Clinical trials: Global Surgery
Benign Tumor of Thyroid, Hyperparathyroidism
Bilateral Superficial Cervical Plexus Block in Thyroid/Parathyroid Surgery
To compare efficacy and safety between bilateral superficial cervical plexus block combined with intravenous sedation (RA group) and general anesthesia (GA group) for thyroid and parathyroid operations.
- Trial name
- NCT04051099
- Testing
- Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml), Dexmedetomidine plus propofol infusion, Local infiltraion analgesia
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Thoracic Cancer
Use of a New Stapling Device in General Thoracic Surgery
The goal of this study was to test the safety and efficacy of this stapler in our general thoracic surgery practice.
- Trial name
- NCT05143541
- Testing
- AEON Endostapler
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Lexington Medical Inc.
Cardiac Disorder, Hypotension
Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery
Arterial hypotension during general anaesthesia (GA) is a serious event. While hypotension can occur during surgery, it usually occurs following induction of GA (i.e. following the injection of drugs to enable intubation).
- Trial name
- EPITUBE-HEART (NCT05335954)
- Testing
- noradrenaline
- Where
- France
- Volunteers
- 211 people
- Sponsor
- Nantes University Hospital
Perioperative Pain
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
This explorative post hoc analysis included patients randomized in the DEX-2-TKA trial (NCT03506789) who were operated under general anesthesia with remifentanil and propofol.
- Trial name
- NCT05002361
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 94 people
- Sponsor
- Naestved Hospital
Endoscopic Sinus Surgery, Heart Rate
Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.
The study aims to compare the effect of addition of verapamil and Bisoprolol to general anasthesia aimed reduction in heart rate and blood loss during endoscopic sinus surgery.
- Conditions
- Endoscopic Sinus Surgery, Heart Rate, Blood Loss
- Trial name
- NCT04356196
- Testing
- Verapamil, Bisoprolol
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anxiety, Postoperative Pain
Sublingual Melatonin for Anxiety and Pain in Elective Gynecologic Surgery
This prospective randomized controlled study aims to evaluate the anxiolytic effect of preoperative sublingual melatonin and its impact on postoperative pain scores when administered in two different doses to female patients…
- Conditions
- Anxiety, Postoperative Pain, Anesthesia
- Trial name
- NCT06997263
- Testing
- Melatonin 3 mg Sublingual, Melatonin 6 mg Sublingual
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Benha University
General Anesthetic, Electroencephalogram
General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature.
- Trial name
- NCT05210764
- Testing
- propofol, sevoflurane, S-ketamine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Peking University First Hospital
General Surgery
Serum Neurofilament Light (NFL) in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp)
Experimental studies have shown that inhalational anesthetics may be neurotoxic by for example causing amyloid beta deposition. Otherwise a pre-clinical study reported an increase in tau phosphorylation with the use of propofol.
- Trial name
- NCT04500236
- Testing
- General anesthesia, Hypno-analgesia
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
General Anesthesia, Laparotomy
Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and…
- Conditions
- General Anesthesia, Laparotomy, Inflammation
- Trial name
- PRO-Ketamine (NCT04462094)
- Testing
- Ketamine 0.3 mg/kg at end-of-surgery, Ketamine 0.3 mg/kg at anesthesia induction
- Where
- Indonesia
- Volunteers
- 68 people
- Sponsor
- Udayana University
General Anesthesia, Intraoperative Monitoring
Analysis of Breath Sounds During Surgery
This study aims to analyze breath sounds during surgery by using electronic stethoscope sensors attached to patients under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Monitoring, Respiratory Sounds
- Trial name
- BREATHSOUND (NCT07280546)
- Testing
- Electronic stethoscope monitoring
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anesthesia, General
A Study to Assess Indices of SNAP vs VISTA on Surgical Patients Undergoing General Anesthesia
Establish the range of index values for the SNAP II corresponding to each anesthetic state studied.
- Trial name
- Precision GA (NCT00829803)
- Testing
- SNAP monitor; Bispectral Index Monitor (BIS Monitor)
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stryker Instruments
Negative-Pressure Wound Therapy
Negative Pressure Wound Therapy vs Standard Care Dressing
A comparison between the efficacy of negative pressure wound therapy and the efficacy of standard care dressing
- Trial name
- Prevena (NCT03566641)
- Testing
- Negative pressure wound therapy, standard care dressing
- Where
- United States
- Sponsor
- University of Toledo Health Science Campus
Surgery, Anesthesia
A Study of the Effect of Arterial Carbon Dioxide Tension on the Recovery of Spontaneous Respiration
The investigators data reveal an important new observation regarding the recovery of breathing during emergence from general anesthesia: respiration resumes as a prolonged abdominal expiration event.
- Trial name
- RIP03 (NCT01733446)
- Testing
- Continuation of High Frequency Jet Ventilation (HFJV)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Anesthesia
Automated Administration of Fluids Guided by Dynamic Parameters and Cardiac Output During General Anesthesia
The main objective of this study is to demonstrate that the LIR (Learning Intravenous Resuscitator) Closed-Loop Fluid Administration System (hereafter the "LIR system"), a new device for the automated administration of…
- Trial name
- Closed Loop (NCT02138942)
- Testing
- Learning Intravenous Resuscitator (LIR) system
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pediatric Surgical Procedures Requiring Endotracheal Intubation Under General Anesthesia
Comparison of Optimal Endotracheal Tube Depth Using Four Different Formulas in Children Aged 1-4 Years and Verification With Fiberoptic Bronchoscopy
. The optimal position of the endotracheal tube (ETT) within the trachea is the middle third portion, distal to the vocal cords.
- Trial name
- NCT06937840
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara University
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Interventional Radiology, Surgery
Dynamic Estimation of Cardiac Output in the Operating Room
During major surgery, it is recommended to monitor invasive arterial blood pressure and cardiac output (CO) during hemodynamic interventions (fluid challenge or vasopressors).
- Conditions
- Interventional Radiology, Surgery, General Anesthesia, Organ Failure
- Trial name
- TRIPLEFLOW (NCT04926220)
- Testing
- Trans-esophageal Doppler monitoring, MostCareUP Haemodynamic Monitor, Argos Cardiac Output (CO) Monitor
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
General Anesthesia
A Study Comparing Remimazolam Tosilate and Propofol for Intravenous General Anaesthesia in Operations
The purpose of this study is to find out the optimal dose for Remimazolam Tosilate as an intravenous general anaesthetic drug in operations and to determine its efficacy and safety profile comparing to propofol.
- Trial name
- NCT02406872
- Testing
- Remimazolam Tosilate, Propofol
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Post-operative Nausea and Vomiting
Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting
The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.
- Trial name
- NCT03297021
- Testing
- Ondansetron 4 MG, Ondansetron 8mg
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Incidence Conversion to General Anesthesia, Interleukin-6, Total Tramadol Consumption and Pain Score After Surgery
Erector Spinae Plane Block and Spinal Anesthesia for Supine Percutaneous Nephrolithotomy
This study aimed to compare the Effectiveness of Erector Spinae plane block to Spinal as a surgical anesthesia and analgesia in Percutaneous Nephrolithotomy patient
- Trial name
- NCT04947072
- Testing
- Erector Spinae Plane Block, Spinal anesthesia
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Indonesia
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