Clinical trials: Global Surgery
Hyperoxemia, Intraoperative Oxygen Therapy
Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position
This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients…
- Conditions
- Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation
- Trial name
- ORI-BCP (NCT07404267)
- Testing
- ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Morbid Obesity
Two Different Regimens of Bemiparin as a Thromboprophylaxis in Morbidly Obese Surgical Patients
Morbid obesity, is known to be associated with a high risk of VTE and, unfortunately, fixed doses of anticoagulant regimens may not provide optimal VTE prophylaxis in these patients especially after surgery.
- Trial name
- NCT05569681
- Testing
- Bemiparin 3500, Bemiparin 5000 IU
- Where
- Iraq
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and…
- Trial name
- NCT00777465
- Where
- Brazil
- Volunteers
- 2,804 people
- Sponsor
- Hospital de Base
Elderly, Epidural Anesthesia
Anesthesia-analgesia Methods and Postoperative Delirium
Postoperative delirium is a common complication in elderly patients after surgery. Its occurrence is associated with worse outcomes. The pathophysiology of delirium remains poorly understood.
- Conditions
- Elderly, Epidural Anesthesia, General Anesthesia, Major Surgery
- Trial name
- NCT01661907
- Testing
- Combined Epi-GA/PCEA, GA/PCIA
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Peking University First Hospital
General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure
Sugammadex and Time to Extubation in Ophthalmic Surgery
This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.
- Conditions
- General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure, Sugammadex, Neostigmine
- Trial name
- NCT06632067
- Testing
- sugammadex, Neostigmine + Atropine
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- China Medical University Hospital
Chronic Disease
Impact of Mulstidisciplinary Medication Assessment Review in Surgery Departments
The presence of a clinical pharmacist (for their pharmacological expertise) and a general practitioner (for their somatic expertise) in surgery departments would contribute to improve the management of medications in elderly…
- Trial name
- CHIROPMEV (NCT03827031)
- Testing
- Mutlidisciplinary medication Review (MMR), Mutlidisciplinary medication Review (MMR) with community pharmacist follow-up
- Where
- 4 sites in France
- Volunteers
- 297 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Surgery, Noise Exposure
The Effect of a Reduced Noise Environment on Induction and Emergence Behavior in Children Undergoing General Anesthesia
This project will investigate whether reduction in ambient light and elimination of noise on induction of anesthesia alters anxiety (modified Yale Preoperative Anxiety Scale or mYPAS) or compliance (induction compliance checklist…
- Trial name
- NCT03504553
- Testing
- Noise reduction
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Joshua Uffman
Emergency Service, Hospital, General Surgery
The Impact of the Covid-19 Outbreak on Emergency Room Attendances of Surgical Patients
Since December 2019, when the novel coronavirus disease (Covid-19) spread throughout the world, data have been needed on the effects of the pandemic on various aspects of healthcare systems.
- Trial name
- NCT04338672
- Testing
- COVID-19 Pandemic
- Where
- Israel
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration in Patients With Regional Anesthesia
General anesthesia is a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Anesthesia Recovery Period
- Trial name
- GORA (NCT06040307)
- Testing
- SPI (Surgical Pleth Index)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Complications, Surgery
Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery (GENERATOR)
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high Positive End Expiratory Pressure (PEEP) strategy…
- Trial name
- GENERATOR (NCT06101511)
- Testing
- Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs
- Where
- Netherlands
- Volunteers
- 1,806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Respiratory Complication
Driving Pressure During General Anesthesia for Open Abdominal Surgery
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high PEEP strategy, aiming at avoiding an increase in…
- Trial name
- DESIGNATION (NCT03884543)
- Testing
- Individualized high PEEP strategy
- Where
- 22 sites in Germany, Italy and 1 more
- Volunteers
- 1,468 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Nerve Block, General Anesthesia
Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
The purpose of this study is to determine if there is a difference in patient outcomes with general anesthesia versus spinal anesthesia when given in addition to popliteal and adductor canal nerve blocks for foot and ankle…
- Conditions
- Nerve Block, General Anesthesia, Spinal Anesthesia, Pain
- Trial name
- LMA vs Spinal (NCT02996591)
- Testing
- 25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block, 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block, Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Hospital for Special Surgery, New York
Damage Control for Perforated Diverticulitis
Trial on Damage Control Surgery for Perforated Diverticulitis With Generalized Peritonitis
Damage control surgery (DCS) with abdominal negative pressure therap (NPT) and delayed anastomosis creation in patients with perforated diverticulitis and generalized peritonitis was established at our Institution in 2006 and has…
- Trial name
- Damage Control (NCT04034407)
- Testing
- Damage control surgery
- Volunteers
- 22 people
- Sponsor
- Medical University Innsbruck
Surgery, Pain
Postoperative Music for Orbital Decompression
The purpose of this study is to evaluate the effect of music to the postoperative pain and discomfort after orbital decompression.
- Conditions
- Surgery, Pain, Musth
- Trial name
- NCT04933201
- Testing
- Music, Routine perioperative treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Generalized Aggressive Periodontitis, Aggressive Periodontitis
Alternative Antibiotic Regime in the Treatment of GAgP
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized…
- Trial name
- NCT02223702
- Testing
- Amoxicillin, Metronidazole, Moxifloxacin
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Complications of Surgical and Medical Care: General Terms
Comparison of Loop-tip Cook Medical® Wire Versus Traditional Endoscopic Technique
The purpose of this study is to test a new guide-wire (loop-tip wire) with a loop in the tip for the prevention of PEP and biliary tree access, in post-ERCP pancreatitis in high-risk patients.
- Trial name
- loop (NCT02232451)
- Testing
- ERCP with loop tip wire, ERCP for cannulation
- Volunteers
- 320 people
- Sponsor
- Azienda Ospedaliera San Paolo
The Study Was Aimed to Assessing the Clinical Profile of Acute Abdomen and Their Frequency According to Age and Sex
A Retrospective Case Series Study for Acute Abdomen in General Surgery Ward
The acute abdomen is a clinical situation in which an acute an change in the condition of intra-abdominal organ, commonly attached to inflammation or infection need urgent and correct diagnosis .
- Trial name
- NCT05088200
- Testing
- surgery
- Where
- Afghanistan
- Volunteers
- 118 people
- Sponsor
- Ahmadullah Danish
General Surgery
Evaluation of Apnea Tolerance in Bariatric Patients Following Rapid-sequence Induction of Anesthesia
The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apneic time (TAT) in bariatric patients scheduled for laparoscopic adjustable gastric band surgery…
- Trial name
- NCT03056807
- Testing
- 25° head-up position, 55° head-up position
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Kansas Medical Center
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