Clinical trials: Glial Tumor
Brain and Central Nervous System Tumors
Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors
RATIONALE: Perfusion magnetic resonance imaging may be an effective method of measuring the growth of blood vessels in brain tumors. These measurements may help doctors better diagnose and treat brain tumors.
- Trial name
- NCT00005790
- Testing
- laboratory biomarker analysis, biopsy, magnetic resonance imaging
- Sponsor
- Northwestern University
Astrocytoma, IDH-Mutant, Grade 3
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation.
- Trial name
- NCT07215910
- Testing
- Intensity-Modulated Radiation Therapy, Volume Modulated Arc Therapy, Pencil Beam Scanning
- Where
- 177 sites in United States
- Volunteers
- 408 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Glioblastoma Multiforme
Ketogenic Diet Adjunctive to Salvage Chemotherapy for Recurrent Glioblastoma:a Pilot Study
Recently, ketogenic diet has been recognized a useful treatment strategy for glioblastoma in vitro. Therefore, the purpose of the study is to evaluate the safety and efficacy of ketogenic adjuvant to salvage chemotherapy for…
- Trial name
- KGDinrGBM (NCT02939378)
- Testing
- Ketogenic diet, Standard diet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Song Lin
Propofol, Glioma
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity.
- Conditions
- Propofol, Glioma, Auditory Event-related Potential (AERP), Electroencephalogram (EEG)
- Trial name
- NCT05352685
- Testing
- Propofol Injection
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Brain and Central Nervous System Tumors
Carmustine and O(6)-Benzylguanine in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. O(6)-benzylguanine may increase the effectiveness of carmustine by making tumor cells more sensitive to the…
- Trial name
- NCT00046878
- Testing
- O6-benzylguanine, carmustine
- Sponsor
- Duke University
Glioblastoma Multiforme
Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning
This study is investigating the use of a computer algorithm to analyze scans of the brain before surgery to predict how a person's tumor will respond to treatment.
- Trial name
- NCT05864976
- Testing
- Support Vector Machine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Glioblastoma, Anaplastic Astrocytoma
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation…
- Conditions
- Glioblastoma, Anaplastic Astrocytoma, Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- NCT06108206
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Low-grade Gliomas
Tarceva/Rapamycin for Children With Low-grade Gliomas With or Without Neurofibromatosis Type 1 (NF1)
This study will evaluate the feasibility of combining two drugs, Tarceva (an anti-EGFR agent), and Rapamycin (an mTOR inhibitor), in children with progressive low-grade gliomas who have failed initial conventional treatment.
- Trial name
- NCT00901849
- Testing
- Tarceva and Rapamycin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Roger Packer
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Ependymoma, Brainstem Glioma
A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas
Background: Children with brain tumors often have magnetic resonance imaging (MRI) scans to see if the tumor has responded to therapy or to see if the tumor has grown.
- Conditions
- Ependymoma, Brainstem Glioma, Astrocytoma, Glioblastoma Multiforme
- Trial name
- NCT01117155
- Sponsor
- National Cancer Institute (NCI)
Glioblastoma
Treatment Intensification With Temozolomide in Adults With a Glioblastoma
Due to conflicting data on the optimal moment to start TMZ chemotherapy and the impact of prolongation of the adjuvant phase with TMZ, the ANOCEF (Association des Neuro-Oncologues d'Expression Francophone) group proposes this…
- Trial name
- StrateGlio (NCT03663725)
- Testing
- Intensified protocol, Stupp protocol
- Where
- 17 sites in France
- Volunteers
- 486 people
- Sponsor
- Centre Oscar Lambret
Brain Cancer, Brain Neoplasm
Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects
Glioblastoma (GBM) and gliosarcoma (GS) are the most common and aggressive forms of malignant brain tumor in adults and can be resistant to conventional therapies.
- Conditions
- Brain Cancer, Brain Neoplasm, Glioma, Glioblastoma
- Trial name
- CAPTIVE (NCT02798406)
- Testing
- DNX-2401, pembrolizumab
- Where
- 15 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- DNAtrix, Inc.
Thrombocytopenia
Study of Avatrombopag for Temozolomide-induced Thrombocytopenia in Glioma (APATIT-G)
The purpose of this study is to determine if using avatrombopag in patients with thrombocytopenia due to temozolomide treatment can safely improve a patient's platelet count and allow the patient to complete the temozolomide…
- Trial name
- NCT04931849
- Testing
- Avatrombopag
- Where
- United States
- Sponsor
- University of Rochester
Glioma of Brain
Early Temozolomide in Patients With High-Grade Gliomas in Rehabilitation
The purpose of this study is to investigate the feasibility of a possible treatment regimen that could be used to delay tumor progression in patients with glioblastoma.
- Trial name
- NCT03796507
- Testing
- Temozolomide
- Where
- United States
- Sponsor
- University of Rochester
Glioblastoma, Radiotherapy
Study of Prognostic Biomarkers of Survival at 6 Months for Patients Treated With Bevacizumab Glioblastomas in First Relapse After Failure of Radiochemotherapy
No predictive factors are known for the response to the bevacizumab anti-angiogenic molecule (Avastin) given in the event of relapse of glioblastoma (GBM) following radiochemotherapy.
- Conditions
- Glioblastoma, Radiotherapy, Chemotherapy
- Trial name
- SPECTROBEVA (NCT03144167)
- Testing
- Analysis of spectroscopic biomarkers of proliferation for six-month survival
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Patients With Resectable Brain Tumors
3D Ultra Sound for Resection of Brain Tumors
Phase 3 randomized open labeled trials will evaluate the 3 D navigable ultrasound (SonoWand) in improving the extent of resection in intra-axial brain tumors. All patients will undergo resective surgery.
- Trial name
- SonoRCT (NCT02150564)
- Testing
- Sonowand, Navigation
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Tata Memorial Hospital
Diffuse Intrinsic Pontine Glioma
CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)
This is a Phase I and Early Efficacy Study of Convection Enhanced Delivery (CED) of irinotecan liposome injection (nal-IRI) Using Real Time Imaging with Gadolinium in Children with Diffuse Intrinsic Pontine Glioma who have…
- Trial name
- NCT03086616
- Testing
- Convection Enhanced Delivery (CED) of Nanoliposomal irinotecan (nal-IRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sabine Mueller, MD, PhD
Glioblastoma
Precoce Medical Care by the Mobil Support for Patients With Glioblastoma
Most patients with glioblastoma have impaired cognitive function, autonomy, and quality of life. This clinical situation, combined with a limited life expectancy, makes the preservation of quality of life a major objective, in a…
- Trial name
- GLIOSUPPORT (NCT04516733)
- Testing
- supportive care
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Neuroblastoma, Medulloblastoma
Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer
The purpose of this study is to test the feasibility (ability to be done) of experimental technologies to determine a tumor's molecular makeup (gene expression profile) and mutations.
- Conditions
- Neuroblastoma, Medulloblastoma, Brain Tumors, Rare Tumors
- Trial name
- NCT01802567
- Testing
- Guided Therapy- Pediatric Gene Analysis Platform
- Where
- 13 sites in United States
- Volunteers
- 52 people
- Sponsor
- Giselle Sholler
Brain Tumour, High Grade Glioma
SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue
The objective of this clinical investigation is to assess the safety and performance of the SonoClear Acoustic Coupling Fluid (ACF).
- Conditions
- Brain Tumour, High Grade Glioma, Low-grade Glioma, Glioblastoma
- Trial name
- NCT04734444
- Testing
- SonoClear ACF
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 45 people
- Sponsor
- SonoClear AS