healthy
Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Long term treatment with anti-glaucomatous drugs has been shown to increase the incidence of dry eye syndrome with all known consequences such as ocular discomfort and epithelial keratitis.
- Trial name
- NCT01746602
- Testing
- Timoptic® 0.5%, Timophtal sine® 0.5%, Genteal HA®
- Where
- Austria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Open Angle Glaucoma (OAG)
DSLT Performance in Treatment-naïve Patients With Newly Diagnosed Open Angle Glaucoma
DSLT demonstrates a ≥ 20% reduction of IOP from pre-treatment baseline in POAG patients naïve of previous glaucoma treatment at 12 months.
- Trial name
- NCT06933836
- Testing
- DSLT enables newly diagnosed patients to remain well controlled and off medications
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Barnet Dulaney Perkins Eye Centers
Ocular Hypertension, Suspect Glaucoma
Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects
The goal of this clinical trial is to compare participants treated with latanoprost to those treated with Rocklatan (netarsudil/latanoprost) to determine whether the addition of netarsudil results in greater improvements in…
- Trial name
- NCT04401982
- Testing
- Rocklatan (Netarsudil 0.02%/ latanoprost 0.005), Latanoprost (0.005%)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Glaucoma
Observational Study of How Patients Take Eye Drops
This study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation…
- Trial name
- NCT00750646
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Glaucoma
Functional and Structural Imaging for Glaucoma
The specific aims of the clinical studies are to: Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion.
- Trial name
- FSOCT (NCT01957267)
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Treatment Outcome
Effect of Latanoprost on Optic Nerve Perfusion
46 eyes of 23 patients have been treated with topical Latanoprost 0.005 %. visual field was performed on all eyes. NFLT was measured using OCT. Radial peripapillary capillary (RPC) vascular density was measured using OCTA .
- Trial name
- NCT06629129
- Testing
- Latanoprost (0.005%)
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Zagazig University
Glaucoma
24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice
The primary objective of this crossover 24-hour Intraocular Pressure (IOP) trial is to compare the control obtained after 3 months of therapy with the bimatoprost/timolol fixed combination (BTFC, Ganfort) given once in the…
- Trial name
- NCT01448837
- Testing
- Bimatoprost/Timolol, 24-hour intraocular pressure monitoring, Latanoprost, 24-hour intraocular pressure monitoring
- Where
- Greece
- Volunteers
- 37 people
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma, Glaucoma Eye
MicroPulse TLT - UK Study
This Prospective Interventional Study will assess the efficacy of MPTLT in the UK.
- Conditions
- Glaucoma, Glaucoma Eye, Glaucoma, Open-Angle, Glaucoma Secondary
- Trial name
- MPTLTUKS (NCT05593354)
- Testing
- Micropulse Transscleral laser therapy
- Volunteers
- 250 people
- Sponsor
- Imperial College Healthcare NHS Trust
Glaucoma
Bimatoprost Monotherapy vs. Dual Therapy With Travoprost and Timolol in Patients With Glaucoma and Ocular Hypertension
Evaluate the IOP-lowering efficacy and quality of life in patients using bimatoprost 0.03% monotherapy versus dual therapy with travoprost 0.004% and timolol 0.5% for the treatment of glaucoma or ocular hypertension.
- Trial name
- NCT00348023
- Testing
- Bimatoprost 0.03%, Travoprost 0.004%, Timolol 0.5%
- Where
- United States
- Sponsor
- Innovative Medical
Open Angle Glaucoma, Ocular Hypertension
180 Degree vs. 360 Degree Selective Laser Trabeculoplasty as Initial Therapy for Glaucoma
Selective laser trabeculoplasty (SLT) is a well-recognized way to lower eye pressure in treatment of glaucoma. This treatment is performed for 180 degrees or 360 degrees, and studies at academic centers have shown mixed results…
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Glaucoma, Open Angle, Pseudo-exfoliative, Pigment Dispersion Syndrome
- Trial name
- NCT02628223
- Testing
- Selective Laser Trabeculoplasty, Neodymium:Yttrium Aluminum Garnet (YAG) laser
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Temple University
Glaucoma
Trabeculectomy Versus Canaloplasty to Treat Glaucoma
The aim of the study is to investigate pressure lowering effect of two surgical methods canaloplasty and trabeculectomy in patients with open angle glaucoma, in which under local pressure lowering therapy the progression of the…
- Trial name
- NCT00854256
- Testing
- Canaloplasty, Trabeculectomy with mitomycin C
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Glaucoma Therapy
Citicoline and Filtration Surgery
Glaucoma is a group of conditions characterised by a progressive loss of retinal ganglion cells (RGCs) and their axons, leading to characteristic changes in the optic nerve head and the retinal nerve fibre layer.
- Trial name
- NCT07567651
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Glaucoma, Ocular Hypertension
Long-Term Non-Interventional Latanoprost Study
This is a non-interventional, prospective, longitudinal cohort study. A total of 150 pediatric subjects with glaucoma or elevated intraocular pressure, including 75 latanoprost-treated subjects and 75 non-topical prostaglandin…
- Trial name
- LYNX (NCT01265719)
- Testing
- No intervention other than routine medical care
- Where
- 29 sites in Belgium, Colombia and 12 more
- Volunteers
- 175 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma
Clinical Evaluation of Efficacy of SLT to Topical Medication in Lowering IOP
The purpose of this study is to compare Selective laser trabeculoplasty (SLT) and topical medications for initial treatment of open-angle glaucoma /Ocular Hypertension based on intraocular pressure reduction, treatment side…
- Trial name
- NCT01639807
- Testing
- Latanoprost, SLT
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Aurolab