Clinical trials: Glioma
Melanoma, Medullary Thyroid Cancer
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Phase I study to examine safety of the addition of concurrent tarlatamab with standard palliative and consolidative RT regimens , with a main cohort of N=20-24 patients with extracranial anatomic radiation sites.
- Conditions
- Melanoma, Medullary Thyroid Cancer, Sinonasal Undifferentiated Carcinoma, Esthesioneuroblastoma
- Trial name
- RABBIT (NCT06814496)
- Testing
- Tarlatamab, Concurrent Radiation Therapy, Sequential Radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Brain and Central Nervous System Tumors
Bevacizumab and Sorafenib in Treating Patients With Recurrent Glioblastoma Multiforme
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00621686
- Testing
- bevacizumab, sorafenib tosylate
- Where
- 204 sites in United States
- Volunteers
- 54 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Quality of Life, Chemotherapeutic Toxicity
Complementary/Integrative Medicine for Brain Cancer Patients
Nearly a quarter of a million patients are diagnosed each year with tumors of the central nervous system, a third of them malignant.
- Conditions
- Quality of Life, Chemotherapeutic Toxicity, Radiation Toxicity
- Trial name
- NCT03185780
- Testing
- Acupuncture
- Sponsor
- The Chaim Sheba Medical Center
Glioma, Brain Metastases
nTMS for Motor Mapping of Rolandic Lesions
To compare presurgical motor mapping by navigated transcranial magnetic stimulation for surgery (nTMS) of rolandic lesions to surgery with mapping without implementing these data into neuronavigation as control.
- Trial name
- Motorstim (NCT02879682)
- Testing
- nTMS data available for the surgeon, nTMS data not available for the surgeon
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 330 people
- Sponsor
- Technical University of Munich
Glioma Glioblastoma Multiforme
Functional and Ultrasound Guided Resection of Glioblastoma
Functional and ultrasound-guided resection of glioblastoma: assessing the use of additional imaging during surgery to improve outcomes for patients with glioblastoma brain tumours
- Trial name
- FUTURE-GB (NCT05399524)
- Testing
- Standard of Care, Additional pre- and intra-operative imaging
- Where
- 24 sites in United Kingdom
- Volunteers
- 357 people
- Sponsor
- University of Oxford
High Grade Glioma
Personalized Translational Platform for Biomarker Discovery in Brain Tumors
The central hypothesis for this proposal is that multimodal (clinical, imaging, tissue) biomarkers will better predict early brain tumor response to treatments and will be more reliable prognostic markers in patients with…
- Trial name
- NCT01240161
- Testing
- FLT-PET/CT: (3'deoxy-3'-[(18)F] fluorothymidine) PET/CT
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Marcelo F. Di Carli, MD, FACC
Newly Diagnosed and Recurrent Glioblastoma
Dose Finding Study of [177Lu]Lu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma
This study will investigate different doses of [177Lu]Lu-NeoB in combination with RT and TMZ in participants with newly diagnosed glioblastoma, with methylated or unmethylated promoter, to assess the safety and efficacy of…
- Trial name
- NCT05739942
- Testing
- [177Lu]Lu-NeoB, [68Ga]Ga-NeoB, Temozolomide
- Where
- 16 sites in United States, France and 4 more
- Volunteers
- 42 people
- Sponsor
- Novartis Pharmaceuticals
Brain Stem Neoplasms, Glioma
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors
Background: IMC-A12 is an experimental substance designed to inhibit a protein called Type I Insulin-Like Growth Factor Receptor (IGF-1R), which can be found on cancer cells and can promote cancer growth.
- Conditions
- Brain Stem Neoplasms, Glioma, Pinealoma
- Trial name
- NCT01182883
- Testing
- IMC-A12, Temsirolimus
- Sponsor
- National Cancer Institute (NCI)
Glioblastoma
Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102
This research study involves an investigational product: Ad-RTS-hIL-12 given with veledimex for production of human IL-12. IL-12 is a protein that can improve the body's natural response to disease by enhancing the ability of the…
- Trial name
- NCT03679754
- Testing
- Ad-RTS-hIL-12, veledimex
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Alaunos Therapeutics
Glioblastoma Multiforme
Glioblastoma Multiforme (GBM) Locoregional Agent Survival Study - Anti-tenascin Radiolabeled Antibody Therapy
The current study will investigate whether the addition of Neuradiab to surgery, radiation and adjuvant chemotherapy (temozolomide) will improve the survival of patients with glioblastoma and whether the drug regimen is safe.
- Trial name
- Glass-Art (NCT00615186)
- Testing
- Neuradiab + Radiotherapy + Temozolomide, Radiation Therapy + Temozolomide
- Volunteers
- 9 people
- Sponsor
- Bradmer Pharmaceuticals Inc.
Low Grade Gliomas, Craniopharyngioma
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
Brain tumours are the commonest solid tumours in children and the second most common neoplasms overall in this patient population. Radiotherapy plays an important part in the management in a majority of these tumours.
- Conditions
- Low Grade Gliomas, Craniopharyngioma, Ependymomas, Meningiomas
- Trial name
- SCRT (NCT00517959)
- Testing
- Stereotactic Conformal radiotherapy, Conventional radiotherapy
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Hospital
Gliomas
Chronic Convection Enhanced Delivery of Topotecan
The primary goal of this study is to establish, for the first time, safety of prolonged intracerebral convection enhanced delivery of chemotherapy in patients with recurrent high grade glioma (HGG).
- Trial name
- NCT03154996
- Testing
- Topotecan, Gadolinium, Synchromed II infusion pumps
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
This phase II trial is studying how well vorinostat works in treating patients with progressive or recurrent glioblastoma multiforme.
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
- Trial name
- NCT00238303
- Testing
- vorinostat, conventional surgery
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Cancer Institute (NCI)
EphA2 Positive Malignant Glioma, CAR-T Cell Immunotherapy
CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
The purpose of this study is to evaluate the safety and effectiveness of CAR-T cell immunotherapy in treating with EphA2 positive malignant glioma patients.
- Trial name
- NCT02575261
- Testing
- CAR-T cell immunotherapy
- Where
- China
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Glioblastoma, Glioma
Radiomics for Prediction of Survival in GBM
Radiomics, the extraction of large amounts of quantitative image features to convert medical images into minable data, is an in-development field that intends to provide accurate risk stratification of oncologic patients.
- Conditions
- Glioblastoma, Glioma, Astrocytoma
- Trial name
- Radiomics (NCT02666066)
- Where
- Netherlands
- Volunteers
- 289 people
- Sponsor
- Maastricht Radiation Oncology
Glioblastoma
A Phase II Clinical Study to Evaluate the Efficacy and Safety of Flazoparib Combined With Temozolomide After the Completion of Standard Concurrent Chemoradiotherapy (CCRT) in Newly Diagnosed Glioblastoma
A Phase II clinical study is planned to evaluate the efficacy and safety of fluzoparib combined with temozolomide in newly diagnosed glioblastoma patients after completing standard concurrent chemoradiotherapy (CCRT), explore the…
- Trial name
- NCT07047066
- Testing
- Fluzoparib with Temozolomide
- Volunteers
- 30 people
- Sponsor
- Tongji Hospital
Adult-Onset Glioma
Genetic Epidemiology of Adult Onset Glioma
To establish a clinic based case control study for examination of potential risk factors for primary adult brain tumors.
- Trial name
- NCT00283569
- Testing
- Mouth Swab, Toe Nail Clippings, Questionnaires
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kentuckiana Cancer Institute
Glial Tumor
Sophrology Treatment for Patients With Glial Tumours Requiring Speech Therapy
Patients with brain tumours experience a loss of independence, which may occur suddenly or gradually. Communication with the patient may be rapidly impaired, due to impaired alertness, language and/or neurocognitive disorders.
- Trial name
- SOPHNEURO (NCT05189366)
- Testing
- Sophrology, Speech therapy
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Institut Cancerologie de l'Ouest
Glioblastoma, CNS Disease
Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma
Phase I: Primary Objectives: -To define the maximum tolerated dose (MTD) of dasatinib (Sprycel) with radiotherapy (RT) and 6 weeks of concomitant temozolomide (TMZ) administered at 75 mg/m^2/day in patients with newly-diagnosed…
- Conditions
- Glioblastoma, CNS Disease, Brain Diseases
- Trial name
- NCT00895960
- Testing
- Dasatinib, RT (Radiotherapy), TMZ (Temozolomide)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer.
- Conditions
- Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor, Central Nervous System Germ Cell Tumor, Choroid Plexus Carcinoma
- Trial name
- NCT04521946
- Testing
- Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center