Clinical trials: Global Surgery
Acute Kidney Injury, Cardiac Surgery
LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria: 1.
- Trial name
- NCT05879432
- Testing
- LSALT Peptide
- Where
- 9 sites in Canada, Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Arch Biopartners Inc.
Postoperative Agitation, Emergence Agitation
Minimal- Versus High-Flow Sevoflurane and Emergence Agitation in Pediatric Surgery
This study aims to evaluate the effects of minimal-flow sevoflurane compared with high-flow sevoflurane during maintenance of general anesthesia on postoperative emergence agitation in opioid-free pediatric infraumbilical…
- Trial name
- NCT07635004
- Testing
- caudal block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Breast Cancer Female
GENe EXpression After Regional or General ANesthesia in Patients Undergoing Breast Cancer Surgery
Breast cancer is the most commonly diagnosed cancer in females and the second leading cause of death from cancer in women. It was estimated that 2 million new cases have occurred in 2018 worldwide 1.
- Trial name
- GENEXAN (NCT03779685)
- Testing
- General anesthesia, Regional anesthesia
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Anesthesia, Pain
Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia
The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach.
- Conditions
- Anesthesia, Pain, Surgery
- Trial name
- SPIDER (NCT03218306)
- Testing
- Surgical Pleth Index, Clinical guidance
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- University of Cagliari
Surgery, Colorectal Cancer
Postoperative Electrical Muscle Stimulation Two
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity.
- Conditions
- Surgery, Colorectal Cancer, Muscle Atrophy, Cancer Gi
- Trial name
- POEMS2 (NCT06964438)
- Testing
- Neuromuscular Electrical Stimulation, Protein supplement drink
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Shouldersurgery
Assessing Cerebral Blood Flow Autoregulation During Surgery in the Head-up Position
Neurological injury after elective shoulder surgery in the beach chair position is thought to result from cerebral hypoperfusion and should therefore be preventable by appropriate hemodynamic monitoring and management.
- Trial name
- NCT01225185
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Breast Cancer
Paravertebral Block, an Adjunct to General Anaesthesia for Breast Surgery?
Aim is to study if a paravertebral block as an adjunct to general anesthesia is a suitable technique for extended, one sided, breast surgery.
- Trial name
- NCT00547989
- Testing
- standard anaesthesia (bupivacaine), additional pvb (ropivacaine) and elastomeric disposable infusion pump, additional pvb (ropivacaine)
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Maastricht University Medical Center
General Surgery, Orthopedic Procedures
Implementing Virtual Reality in the Operating Room
"Recently, virtual reality has become more accessible thanks to the use of smaller, more comfortable and easier-to-use devices. Its use in operating theatres is growing.
- Trial name
- IRVABO (NCT06333639)
- Testing
- orthopaedic surgery, orthopaedic surgery and fitted with a virtual reality headset
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anterior Cervical Discectomy and Fusion (ACDF) Surgery
Comparison of Postoperative QoR-15 Scores Between Sevoflurane and Remimazolam
The purpose of the study is to compare the quality of recovery (QoR)-15 scores according to the use of maintenance anesthetics in the cervical spine surgery.
- Trial name
- NCT05019222
- Testing
- Sevoflurane based inhalation anesthesia, Remimazolam based total intravenous anesthesia
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Elective Surgeries, General Anesthesia
Validation of the PRST Score Against Bispectral Index
The goal of this randomized controlled trial is to evaluate whether the PRST (Evans) score is a valid method for monitoring the depth of general anesthesia in adult surgical patients.
- Conditions
- Elective Surgeries, General Anesthesia, BIS
- Trial name
- NCT07590388
- Testing
- PRST Monitoring, PRST + BIS Monitoring
- Where
- Indonesia
- Volunteers
- 183 people
- Sponsor
- Gadjah Mada University
Major Depressive Disorder, MDD
Operation of Brain Stimulation Equipment Under Remote Viewing Effectiveness Registry
The goal of this observational study is to record and analyze factors putatively affecting the clinical outcomes among patients undergoing transcranial magnetic stimulation (TMS) treatment for major depressive disorder (MDD) or…
- Conditions
- Major Depressive Disorder, MDD, Generalized Anxiety Disorder, GAD
- Trial name
- OBSERVER (NCT06512324)
- Testing
- Ampa One TMS System
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Biomedical Discoveries and Neuroscientific Foundations LLC
Oxygen Saturation, Respiratory Distress Syndrome
Imputation of Arterial Oxygen Partial Pressures Using Pulse Oximetry
This study aims to validate existing PaO₂ prediction equations (Rice, Pandharipande, Gadrey, Hill, Severinghaus-Ellis) by comparing predicted PaO₂ values with measured values.
- Conditions
- Oxygen Saturation, Respiratory Distress Syndrome, Anesthesia, General
- Trial name
- NCT06283914
- Where
- Lebanon
- Volunteers
- 300 people
- Sponsor
- American University of Beirut Medical Center
Ovarian Neoplasm
Impact of Specific Monitoring of Intraoperative Analgesia Under General Anesthesia on Chronic Pain After Ovarian Cancer Surgery
This is a single-center, randomized, phase II, non-comparative, single-blind clinical study that will determine whether morphine reduction through intraoperative monitoring by ANI (Analgesia Nociception Index) significantly…
- Trial name
- MONIALC (NCT04906187)
- Testing
- Arm A : intraoperative ANI monitoring of nociception, Arm B : no specific monitoring of nociception
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Institut Bergonié
Surgery and covid19
The ALIGHIERI Survey: an Italian Overview of Global Impact of tHe COVID-19 pandemIc on General surgERy practIce
Introduction The present survey aimed to provide a comprehensive overview of the Italian scenario concerning general surgery during the first wave COVID-19 outbreak and evaluate the experiences, trends, attitudes, and possible…
- Trial name
- ALIGHIERI (NCT04824664)
- Testing
- survey
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Associazione Chirurghi Ospedalieri Italiani
Type 2 Diabetes, Inpatient Hyperglycemia
Basal Bolus Insulin Versus SSRI in Type 2 Diabetes Undergoing General Surgery
High blood glucose levels in surgical patients with diabetes are associated with increased risk of medical complications and death.
- Trial name
- RABBIT 2-SX (NCT00596687)
- Testing
- Insulin glargine, Regular insulin, Insulin glulisine
- Where
- 2 sites in United States
- Volunteers
- 234 people
- Sponsor
- Emory University
Oral Surgical Procedures, Surgery, Oral
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Anxious Patients
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Conditions
- Oral Surgical Procedures, Surgery, Oral, Dental Anxiety, Surgery
- Trial name
- NCT00355693
- Testing
- Pump for propofol delivery
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Competency in General Endoscopic Surgical Procedures
Trial Evaluating Endoscopy Competence Among Gastroenterology Trainees in the Era of the Next Accreditation System.
Hypothesis: ACE (The Assessment in Competency in Endoscopy Tool) tool for colonoscopy and EGD (Esophagogastroduodenoscopy) allows for reliable standardized learning curves, competency benchmarks, and creation of a centralized…
- Trial name
- EnCompAS (NCT02891304)
- Testing
- Quarterly Feedback
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Oncology
Evaluation of Low Flow and Normal Flow Anesthesia Management in Robotic Assisted Laparoscopic Surgeries
Robotic-assisted laparoscopic surgery has many advantages compared to conventional open surgery, such as less postoperative pain, shorter hospital stays, and faster recovery times.
- Trial name
- NCT06430593
- Testing
- low-flow anesthesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pregnancy, Cesarean Delivery
Pharmacogenetics of Remifentanil in Patients With Hypertension Undergoing Cesarean Delivery Under General Anesthesia
Caesarean delivery under general anaesthesia (GA) carries nowadays still 25% risk of insufficient depth of anaesthesia in a time before the fetus delivery. The reason is the lack of opioid administration.
- Conditions
- Pregnancy, Cesarean Delivery, General Anesthesia
- Trial name
- NCT01550640
- Testing
- Remifentanil
- Where
- Czechia
- Volunteers
- 149 people
- Sponsor
- Charles University, Czech Republic
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