Clinical trials: Global Surgery
Trauma, General Anaesthetic Drug Overdose
Modulation of General Anesthesia Using Entropy and Surgical Pleth Index
The critically ill polytrauma patient is one of the most complex cases with regard to the optimization of the intensive care, anesthesia, as well as postoperative management.
- Trial name
- ESPTR (NCT03095430)
- Testing
- Monitoring
- Volunteers
- 72 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Anaesthesia, General, Anesthesia, Intravenous
Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing…
- Conditions
- Anaesthesia, General, Anesthesia, Intravenous, Ventilation
- Trial name
- NCT02706431
- Testing
- Hyperventilation
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
Surgical Wound Infection
Determining the Worldwide Epidemiology of Surgical Site Infections After Gastrointestinal Surgery
Surgical site infection (SSI) is the most common complication following major gastrointestinal surgery, affecting between 25-40% of patients.
- Trial name
- GlobalSurg 2 (NCT02662231)
- Testing
- Emergency, or elective gastrointestinal resection
- Where
- 2 sites in United Kingdom
- Volunteers
- 12,539 people
- Sponsor
- University of Edinburgh
General Anesthetic
HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery
This multicenter, randomized, double-blinded, propofol-controlled Phase 3b study enrolls pediatric subjects aged 3-17 years undergoing elective surgery with endotracheal intubation.
- Trial name
- NCT07510945
- Testing
- HSK3486, propofol
- Volunteers
- 400 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Surgical Complications From General Anesthesia
The Comparison of Two Different Methods of Partial Inflation of Cuff for Facile Insertion of Laryngeal Mask Airway in Pediatric Patients
Partial cuff inflation before insertion is generally used for laryngeal mask airway insertion in children. However, it is not proven how much the cuff should be inflated.
- Trial name
- NCT01435239
- Testing
- The cuff inflation by the resting volume, The cuff inflation by the maximum volume
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
Epidural Anesthesia, Infection
The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery
Sixty neonates and infants will be enrolled and randomised into two groups of n=30 each . For their surgical procedures, one group general (GA) anaesthesia the second group will receive a combined general and epidural anaesthesia…
- Conditions
- Epidural Anesthesia, Infection, Infant, Newborn, Diseases
- Trial name
- NCT03056261
- Testing
- Combined general and epidural, General anaesthesia
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center
Other Peripheral Nerve Disease
Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery
Several reports have compared the duration of action of levobupivacaine and ropivacaine as local anesthetic. The most widely used method for sensory function evaluation is though means of a pinprick test.
- Trial name
- NCT02691442
- Testing
- Ropivacaine 0.75%, Levobupivacaine 0.5%, Levobupivacaine 0.5% + epinephrin 1/200000
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Anesthesia, General
Low-Flow Desflurane vs Sevoflurane: Impact on Physiology and Recoveryand Recovery Profiles in Adult ENT Surgery
This randomized, double-blind, controlled clinical trial aims to compare the effects of low-flow sevoflurane and desflurane anesthesia on physiological parameters and recovery profiles in adult patients undergoing ENT surgeries.
- Trial name
- LoFADS (NCT07016308)
- Testing
- Sevoflurane, Desflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Harran University
Chronic Subdural Hematoma, Anesthesia
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for…
- Trial name
- NCT05888389
- Testing
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia
Comparative Study of Ultrasound Guided Combined Interscalene and Supraclavicular Brachial Plexus Block Versus General Anesthesia for Brachioaxillary Surgery in Renal Failure Patient
The aim of this study is to evaluate the efficacy of combined supraclavicular and interscalene brachial plexus block in brachio-axillary surgeries in chronic renal failure as a sole anesthetic technique in comparison to general…
- Trial name
- NCT04050891
- Testing
- combined supraclavicular and interscalene block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dexmedetomidine, Lidocaine 5% Patch
Lidocaine 5% Patch Supplementation to Intra-articular Bupivacaine Dexmedetomidine After Arthroscopic Knee Surgery
Surgery of the knee is a very common procedure which can be very painful and sufficient postoperative pain treatment is often problematic.
- Conditions
- Dexmedetomidine, Lidocaine 5% Patch, Arthroscopic Knee Surgery, Intra-articular
- Trial name
- NCT04322760
- Testing
- Lidocaine 5% patch with Dexmedetomidine Bupivacaine, Dexmedetomidine Bupivacaine
- Volunteers
- 40 people
- Sponsor
- Tanta University
Anesthesia, Obesity
Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients
Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.
- Trial name
- NCT03417518
- Testing
- Desflurane Inhalant Product, Propofol
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Postoperative Pain, Anesthesia
Regional Anesthesia Versus General Anesthesia
Patients undergoing laparoscopic gynecological surgery will receive regional anesthesia or general anesthesia with endotracheal intubation.
- Trial name
- NCT03830086
- Testing
- Midazolam, Sufentanil, Propofol
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Inhalation Anesthesia, Dexmedetomidine
The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
Sevoflurane is a volatile agent easy to control thanks to the Minimum Alveolar Concentration (MAC) allowing its titration for an optimal depth of anesthesia.
- Conditions
- Inhalation Anesthesia, Dexmedetomidine, Sevoflurane, Laparoscopy
- Trial name
- NCT05615194
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
General Laparoscopic Surgeries
Comparison of Laparoscopic Procedures With and Without the Aid of the AutoLap System- a Robotic Camera Holder
The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections, cholecystectomies and anti-reflux/hiatal hernia surgery with the…
- Trial name
- NCT02934542
- Testing
- AutoLap system
- Where
- Netherlands
- Volunteers
- 108 people
- Sponsor
- M.S.T. Medical Surgery Technology LTD.
Organ Protection
The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.
- Trial name
- NCT05502705
- Testing
- Lidocaine, Normal saline (NS)
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Cement Syndrome, Hypotension and Shock
Role of Inferior Vena Cava Dispensability Index in Predicting Hypotension of Cement Syndrome in Hip Replacement Surgery Under General Anaesthesia
The aim of the study is to evaluate ICV distensibility index for predicting the incidence of hypotension following cementation in orthopedic hip replacement surgery in patient undergoing general anaesthesia
- Trial name
- NCT07669376
- Testing
- Ultrasound measurement of IVC
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Efficacy Povidone Soaked Suture in Reducing Surgical Site Infection
Title: Povidone-soaked Sutures Versus Ordinary Sutures for Reducing Surgical Site Infection
To determine efficacy of using 3 minutes povidone-soaked suture in reducing surgical site infection during wound closure in elective surgery.
- Trial name
- NCT05090176
- Testing
- povidone-soaked suture, ordinary suture
- Where
- Malaysia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Surgery, Death
Risk Calculators Validation for Elective Major General Surgery
Nowadays, over 300 million surgical operations take place every year worldwide, which increase at a rate of 33.6% comparing data from 2005 to 2013.
- Trial name
- RCVEMG (NCT04041076)
- Testing
- Major surgical operation
- Where
- Hong Kong
- Volunteers
- 5,000 people
- Sponsor
- Chinese University of Hong Kong
General Surgery, Cancer of Colon
Preoperative High Protein vs Immunodiet in Surgical Cancer Patients
Immunomodulating nutrition is supposed to reduce the number of complications and the legnth of the hospital stay during the postoperative period in patients after major gastrointestinal surgery.
- Trial name
- Preop immuno (NCT03980704)
- Testing
- IMPACT, resource protein
- Where
- Poland
- Volunteers
- 299 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
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