Clinical trials: Global Surgery
Analgesia
Efficacy and Safety of HSK21542 in Inducing Postoperative Analgesia in Undergoing Elective Laparoscopic Surgery
This is a multicenter, randomized, double-blind, placebo-controlled, two-stage phase II clinical study. The main objective is to evaluate the efficacy and safety of HSK21542 injection and explore the recommended dose and…
- Trial name
- NCT04424251
- Testing
- Experimental: stage I：HSK21542 0.4 μg/kg, Experimental: stage I：HSK21542 1 μg/kg, Experimental: stage I：HSK21542 0.5μg/kg
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Inguinal Hernia
Task Sharing in InGuinal hErnia Repair Between Surgeons and Non-surgeon Physicians
TIGER is a multicentre, 2-arm, parallel group, assessor blinded, non-inferiority randomised controlled trial with an internal pilot to assess if non-surgeon physicians (NSPs) can effectively perform mesh inguinal hernia repair…
- Trial name
- TIGER (NCT06165133)
- Testing
- Mesh inguinal hernia repair performed by Non-Surgeon Physicians (NSP), Mesh inguinal hernia repair performed by fully trained surgeons
- Volunteers
- 1,782 people
- Sponsor
- University of Birmingham
Orchiopexy
Comparison of Analgesic Efficacy of Fascia Transversalis Plan Block and Caudal Epidural Block in Pediatric Patients Undergoing Orchiopexy
Orchiopexy is a surgery with a high frequency in the pediatric population. The use of regional anesthesia techniques has become widespread and its importance has increased in order to provide more effective and prolonged…
- Trial name
- NCT07006844
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
General Anesthesia
Impact of Virtual Reality (VR) and Music Intervention
The purpose of this study is as follows.The purpose of this study is as follows. First, it aims to examine the differences in anxiety, depression, and sleep quality based on the inclusion of a music intervention during relaxation…
- Trial name
- NCT06728163
- Testing
- written education group, VR educational material + breathing relaxation with verbal instruction, VR educational material + breathing relaxation with music intervention
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Emergency Abdominal Surgery
Intermediate Care - Effect on Mortality Following Emergency Abdominal Surgery
The objective of this trial is to evaluate postoperative intermediate care versus ward care in patients who have undergone emergency abdominal surgery with a perioperative Acute Physiology and Chronic Health Evaluation (APACHE)…
- Trial name
- InCare (NCT01209663)
- Testing
- Postoperative Intermediate Care
- Where
- 7 sites in Denmark
- Volunteers
- 286 people
- Sponsor
- Copenhagen University Hospital at Herlev
Anesthesia
High Flow Oxygen in Patients Undergoing Surgery Under General Anesthesia
Preoxygenation remains an important determinant of morbidity and mortality in anesthesia despite advances in mask ventilation and difficult intubation management. 1.
- Trial name
- OPTIFLOW (NCT03554863)
- Testing
- Nasal High Flow Oxygen, Facial Mask
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- CMC Ambroise Paré
Surgical Procedures, Operative
Evaluation of Efficacy and Accuracy of a Cordless Ultrasonic Dissection System
The purpose of this study is to test the efficacy of a new cordless ultrasonic dissection system.
- Trial name
- SCUD (NCT01929928)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Wake Forest University Health Sciences
General Surgery
Elder-friendly Approaches to the Surgical Environment (EASE) Study
The aim of this study is to examine the impact implementing an elder-friendly surgical unit has on post-operative complications, mortality and quality of life for patients ≥ 65 years old who have undergone emergency surgical care.
- Trial name
- EASE (NCT02233153)
- Testing
- Elder-Friendly Surgical Unit
- Where
- 2 sites in Canada
- Volunteers
- 723 people
- Sponsor
- University of Alberta
General Surgery
Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
SVV is clinically affected by a variety of factors, such as abdominal pressure, body position, tidal volume, type and temperature of liquid treatment, etc. There are few reports on the effects of drugs on SVV.
- Trial name
- NCT03497351
- Testing
- Nicardipine, Urapidil
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Chinese PLA General Hospital
Anaesthesia, General, Anesthesia, Intravenous
Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing…
- Conditions
- Anaesthesia, General, Anesthesia, Intravenous, Ventilation
- Trial name
- NCT02706431
- Testing
- Hyperventilation
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
Organ Protection
The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.
- Trial name
- NCT05502705
- Testing
- Lidocaine, Normal saline (NS)
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia, Blood Pressure
Norepinephrine Prevent Post-induction Hypotension in High-risk Patients
The investigators aimed to investigate the effects of continuous infusion of norepinephrine before and after general anesthesia induction on the occurrence of post-induction hypotension.
- Conditions
- Anesthesia, Blood Pressure, Norepinephrine
- Trial name
- NCT06028256
- Testing
- Norepinephrine Hydrochloride
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Elderly Patients, Laparoscopic Surgery
Transnasal Microstream EtCO2 Reduces Hypoxemia During Emergence in Aged Post-Abdomen Surgery
This prospective, randomized controlled study aims to investigate whether transnasal microstream end-tidal carbon dioxide (EtCO₂) monitoring in the post-anesthesia care unit (PACU) reduces the incidence of postoperative hypoxemia…
- Conditions
- Elderly Patients, Laparoscopic Surgery, Postoperative Hypoxemia, Capnography
- Trial name
- NCT07652385
- Testing
- EtCO₂ Monitoring, Routine Monitoring
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Jianbo Wu
Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary)
AI-ECG for Preoperative Cardiovascular Risk Stratification Before General Surgery
This randomized controlled trial evaluates whether an artificial intelligence-enhanced electrocardiography (AI-ECG)-based strategy for preoperative cardiovascular risk stratification is noninferior to usual care in patients…
- Conditions
- Perioperative Cardiovascular Risk, Postoperative Complications (Cardiopulmonary), Preoperative Care
- Trial name
- NCT07774689
- Testing
- AI-ECG-based preoperative risk stratification (ECG Buddy)
- Where
- South Korea
- Volunteers
- 3,200 people
- Sponsor
- Seoul National University Bundang Hospital
Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia
The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
- Conditions
- Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia, Block Level, Gastrointestinal Surgery
- Trial name
- NCT02135016
- Testing
- 1% lidocaine, 2% lidocaine, 0.9% normal saline
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
Postoperative Pain, Pain Management
Patients' Perceptions of Postoperative Analgesic Monitoring in Elective General Surgery
This study examines how patients perceive postoperative analgesic monitoring during routine care in elective general surgery. Postoperative pain monitoring is a standard nursing practice, but patients may experience it as either…
- Trial name
- PSAM-SEM (NCT07389330)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Agri Ibrahim Cecen University
General Anesthetic, Electroencephalogram
General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature.
- Trial name
- NCT05210764
- Testing
- propofol, sevoflurane, S-ketamine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Peking University First Hospital
Ankle Sprains, Instability, Joint
The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL
Investigators designed this prospective cohort study to compare the clinical outcomes of modified Broström operation and anatomical reconstruction for the treatment of CLAI and GJL.
- Conditions
- Ankle Sprains, Instability, Joint, Joint Hypermobility
- Trial name
- NCT05196906
- Testing
- Modified Broström operation and anatomic reconstruction operation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Endobronchial Metastases, Bronchoesophageal Fistula
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
This study is a prospective, randomized, controlled trial. In this study, 30 patients who underwent endotracheal tumor resection under rigid bronchoscope or stent placement for acquired tracheoesophageal fistula were selected as…
- Conditions
- Endobronchial Metastases, Bronchoesophageal Fistula, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT05468671
- Testing
- Remimazolam, Propofol, Rocuronium
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Zhejiang Cancer Hospital
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