Clinical trials: Glial Tumors
Glioblastoma, GBM
Surgical Nivolumab And Ipilimumab For Recurrent GBM
This research trial is studying the safety and effectiveness of nivolumab in combination with ipilimumab and surgery when used in the treatment of recurrent glioblastoma.
- Conditions
- Glioblastoma, GBM, Glioblastoma Multiforme, Grade IV Astrocytoma
- Trial name
- NCT04606316
- Testing
- Nivolumab, Ipilimumab, Surgery
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Gilbert Youssef
Brain and Central Nervous System Tumors
Temozolomide in Treating Patients With Anaplastic Oligodendroglioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients with anaplastic…
- Trial name
- NCT00003465
- Testing
- temozolomide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Astrocytoma, Oligoastrocytoma
FET-PET for Diagnosis and Monitoring in Patients With Low Grade Glioma
The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within…
- Conditions
- Astrocytoma, Oligoastrocytoma, Oligodendroglioma
- Trial name
- NCT01089244
- Where
- 2 sites in Germany
- Volunteers
- 38 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Glioblastoma, High-Grade Glioma (WHO III-IV)
Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)
This is an open label, intra-patient dose escalation, to evaluate ADI-PEG 20, in combination with Temozolomide (TMZ) and radiation therapy (RT) in children, adolescents and young adult patients with newly diagnosed high grade…
- Conditions
- Glioblastoma, High-Grade Glioma (WHO III-IV), High-grade Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
- Trial name
- NCT07389278
- Testing
- ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Sabine Mueller, MD, PhD
Brain Tumor Treated With Cranial or Cranial-Spinal Radiation
Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma
A placebo controlled double blind crossover trial of metformin in 30 children treated with radiation for medulloblastoma - the most common malignant brain tumour.
- Trial name
- NCT02040376
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Glioblastoma
A Study Using Radiation Therapy and Temozolomide to Treat Glioblastoma in Patients Over 70
In this study we propose to determine outcomes of patients age 70 or older treated with radiation over 2 weeks given with temozolomide 75 mg/m2 daily during radiotherapy and as a post radiation treatment of 150 mg/m2 - 200 mg /m2…
- Trial name
- NCT01985087
- Testing
- Hypofractionated radiotherapy, Temozolomide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Louisville
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Glioblastoma
CAN008 Biomarker CD95 Ligand and CpG2 Methylation in Chinese Patients With Glioblastoma
This study was conducted on the post-operative tumor tissues from 62 GBM patients. 20 slices are necessary for all the CD95 and CpG2 test in the central lab by the methods of immunisation and DNA methylation.
- Trial name
- NCT03152708
- Volunteers
- 62 people
- Sponsor
- CANbridge Life Sciences Ltd.
Gliosarcoma, Recurrent Glioblastoma
NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery
The purpose of this research study is to evaluate the safety of the study drug, NU-0129, based on Spherical Nucleic Acid (SNA) platform when infused in patients with recurrent glioblastoma multiforme or gliosarcoma.
- Trial name
- NCT03020017
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Targeted Molecular Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Astrocytoma, Grade III, Glioblastoma
Multi-kinase Inhibitor TG02 (TG02) in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma.
This is a three parallel cohort, open-labeled, non-randomized, multicenter study. All three cohorts will enroll independently.
- Trial name
- STEAM (NCT03224104)
- Testing
- TG02, Radiation Therapy, Temozolomide
- Where
- 10 sites in Austria, France and 3 more
- Volunteers
- 71 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Glioblastoma Multiforme
Radiation Therapy and Temozolomide Followed by Temozolomide Plus Sorafenib for Glioblastoma Multiforme
The mechanism of action of sorafenib makes it an interesting drug to investigate in the treatment of patients with glioblastoma multiforme.
- Trial name
- NCT00544817
- Testing
- Radiation Therapy, Temozolomide, Sorafenib
- Where
- 10 sites in United States
- Volunteers
- 47 people
- Sponsor
- SCRI Development Innovations, LLC
Glioblastoma Multiforme, Astrocytoma, Grade IV
Neoepitope-based Personalized Vaccine Approach in Patients With Newly Diagnosed Glioblastoma
The early clinical development paradigm for chemotherapeutic agents has significantly influenced the development of therapeutic cancer vaccines.
- Trial name
- NCT02510950
- Testing
- Personalized peptide vaccine, Poly-ICLC, Temozolomide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Glioblastoma, Optic Neuropathy
Optic Neuropathy in 10 Patients With Glioblastoma Receiving Bevacizumab
Does treatment with bevacizumab (Avastin) in combination with prior or current radiotherapy lead to optic neuropathy?
- Trial name
- NCT01331616
- Testing
- Bevacizumab (Avastin)
- Sponsor
- West Penn Allegheny Health System
Glioblastoma
VXM01 Phase I Pilot Study in Patients With Operable Recurrence of a Glioblastoma
VXM01 phase I pilot study in patients with operable recurrence of a glioblastoma to examine safety, tolerability, immune and biomarker response to the investigational VEGFR-2 DNA vaccine VXM01
- Trial name
- NCT02718443
- Testing
- VXM01
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Vaximm GmbH
Brain Cancer, Arthritis, Rheumatoid
Assessing the Suitability of an Imaging Probe for Use in Clinical Cell and Gene Therapy Trials in Cancer and Rheumatoid Arthritis
The purpose of this study is to determine whether [18F]FHBG is suitable for use as an imaging probe in cancer or rheumatoid arthritis patients enrolled in cell or gene therapy trials.
- Conditions
- Brain Cancer, Arthritis, Rheumatoid, Central Nervous System Neoplasms, Glioma
- Trial name
- NCT00185848
- Testing
- [18F]FHBG
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sanjiv Sam Gambhir
Glioblastoma, Glioblastoma Multiforme
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
The trial is designed as a multicenter randomized controlled study. 246 patients with presumed Glioblastoma Multiforme in eloquent areas on diagnostic MRI will be selected by the neurosurgeons according the eligibility criteria…
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Astrocytoma, Grade IV
- Trial name
- SAFE (NCT03861299)
- Testing
- Awake craniotomy, Craniotomy under general anesthesia
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 246 people
- Sponsor
- Jasper Gerritsen
Glioblastoma Multiforme
Efficacy Study of CYT997 in Combination With Carboplatin in Glioblastoma
This study seeks to (i) determine the safe dose of CYT997 when given in combination with carboplatin in patients with relapsed glioblastoma multiforme (glioma) and (ii) to determine whether the combination of CYT997 with…
- Trial name
- NCT00650949
- Testing
- CYT997, Carboplatin
- Where
- 4 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Gilead Sciences
Glioblastoma, Cancer of Brain and Nervous System
Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma Multiform
The purpose of this study is to investigate the safety and effectiveness of a combination treatment for glioblastoma multiforme utilizing radiotherapy plus the FDA-approved chemotherapy drug temozolomide
- Conditions
- Glioblastoma, Cancer of Brain and Nervous System, Glioblastoma Multiforme
- Trial name
- Tx-Treatment (NCT01120639)
- Testing
- Temozolomide, Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Malignant Gliomas
Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I
The goal of this clinical research study is to find the highest tolerable dose of lenalidomide combined with Camptosar (irinotecan) as well as to see if this drug combination can help control malignant gliomas.
- Trial name
- NCT00671801
- Testing
- Irinotecan, Lenalidomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Glioma
MR Based Survival Prediction of Glioma Patients Using Artificial Intelligence
This registry aims to collect clinical, molecular and radiologic data including detailed survival data, clinical parameters, molecular pathology (1p/19q codeletion, MGMT methylation, IDH and TERTp mutations, etc) and…
- Trial name
- NCT04215211
- Testing
- Survival prediction for glioma patients
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
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