Clinical trials: Global Surgery
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Cardiac Disorder, Hypotension
Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery
Arterial hypotension during general anaesthesia (GA) is a serious event. While hypotension can occur during surgery, it usually occurs following induction of GA (i.e. following the injection of drugs to enable intubation).
- Trial name
- EPITUBE-HEART (NCT05335954)
- Testing
- noradrenaline
- Where
- France
- Volunteers
- 211 people
- Sponsor
- Nantes University Hospital
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified
A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements
This study is a prospective, randomized, double-blind clinical trial evaluating whether intraoperative intravenous lidocaine infusion (IVLI) reduces opioid requirements and improves postoperative pain control in children…
- Conditions
- Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation
- Trial name
- NCT07552766
- Testing
- Lidocaine Infusion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nemours Children's Clinic
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Peripheral Vascular Diseases
General Versus Regional Anaesthesia in Peripheral Arterial Surgery: Incidence of Postoperative Pulmonary Complications.
The study will be designed as a prospective clinical trial. Patients scheduled for lower limb arterial bypass surgery will be randomly allocated for treatment with spinal anesthesia associated with spontaneous ventilation (nasal…
- Trial name
- NCT04566016
- Testing
- Regional anesthesia
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Inguinal Hernia
Task Sharing in InGuinal hErnia Repair Between Surgeons and Non-surgeon Physicians
TIGER is a multicentre, 2-arm, parallel group, assessor blinded, non-inferiority randomised controlled trial with an internal pilot to assess if non-surgeon physicians (NSPs) can effectively perform mesh inguinal hernia repair…
- Trial name
- TIGER (NCT06165133)
- Testing
- Mesh inguinal hernia repair performed by Non-Surgeon Physicians (NSP), Mesh inguinal hernia repair performed by fully trained surgeons
- Volunteers
- 1,782 people
- Sponsor
- University of Birmingham
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Knee Arthroscopy
Chloroprocaine Spinal for Outpatient Knee Surgery
Outpatient knee surgeries with duration of less than one hour pose a challenge to the use of spinal anesthesia given that traditional agents remain in effect for 2-3 hours, thus creating a mismatch between length of surgery and…
- Trial name
- NCT03365752
- Testing
- Chloroprocaine, Mepivacaine, General Anesthetics
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Hospital for Special Surgery, New York
Oncology
Evaluation of Low Flow and Normal Flow Anesthesia Management in Robotic Assisted Laparoscopic Surgeries
Robotic-assisted laparoscopic surgery has many advantages compared to conventional open surgery, such as less postoperative pain, shorter hospital stays, and faster recovery times.
- Trial name
- NCT06430593
- Testing
- low-flow anesthesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Kidney Injury, Cardiac Surgery
LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria: 1.
- Trial name
- NCT05879432
- Testing
- LSALT Peptide
- Where
- 9 sites in Canada, Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Arch Biopartners Inc.
Emergency General Surgery
STRATA: Surgical Treatment Using Robotic Approach in The Acute Abdomen
Robotic surgery in the UK is now widely used in elective procedures based on evidence that it can improve outcomes, with improved vision and precision for the surgeon resulting in better results and greater rates of minimally…
- Trial name
- STRATA (NCT07850401)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Portsmouth Hospitals NHS Trust
General Anesthesia, Cervical Plexus Block
EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY
The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and…
- Conditions
- General Anesthesia, Cervical Plexus Block, Thyroid Surgery
- Trial name
- NCT07592832
- Testing
- General Anesthesia, cervical plexus block
- Volunteers
- 60 people
- Sponsor
- Harran University
Cystoscopes, Baxter Anaesthesia Brand of Desflurane
Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery
This is a single-center, prospective, randomized, double-blind, double-arm trial including 68 subjects scheduled to undergo urological cystoscope surgeries under general anesthesia (GA) with intubation through a laryngeal mask…
- Conditions
- Cystoscopes, Baxter Anaesthesia Brand of Desflurane, Sevoflurane
- Trial name
- NCT01219881
- Testing
- Desflurane, Sevoflurane
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University
General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure
Sugammadex and Time to Extubation in Ophthalmic Surgery
This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.
- Conditions
- General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure, Sugammadex, Neostigmine
- Trial name
- NCT06632067
- Testing
- sugammadex, Neostigmine + Atropine
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- China Medical University Hospital
General Anesthesia
Comparison of Refraction Measurments in Children Under General Anesthesia, With and Without Cycloplegic Drops
Assessment of refraction measurements in children under general anesthesia, with or without cyclopelgic eye-drops
- Trial name
- NCT02459600
- Testing
- instulling cyclopentolate drops in the eye
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Chronic Kidney Diseases, General Anesthesia
Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia
Acute kidney injury (AKI) is one of the most serious and frequent complication of general anesthesia. Patients suffer from chronic kidney diseases (CKD) predispose to develop AKI.
- Trial name
- NCT01251029
- Testing
- N-acetylcysteine, Siran (N-acetylcysteine)
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Anesthesia for Elective Surgery Patients
A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery
The study is being conducted to evaluate the efficacy and safety of remimazolam tosilate compared to propofol for general anesthesia during elective surgery.
- Trial name
- NCT03921775
- Testing
- Remimazolam Tosilate, Propofol
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Early Feeding
Length of Stay Between Early Versus Delayed Oral Postoperative Feeding
Length of stay between early versus delayed oral postoperative feeding after gynecologic surgery under General Anesthesia: Randomized Controlled Trial, single center The goal of this Randomized Controlled Trial is to compare…
- Trial name
- LOS (NCT05955495)
- Testing
- Food
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
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