Clinical trials: Global Surgery
Post Operative Pain
Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
Patients undergoing breast cancer surgery experience persistent pain after surgery and subsequent development of chronic pain. Parecoxib or paracetamol has been reported to reduce postoperative pain in mastectomy.
- Trial name
- NCT05757388
- Testing
- Parecoxib + paracetamol, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Major Abdominal/GI Surgery
Effects of Nutritional Preconditioning on the Patient's Outcomes After Surgery
Malnutrition is a serious problem in patients undergoing major surgeries and has a direct association with increased morbidity, mortality, length of stay (LOS), increased readmissions and cost of care.
- Trial name
- NCT03692507
- Testing
- HMB, Protein and HMB, ERAS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Emergency Surgery, Surgical Site Infections
Irrisept in Emergency General Surgery Patients
This is a single institution, randomized study conducted to determine if irrigation with Irrisept in emergency general surgery patients results in lower surgical site infections compared to normal saline irrigation.
- Trial name
- NCT07048899
- Testing
- Chlorhexidine, Normal Saline
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center at Tyler
Anesthesiology, Pediatrics
A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor
Study hypothesis: The Cardiotronic ICON non-invasive cardiac output monitor gives accurate information when placed on a patient's Right or Left side.
- Conditions
- Anesthesiology, Pediatrics, General Surgery, Orthopedics
- Trial name
- NCT01678066
- Testing
- Bilateral cardiac output
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
WALANT, Radius Fracture Distal
Prospective Observational Study Comparing GA and WALANT in Distal Radius Fracture Plating Surgery
The wide-awake local anesthesia no tourniquet (WALANT) has been widely used in the field of hand surgery in recent years. This surgical method has progressed to open reduction and internal fixation of distal radial fracture and…
- Trial name
- NCT04549441
- Testing
- Distal radius fracture plating surgery
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University
Cerebral Autoregulation, Near-infrared Spectroscopy
Determination of Blood Pressure Limit of Cerebral Autoregulation During Non-cardiac Surgery in Preterm Infants, Neonates and Term Infants: a Prospective Observational Study Using Near-infrared Spectroscopy Monitoring
This prospective observational study aims to determine the blood pressure range in which cerebral autoregulation is maintained in preterm neonates, preterm infants, term neonates, and term infants undergoing non-cardiac surgery…
- Conditions
- Cerebral Autoregulation, Near-infrared Spectroscopy, Infant, Newborn, General Anesthesia
- Trial name
- NCT07660302
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Perioperative Analgesia
Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries
This study will evaluate the effect of adding dexmedetomidine to bupivacaine compared to ketamine in the caudal block on perioperative analgesia in patients undergoing lumbosacral surgeries under general anesthesia.
- Trial name
- NCT07573969
- Testing
- Group C (plain bupivacaine (0.125%)), Group D (plain bupivacaine (0.125%) + 2μg/kg dexmedetomidine), Group K (plain bupivacaine (0.125%) + 1mg/kg ketamine)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Interventional Radiology, Orthopedic Surgery
Change in Brain Perfusion During Induction of General Anesthesia
Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality.
- Trial name
- CERVO2 (NCT04288869)
- Testing
- Continuous monitoring of arterial blood pressure, Transcranial Doppler, Bispectral Index (BIS)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Thoracic Cancer
Use of a New Stapling Device in General Thoracic Surgery
The goal of this study was to test the safety and efficacy of this stapler in our general thoracic surgery practice.
- Trial name
- NCT05143541
- Testing
- AEON Endostapler
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Lexington Medical Inc.
Cerebral Perfusion, Cerebral Oxygenation
Evaluation of Cerebral Oxygenation During Orthopedic Surgeries Performed in the Beach Chair Position Under General Anesthesia
The goal of this observational study is to determine the correlation between cerebral oxygenation values measured by near-infrared spectroscopy (NIRS) and other routine monitoring parameters in patients placed in the semi-sitting…
- Conditions
- Cerebral Perfusion, Cerebral Oxygenation, Hemodynamic Monitoring, Semi-sitting Position
- Trial name
- NCT07270341
- Testing
- Near-Infrared Spectroscopy (NIRS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Akdeniz University
Intra-abdominal Surgery, Anesthesia
Open Lung Protective Extubation Following General Anesthesia
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development.
- Conditions
- Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury
- Trial name
- OLEXT-3 (NCT06296173)
- Testing
- Protective "open-lung" extubation, Conventional extubation
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Surgery--Complications, Emergencies
Morbimortality in Major Urgent General Surgery in the Geriatric Patient.
Retrospective observational cohort study of geriatric patients operated of urgent major general surgery in our centre during 2018. Our principal goals are: 1.
- Trial name
- NCT04725968
- Testing
- Urgent major general surgery
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Extravasation, Vein Injury
Color Doppler and Peripheral Venous Catheters
Objective: To evaluate color Doppler flow ultrasound compared to standard clinical techniques, to detect the correct position of peripheral intravenous catheters in adult surgical patients.
- Trial name
- NCT03889678
- Testing
- Color flow doppler
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University
Surgical Site Infection
Skin Staples vs Polypropylene in Elective Laparotomy
Surgical site infection (SSI) is one of the most common postoperative complications following elective laparotomy and contributes significantly to patient morbidity, prolonged hospital stay, and increased healthcare costs.
- Trial name
- NCT07781878
- Testing
- Skin staples, Polypropylene skin suture
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
General Surgery, Cancer of Colon
Preoperative High Protein vs Immunodiet in Surgical Cancer Patients
Immunomodulating nutrition is supposed to reduce the number of complications and the legnth of the hospital stay during the postoperative period in patients after major gastrointestinal surgery.
- Trial name
- Preop immuno (NCT03980704)
- Testing
- IMPACT, resource protein
- Where
- Poland
- Volunteers
- 299 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
Laparoscopy, Anesthesia, Intravenous
The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery
The objective is to evaluate the efficacy and safety of BT-KTM-I(Esketamine Hydrochloride Injection produced by Chengdu Brilliant Pharmaceutical Co., Ltd.) for general anesthesia, using the Originator drug Ketanest®S(Esketamine…
- Trial name
- NCT06092684
- Testing
- BT-KTM-I, Ketanest®S
- Where
- 12 sites in China
- Volunteers
- 358 people
- Sponsor
- Chengdu Brilliant Pharmaceutical Co., Ltd.
Abdominal Cancer Surgeries
Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries.
________________________________________ Background : Major abdominal cancer surgery is among the most invasive procedures, often associated with extensive tissue damage, severe postoperative pain, and delayed recovery.
- Trial name
- NCT07214714
- Testing
- Fentanyl (IV), Dexmedetomidine
- Volunteers
- 70 people
- Sponsor
- Assiut University
Meniscus Tear, Femoral Nerve Block
FNB in Meniscal Tear Under GA
The investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for meniscal tear under general anesthesia
- Trial name
- NCT06045884
- Testing
- Sono-guided injection, Ropivacaine injection, Saline injection
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Tuberculosis, Spinal
The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis
The purpose of this study is to determine the better preoperative anti-tuberculosis treatment period of patients with spinal tuberculosis.
- Trial name
- NCT02477852
- Testing
- Isoniazid, Rifampicin, Ethambutol
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Chest Hospital
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