Clinical trials: Global Surgery
Rectal Adenocarcinoma, Non Metastatic
A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
A phase II, single-center, non-profit, interventional study on patients affected by rectal adenocarcinoma. Patients will be stratified into three groups based on pre-treatment clinical stage.
- Trial name
- INTERPRETE (NCT06952101)
- Testing
- Sparing Approach, experimental chemoradiotherapy, Standard Chemotherapy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Postoperative Atelectasis
Supine vs Prone Position and Atelectasis Assessed by Lung Ultrasound
Atelectasis frequently develops during and after general anesthesia due to factors such as anesthesia-induced diaphragmatic dysfunction, reduced functional residual capacity, altered ventilation-perfusion matching, and surgical…
- Trial name
- LUS-ATELEC (NCT07320092)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Elderly, Epidural Anesthesia
Anesthesia-analgesia Methods and Postoperative Delirium
Postoperative delirium is a common complication in elderly patients after surgery. Its occurrence is associated with worse outcomes. The pathophysiology of delirium remains poorly understood.
- Conditions
- Elderly, Epidural Anesthesia, General Anesthesia, Major Surgery
- Trial name
- NCT01661907
- Testing
- Combined Epi-GA/PCEA, GA/PCIA
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Peking University First Hospital
Aneurysm Cerebral
Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery
Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries.
- Trial name
- DACA (NCT03355534)
- Testing
- Intravenous dexmedetomidine, nasal dexmedetomidine, intravenous saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhihong LU
Maxillofacial Injuries
Ultrasound Guided Trigeminal Nerve Block in Maxillofacial Surgeries
This study aims to evaluate the perioperative analgesic effect of USG Trigeminal Nerve Block in adult patients undergoing maxillofacial surgery.
- Trial name
- NCT05567497
- Testing
- trigeminal nerve block
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Suez Canal University
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Open Angle Glaucoma, Ocular Hypertension
MINIject Global Long-Term Follow-up Study
The study will assess the long-term (up to 5 years) safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a MINIject glaucoma implant.
- Trial name
- STAR-GLOBAL (NCT04524416)
- Testing
- Minimally invasive glaucoma surgery (MIGS)
- Where
- 9 sites in Colombia, France and 4 more
- Volunteers
- 116 people
- Sponsor
- iSTAR Medical
Post-induction Hypotension
Management of Post-Induction Hypotension in Emergency Abdominal Surgery
The goal of this clinical trial is to compare the efficacy of two vasopressors (norepinephrine vs. ephedrine) in treating hypotension in adult patients (aged 18+, ASA I-III) undergoing general anesthesia for abdominal surgical…
- Trial name
- NCT07259655
- Testing
- Ephedrine (6 mg boluses), Norepinephrine (10 µg boluses)
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Hopital Charles Nicolle
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
General Anesthesia, Elective Laparoscopic Cholecystectomy
The Effect of Positive End-Expiratory Pressure Levels on Perfusion Index and Neurocognitive Functions in Geriatric Patients
With the increasing geriatric population, age-related physiological changes and common comorbidities increase the risk of surgical and anesthesia-related complications in this patient group.
- Trial name
- NCT07505550
- Testing
- PEEP levels
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ankara City Hospital Bilkent
Outpatients General Surgery Virtual Clinic
Can A Virtual Clinic Review Replace A Surgical Clinic Visit After Discharge?
To assess if a virtual out patient clinic via a telephone review was an acceptable and safe alternative to a clinic attendance for a broad range of general surgical patients discharged following a hospital admission.
- Trial name
- NCT03067220
- Testing
- Virtual outpatient clinic appointment, Standard outpatient clinic appointment
- Where
- Ireland
- Volunteers
- 209 people
- Sponsor
- Connolly Hospital Blanchardstown
Total Fluid Volume Decreased
Preoperative Ultrasound Guided Evaluation of SVC-CI and IVC -CI as Predictors of Hypotension After Induction of Anaesthesia in Major Onco-surgery
Patients undergoing major Oncosurgeries are fluid deficit due to preoperative fasting , inadequate intake due to disease hence prone to development of hypotension after induction of general anaesthesia owing to vasodilatory…
- Trial name
- SVC IVC CI (NCT05548920)
- Testing
- Ultrasound guided Superior Vena Cava Collapsibility Index, Inferior Vena Cava Collapsibility Index
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
General Surgery
Comparison of Apnea Tolerance in Two Positions of Patients With BMI 30-40
The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apnea time (TAT) after induction of general anesthesia in patients with a body mass index (BMI) of 30-40.
- Trial name
- NCT03056820
- Testing
- 25° head-up position, 55° head-up position
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Kansas Medical Center
Optic Nerve Sheath
The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD)…
- Trial name
- NCT02003768
- Testing
- Propofol, Desflurane
- Sponsor
- Yonsei University
Seizures
Revisiting Survey Investigating Why Patients Are Not Receiving Home Anti-convulsant Medication Prior to Surgery/or Procedure Involving General Anesthesia
Children with seizure disorder face unique challenges during the perioperative period. Fasting, sleep-deprivation, and missed doses of medications while patients are required to have nothing per mouth (NPO) are a few factors that…
- Trial name
- NCT01897974
- Testing
- Survey
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vidya Raman
Laparoscopic Cholecystectomy Surgery
Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia
Laparoscopic cholecystectomy (LC) is considered the standard treatment for gallbladder disease.1 Compared to open cholecystectomy, LC is the preferred treatment approach because it is associated with less surgical trauma, shorter…
- Trial name
- NCT06838650
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
Surgery, Post Operative Complications
Enhanced Vitals Monitoring After Major Surgery Trial
The aim of this clinical trial is to examine the feasibility of an enhanced vital sign monitoring solution in-hospital and at-home. This study includes adult patients undergoing inpatient major vascular or abdominal surgery.
- Conditions
- Surgery, Post Operative Complications, Quality of Recovery, General Surgery
- Trial name
- NCT06584825
- Testing
- Enhanced Vitals Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- University of British Columbia
Major Surgery Under General Anesthesia
The Effects of Ambient Temperature and Forced-air Warming on Intraoperative Core Temperature
The purpose of this study is to determine: 1. the effect of ambient temperature on the rate of core temperature change from 1 to 3 hours after induction of anesthesia (linear phase of the hypothermia curve) in major operations…
- Trial name
- NCT02715076
- Testing
- Ambient Temperature 19°C, Ambient Temperature 21°C, Ambient Temperature 23°C
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Peking Union Medical College Hospital
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Lung Diseases, Interstitial
NIVATS Versus IGAVATS: a Pilot Trial Addressing Biopsy Quality in Undetermined Interstitial Lung Diseases
The main objective of this study is to compare two independent groups of patients requiring lung biopsy for undetermined interstitial lung disease (ILD) in terms of diagnostic confidence as determined by histologists.
- Trial name
- NIVATS-2 (NCT05722340)
- Testing
- Non-intubated video-assisted thoracic surgery (NIVATS) for lung biopsy, Intubated general anaesthesia video-assisted thoracic surgery (IGAVATS) for lung biopsy
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
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