Clinical trials: Global Surgery
Tourniquet Hypertension
Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery
Knee pain is very common, and more people are having minor knee surgeries done through a small camera (arthroscopy), often as outpatients.
- Trial name
- torniquet (NCT06936410)
- Testing
- Lidocaine 2% Injectable Solution, Dexmedetomidine HCL Injection
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Cairo University
Inferior Vena Cava, Collapsibility Index
Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia
This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general…
- Conditions
- Inferior Vena Cava, Collapsibility Index, Caval Aorta Index, Induction
- Trial name
- NCT07399093
- Testing
- Inferior vena cava collapsibility index, Caval Aorta Index
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Medication Adherence, Antibiotic Resistance, Microbial
7-VINCut Antibiotic Stewardship Intervention to Decrease Duration of Antibiotic Treatment and Carbapenem Use in Surgery
Antimicrobial resistance (AMR) is one of the top ten public health threats facing humanity. The misuse and overuse of antibiotics has been identified as a major factor in the development of drug-resistant pathogens, and 30% of…
- Conditions
- Medication Adherence, Antibiotic Resistance, Microbial, Medication Errors and Other Product Use Errors and Issues
- Trial name
- 7_VINCUT (NCT05813821)
- Testing
- Antimicrobial stewardship in surgery
- Where
- Spain
- Volunteers
- 32,499 people
- Sponsor
- Hospital de Granollers
Type 2 Diabetes
Linagliptin Inpatient Trial
This study is a prospective, randomized, open label trial to compare the safety and efficacy of linagliptin (an oral anti diabetic medication) given orally once daily to an insulin regimen of glargine once daily plus rapid-acting…
- Trial name
- NCT02004366
- Testing
- Linagliptin, Basal Bolus, Linagliptin + 50% Glargine dose on discharge
- Where
- 5 sites in United States
- Volunteers
- 295 people
- Sponsor
- Emory University
Pain, Stress
Evaluation Of The Analgesia Nociception Index vs. Surgical Pleth Index Under General And Regional Anaesthesia
There is a lack of sufficient analgesia monitoring apart from surrogate parameters. The analgesia nociception index (ANI) shall be evaluated under general and regional anaesthesia.
- Conditions
- Pain, Stress, Monitoring
- Trial name
- NCT02744573
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Postoperative Nausea and Vomiting
Aprepitant PO vs Ondansetron IV for Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) persists as one of the more common complications of surgery. Although rarely life-threatening, it is the postoperative outcome that is most unfavorable to patients, even more undesirable…
- Trial name
- NCT00699894
- Testing
- aprepitant 40 mg, ondansetron 4 mg
- Where
- United States
- Sponsor
- Northwell Health
Postoperative Cognitive Dysfunction
Modafinil to Prevent Postoperative Cognitive Decline
Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The…
- Trial name
- NCT03914118
- Testing
- Preoperative modafinil + postoperative modafinil
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Laparoscopic Surgery
Laparoscopic Skills Acquisition Using an AI-enhanced Game-based Simulation Tool Compared With a Laparoscopic Simulator Box Trainer
The goal of this clinical trial is to learn whether an AI-enhanced, game-based laparoscopic simulation tool can improve laparoscopic skills training and help increase surgical capacity in surgical trainees and other healthcare…
- Trial name
- CAMELs-RCT (NCT07276022)
- Testing
- AI-enhanced game-based simulation tool (Laptitude), Laparoscopic simulator box trainer (SurgTrac)
- Where
- 3 sites in Guatemala, India and 1 more
- Volunteers
- 157 people
- Sponsor
- University of Edinburgh
Anesthesiology, General Surgery
The Effect of Enhanced Recovery After Surgery (ERAS) in Gastric Cancer Surgery
The investigators aimed to clarify the clinical relevance of the ERAS protocol by evaluating the perioperative course in patients undergoing laparoscopic gastric cancer surgery.
- Trial name
- NCT06209983
- Testing
- ERAS, Conventional care
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Taiwan University Hospital
Post Operative Pain, Bradycardia
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
Abdominal surgeries are major surgical procedures that are performed at any teaching hospital. Pain control is major concern in the intra-operative as well as post-operative period in these patients.
- Conditions
- Post Operative Pain, Bradycardia, Hypotension, Nausea
- Trial name
- NCT06531603
- Testing
- bupivacaine wound infilteration, Bupivacaine plus dexmedetomidine wound infilteration
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahiwal medical college sahiwal
Ventilator Lung
Airway Pressure Changes Using Esophageal Balloon Catheter (OBC) in Laparoscopic Surgery
This is a single centre study. The investigators intend to recruit 20 subjects over 4 months. Patients undergoing laparoscopic abdominal surgery for cholecystectomy, laparoscopic gynaecological surgery and laparoscopic urologic…
- Trial name
- NCT03411239
- Testing
- Adult esophageal balloon catheter (obc)
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National University Hospital, Singapore
Burst Suppression, Electroencephalogram
Impact of Interscalene Block Combined With General Anesthesia on Burst Suppression in Shoulder Surgery Patients
This prospective, randomized, double-blind clinical study aimed to investigate the effects of combining general anesthesia with an interscalene brachial plexus block (ISB) on burst suppression ratio (BSR) and…
- Conditions
- Burst Suppression, Electroencephalogram, Interscalene Brachial Plexus Block
- Trial name
- NCT07081672
- Testing
- Ultrasound-guided interscalene brachial plexus block (ISB), General Anesthesia (control group)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Inhalation Anesthesia, Dexmedetomidine
The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
Sevoflurane is a volatile agent easy to control thanks to the Minimum Alveolar Concentration (MAC) allowing its titration for an optimal depth of anesthesia.
- Conditions
- Inhalation Anesthesia, Dexmedetomidine, Sevoflurane, Laparoscopy
- Trial name
- NCT05615194
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Gastric Insufflation, I-gel
Gastric Insufflation Volume Using I-gel Versus Ambu AuraGain in Pediatric Patients Undergoing Elective Orthopedic Operations Under General Anesthesia
Our study aimed to compare the gastric insufflation volume between Ambu AuraGain and i-gel and its relationship with the oropharyngeal sealing pressure and the incidence of postoperative complications in generally anesthetized…
- Conditions
- Gastric Insufflation, I-gel, Ambu AuraGain, Pediatric
- Trial name
- NCT06853756
- Testing
- Ambu Auragain, I-gel
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Temperament, Trauma (Including Fractures)
How Personality Type Affects Pain and the Need for General Anesthesia in Patients Receiving an Arm Nerve Block for Wrist Fracture Surgery
This study looked at whether a person's emotional personality type affects how they experience pain and how well a regional anesthesia technique works during arm surgery.
- Trial name
- NCT07450768
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
General Surgery, Perioperative Complication
Perioperative Impact of Physical Activity on Short- and Long-term Morbidity and Mortality
Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.
- Conditions
- General Surgery, Perioperative Complication, Perioperative Medicine, Physical Inactivity
- Trial name
- PeriopIPA (NCT06678360)
- Where
- Sweden
- Volunteers
- 180,000 people
- Sponsor
- Karolinska Institutet
HoLEP, QoR-40
Effect of Anesthesia Techniques on Quality of Recovery Scores in HOLEP Surgery
The aim of this observational study is to evaluate the effects of different anesthesia techniques on the quality of recovery (QoR) and patient satisfaction in male patients, typically older adults with benign prostatic…
- Conditions
- HoLEP, QoR-40, Anesthesia, General, Anesthesia,Spinal
- Trial name
- NCT07020390
- Testing
- Anesthesia method
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- TC Erciyes University
Postoperative Cognitive Dysfunction
Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery
This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.
- Trial name
- NCT01550159
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Maria José Carvalho Carmona
Preoperative Anxiety
Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery
Preoperative anxiety is a common issue in pediatric anesthesia. Children often experience anxiety and uneasiness due to uncertain outcomes.
- Trial name
- NCT06489327
- Testing
- melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg
- Where
- 2 sites in Egypt, Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Third Molar Extraction
Postoperative Analgesia Following Wisdom Teeth Removal: Ropivacaine Versus Placebo
The main objective of this study is to demonstrate the superiority of local analgesia with ropivacaine versus placebo on postoperative pain during the first 24 hours following bilateral surgery of all four third molars under…
- Trial name
- RopiMol (NCT01541059)
- Testing
- Ropivacaine injection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes