Clinical trials: Global Surgery
Critical Illness, Postoperative Complications
General Surgery Patients at the Intensive Care Unit
Introduction: high-risk surgical patients in the intensive care unit (ICU) are a unique population that has yet to be carefully monitored.
- Trial name
- TraViII (NCT06731296)
- Testing
- Presence of a risk factor
- Where
- 2 sites in Colombia
- Volunteers
- 1,000 people
- Sponsor
- Hospital Departamental de Villavicencio
Mean Arterial Pressure, Heart Rate
The Effects of Two Induction Means on Emergence After General Anesthesia
This study aims to investigate the effects of different methods of administration on emergence period after laryngeal mask anesthesia in elderly patients undergoing transurethral endoscopic operation
- Trial name
- NCT02974712
- Testing
- Fentanyl, Saline
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Hypotension During Surgery
Study on the Safety and Effectiveness of Remimazolam Tosilate for Injection for Short-term Elective Surgery in Adults
Research objective: To explore the safety and dose exploration of Remimazolam Tosilate for Injection for induction and maintenance of general anesthesia in elective short-term surgery in adults.
- Trial name
- NCT04908553
- Testing
- Remimazolam Tosilate for Injection 0.1mg/kg, Remimazolam Tosilate for Injection 0.15mg/kg, Remimazolam Tosilate for Injection 0.2mg/kg
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Tongji Hospital
Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
This is a multicenter, randomized, double-blinded, propofol-controlled, Phase 3 clinical study to evaluate the efficacy and safety of HSK3486 for induction of general anesthesia in adults undergoing elective surgery.
- Trial name
- NCT04711837
- Testing
- HSK3486, Propofol
- Where
- 13 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Periodontitis Generalized
Periodontal Therapy Effect on the Ratio of TNF-α to IL-10 in Periodontis With/Out DM
Periodontitis is a chronic inflammatory disease affecting the periodontium, characterized by irreversible damage to the gingiva, periodontal ligament, and alveolar bone.
- Trial name
- NCT06539039
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Surgical Education
Global Learning: an Orbis Virtual-platform Evaluation Study
Currently, surgical training is often conducted using the traditional "apprentice model", where a trainee observes a qualified surgeon and learns from him/her, and then the surgeon supervises the trainee performing surgery on a…
- Trial name
- GLOVES (NCT04908072)
- Testing
- Orbis-FundamentalVR MSICS Simulator
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Orbis
Cerebral Autoregulation, Near-infrared Spectroscopy
Determination of Blood Pressure Limit of Cerebral Autoregulation During Non-cardiac Surgery in Preterm Infants, Neonates and Term Infants: a Prospective Observational Study Using Near-infrared Spectroscopy Monitoring
This prospective observational study aims to determine the blood pressure range in which cerebral autoregulation is maintained in preterm neonates, preterm infants, term neonates, and term infants undergoing non-cardiac surgery…
- Conditions
- Cerebral Autoregulation, Near-infrared Spectroscopy, Infant, Newborn, General Anesthesia
- Trial name
- NCT07660302
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Phrenic Nerve Paralysis
the Clinicaltrail of the Effection Which of Phrenic Block Using in Non-intubated Video-assisted Thoracoscopic Surgery
Putting 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral…
- Trial name
- NCT03653494
- Testing
- phrenic block, no phrenic block
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shenzhen People's Hospital
Anesthesia Induction
A Trial to Evaluate the Efficacy and Safety of Methoxyetomidate Hydrochloride for Injection (ET-26) for the Induction of General Anesthesia in Elective Surgery Subjects
This is a multicenter, randomized, double-blind, etomidate-controlled phase III clinical trial. The primary objective is to compare the efficacy and safety between ET-26 and etomidate in the induction of general anesthesia in…
- Trial name
- NCT06203431
- Testing
- ET-26, Etomidate Injectable Emulsion
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Surgery With General Anesthesia, Gynecologic Surgical Procedures
COMPARISON OF PLAIN BLOCKS FOR POSTOPERATIVE PAIN MANAGEMENT IN GYNECOLOGICAL ABDOMINAL SURGERIES
This study compares the effects of transversus abdominis plane (TAP) block, quadratus lumborum block (QLB), and erector spinae plane block (ESP) on postoperative morphine consumption, pain scores, patient satisfaction, and side…
- Conditions
- Surgery With General Anesthesia, Gynecologic Surgical Procedures, Plane Block, Postoperative Pain Management
- Trial name
- ESP QLB TAP (NCT07021105)
- Testing
- ESP Plane block, QLB plane block, TAP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Venous Reflux
VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial
Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal™ Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early and Advanced Stage Superficial Venous…
- Trial name
- NCT03820947
- Testing
- VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
- Where
- 32 sites in United States, Australia and 8 more
- Volunteers
- 506 people
- Sponsor
- Medtronic Endovascular
Hernia Repair, Orchiopexy
Postoperative Pain Relief in Children: Comparing Caudal Bupivacaine Alone Versus Bupivacaine With Dexmedetomidine for Infra-Umbilical Surgeries Under General Anesthesia
This study is being done to find out which medicine combination provides better pain relief after surgery in children. Children who are having surgery below the belly button (called infra-umbilical surgery) will receive general…
- Conditions
- Hernia Repair, Orchiopexy, Hypospadias
- Trial name
- NCT07121764
- Testing
- Bupivacaine %0.25 (isobaric), Dexmedetomidine & Bupivacaine.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Teaching Hospital
Acute Kidney Injury, Cardiac Surgery
LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria: 1.
- Trial name
- NCT05879432
- Testing
- LSALT Peptide
- Where
- 9 sites in Canada, Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Arch Biopartners Inc.
Preoperative Evaluation, Anesthesia
Effects of General Health Risk Factors on Prolonged Hospital Stay
According to the literature, a detailed preoperative anesthesia assessment systematically verifies perioperative risks, provides functional and physiological optimization, improves the patient's condition and the perioperative…
- Conditions
- Preoperative Evaluation, Anesthesia, Day Surgery, Life Style
- Trial name
- NCT06810232
- Testing
- Gastrointestinal endoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 580 people
- Sponsor
- Naime Yalçın
Postoperative Delirium
Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients
POD has been reported to be associated with a large number of risk factors: age as POD occurs in 10% to 61% of those aged 65 or older, dementia, impaired left ventricular function, electrolyte disorder, alcoholism, smoking, high…
- Trial name
- NCT04483596
- Testing
- melatonin effect on the Abbreviated Mental Test
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Hypotension During Surgery
Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy
This study is a randomized controlled trial designed to investigate the effects of two anesthetics, remimazolam and propofol, on intraoperative hemodynamics in patients undergoing laparoscopic liver resection.
- Trial name
- NCT06714669
- Testing
- propofol, Remimazolam
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Sun Yat-sen University
Appendicitis
A Comparison of Appendicectomy Outcomes in Children Between Paediatric and General Surgical Centres in Scotland
Introduction Appendicectomy (or appendectomy in US usage) is the single most commonly performed emergency surgical operation performed on British children.
- Trial name
- NCT02047786
- Where
- United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- University of Edinburgh
Anxiety; Generalized, Breast Diseases
Randomized, Placebo-Controlled Study: Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Patients
The study is designed to see if lavender aroma therapy reduces pre-operative anxiety in breast surgery patients.
- Conditions
- Anxiety; Generalized, Breast Diseases, Surgery
- Trial name
- NCT01837966
- Testing
- Lavender oil
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- NYU Langone Health
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