Clinical trials: Global Surgery
General Anesthesia
A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery
Investigators hypothesized that the surgical condition will be improved with the use of sugammadex in patients undergoing laryngeal microsurgery.
- Trial name
- NCT01980069
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Acute Kidney Injury, Major Surgery Under General Anesthesia
Risk Factors of Postoperative Acute Kidney Injury and Mortality Among Hospitalized Patients Undergoing Major Surgery
The goal of this retrospective observational study is to learn about the intervenable risk factors of postoperative acute kidney injury (AKI) and in-hospital mortality among adult patients undergoing major surgery.
- Conditions
- Acute Kidney Injury, Major Surgery Under General Anesthesia, Mortality, Postoperative Complication
- Trial name
- NCT07136194
- Where
- China
- Volunteers
- 21,533 people
- Sponsor
- Peking University First Hospital
Wound Infection, Breast Neoplasms
Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine
The development of surgical site infections (SSI) in clean-contaminated surgery is regarded as being preventable. Known to be effective in the prevention of surgical site infection are the adequate sterilization of the surgical…
- Trial name
- NCT02479347
- Testing
- Chlorhexidine, Povidone-Iodine
- Where
- Italy
- Volunteers
- 2,158 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Emergence Agitation, General Anesthesia
Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery
Emergence agitation (EA) is a common complication during recovery from sevoflurane anesthesia, particularly after nasal surgery.
- Conditions
- Emergence Agitation, General Anesthesia, Nasal Surgical Procedures
- Trial name
- NCT07740655
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Jeju National University School of Medicine
Induction of General Anaesthesia
A Phase IIa Study Investigating the Tolerance, Efficacy and Safety of HSK3486
This is a Phase IIa, open-label, propofol-controlled ,dose-escalation, multi-center Study to evaluate the tolerance, efficacy and safety of HSK3486 for induction of general anesthesia in elective surgery patients.This study is…
- Trial name
- NCT03698617
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Gingival Recessions, Generalized
Surgical Treatment for Gingival Recessions After Orthodontic Treatment
Modification of the periodontal soft tissue phenotype and coverage of exposed root surfaces in patients who have undergone orthodontic treatment.
- Trial name
- NCT07763808
- Testing
- Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft
- Where
- Azerbaijan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors
Emergencies
COVID-19 Pandemic and General Surgery Emergencies
A retrospective analysis of emergency general surgical admissions during the first six months of the pandemic (from March 11 to September 11, 2020) and the same period in 2019, will be conducted.
- Trial name
- NCT04686708
- Testing
- Emergency general surgical admissions
- Where
- Turkey (Türkiye)
- Volunteers
- 750 people
- Sponsor
- Gulhane Training and Research Hospital
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Surgery, Bariatric Surgery Candidate
Magnetic System in Bariatric and General Surgery
Magnetic devices have been successfully used in bariatric surgery. To the date the only reported use of the magnet was for liver retraction.
- Trial name
- NCT04944810
- Testing
- Magnetic Gastric Bypass, Magnetic Sleeve Gastrectomy, Revisional Bariatric Surgery
- Where
- Venezuela
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Unidad Internacional de Cirugia Bariatrica y Metabolica
Outpatients, General Surgery
Comparing the Effects of Levobupivacaine and Bupivacaine in Saddle Spinal Anesthesia
İn this study; it was aimed to investigate the effects of equipotent doses of hyperbaric bupivacaine and hyperbaric levobupivacaine in outpatient anorectal surgery under saddle block.
- Conditions
- Outpatients, General Surgery, Anorectal Disorder, Anesthesia
- Trial name
- NCT04245774
- Testing
- Levobupivacaine (as Levobupivacaine Hydrochloride) 75 Mg/10 mL Solution for Injection Ampoule, Bupivacaine/Dextrose
- Volunteers
- 60 people
- Sponsor
- Gazi University
Emergency Abdominal Surgery, Mechanical Ventilation
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery
The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at…
- Conditions
- Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
- Trial name
- IMPROVE-2 (NCT03987789)
- Testing
- Driving-pressure-guided group, Low PEEP
- Where
- 28 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Clermont-Ferrand
Competency in General Endoscopic Surgical Procedures
Trial Evaluating Endoscopy Competence Among Gastroenterology Trainees in the Era of the Next Accreditation System.
Hypothesis: ACE (The Assessment in Competency in Endoscopy Tool) tool for colonoscopy and EGD (Esophagogastroduodenoscopy) allows for reliable standardized learning curves, competency benchmarks, and creation of a centralized…
- Trial name
- EnCompAS (NCT02891304)
- Testing
- Quarterly Feedback
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Procedural Pain
Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain
Propofol is a commonly used intravenous anesthetic agent, but its administration is frequently associated with injection pain, causing patient discomfort and agitation.
- Trial name
- NCT07422558
- Testing
- Nalbuphine, Lidocaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Residual Curarization
Residual Curarization and Its Incidence at Tracheal Extubation in China
This study will assess the residual neuromuscular blockade (NMB) Train-Of-Four (TOF) ratios at tracheal extubation when anesthesiologists have determined that full recovery of neuromuscular function has occurred using standard…
- Trial name
- RECITE-China (NCT01871064)
- Testing
- TOF-Watch SX® Monitoring of NMB
- Where
- 32 sites in China
- Volunteers
- 1,571 people
- Sponsor
- Xinmin Wu
Magnesium Sulfate, Postoperative Pain
Opioid Sparing General Venous Anesthesia With Magnesium Sulfate
Magnesium sulfate has been shown to be useful in many situations in medicine, such as eclampsia prevention and treatment, pulmonary hypertension, arterial pressure, asthma, cardiac arrhythmias and pheochromocytoma.
- Conditions
- Magnesium Sulfate, Postoperative Pain, Opioid Use
- Trial name
- NCT04005599
- Testing
- Remifentanil group, Magnesium sulfate group
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Airway Management, Tracheal Extubation
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery
Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.
- Conditions
- Airway Management, Tracheal Extubation, Postoperative Respiratory Complications, Postoperative Hypoxemia
- Trial name
- ExPress (NCT04381949)
- Testing
- positive pressure extubation
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Mechanical Ventilation Complication, Surgery
a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
The investigators designed a protocol for a Bayesian unplanned posthoc analysis using the pooled dataset from three large randomized clinical trials.
- Conditions
- Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Postoperative Complications
- Trial name
- NCT05886387
- Testing
- High PEEP + Recruitment maneuvers, Standard PEEP. Low positive end-expriatory pressure
- Where
- 4 sites in Brazil, Italy and 2 more
- Volunteers
- 3,836 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Adult Patient Undergoing Elective Surgery With General Anesthesia and Needs Nasogastric Tube Placement
Nasogastric Tube Placement on Intubated Patient: Two-Finger Method vs Reverse Sellick's Maneuver
The study aimed to compare the efficacy between nasogastric tube placement using Two-Finger Method and Reverse Sellick's Maneuver
- Trial name
- NCT03134287
- Testing
- two-finger method, reverse sellick's method
- Where
- Indonesia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cholelithiasis
Fundus-First Laparoscopic Cholecystectomy in Difficult Gallbladders: A Safe Alternative Technique
This retrospective cross-sectional study evaluated the safety and effectiveness of the fundus-first laparoscopic cholecystectomy (FFLC) technique in patients with difficult gallbladders.
- Trial name
- NCT07113704
- Testing
- Conventional Laparoscopic Cholecystectomy, Fundus-First Laparoscopic Cholecystectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- KANAN ISMAYILZADA, MD
Bariatric Surgery, Anesthesia, General
Predictors of Anesthesia Complications in Patients Undergoing Bariatric Surgery
This study aims to identify factors that can predict complications related to anesthesia in patients undergoing weight-loss surgery.
- Conditions
- Bariatric Surgery, Anesthesia, General, Postoperative Complications, Obesity
- Trial name
- NCT06981793
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Centre Hospitalier de Gonesse
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