Clinical trials: Globus Pharyngeus
Parkinson Disease
Continuous Electrical Neuromodulation of the Globus Pallidus Intern in Parkinson's Disease by the Directional Electrode CARTESIA™
Many patients have benefited from the implantation of brain stimulation electrodes for the treatment of various motor signs of Parkinson's disease in the phase of motor fluctuations.
- Trial name
- NEC-Parkinson (NCT05626608)
- Testing
- Classical ring stimulation, Stimulation in directional mode
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Temporal Interference Stimulation, Parkinson's Disease
The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) Targeting the Right Globus Pallidus Internus (GPi) for Motor Symptoms in Patients With PD
To demonstrate that intervention targeting the right globus pallidus internus (GPi) using transcranial temporal interference stimulation can improve motor symptoms in patients with Parkinson's disease.
- Conditions
- Temporal Interference Stimulation, Parkinson's Disease, the Right Globus Pallidus Internus, Motor Symptoms
- Trial name
- NCT06931483
- Testing
- Transcranial temporal interference stimulation (tTIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yanghua Tian
Parkinson's Disease
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
The goal of the second phase of the study is to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's…
- Trial name
- NCT01076452
- Testing
- Bilateral Deep Brain Stimulation
- Where
- 14 sites in United States
- Volunteers
- 299 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease, Dystonia
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation technique capable of targeting both superficial and deep brain areas with high spatial resolution, down to a few cubic millimeters.
- Trial name
- NCT06232629
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Association of Heterotopic Gastric Mucosa of the Cervical Esophagus and Globus Sensations
Prevalence of Gastric Inlet Patches of the Cervical Esophagus.
As known from several observational and retrospective endoscopic studies the prevalence of gastric inlet patches (GIPs) of the cervical esophagus is estimated between 1-10%.
- Trial name
- NCT01056003
- Testing
- Endoscopy
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- Technical University of Munich
Symptomatic Heterotopic Gastric Mucosa
Radiofrequency Ablation in Patients With Large Cervical Heterotopic Gastric Mucosa and Globus Sensation
Symptomatic heterotopic gastric mucosa also known as cervical inlet patch (CIP) may be present in varying shapes and causes symptoms of laryngopharyngeal reflux like globus sensations, hoarseness and chronic cough.
- Trial name
- NCT03023280
- Testing
- Radiofrequency ablation
- Volunteers
- 10 people
- Sponsor
- Dr. Ivan Kristo
Parkinson's Disease
ExAblate Transcranial MRgFUS of the Globus Pallidum for Treatment of Parkinson's Disease
The proposed study will evaluate the safety, and initial efficacy of using the ExAblate Transcranial to create a unilateral lesion in the globus pallidus as an adjunct to PD medications in subjects who are over 30 years of age…
- Trial name
- NCT02263885
- Testing
- ExAblate Transcranial System
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- InSightec
Tourette Syndrome
Observational Database on Deep Brain Stimulation in Tourette Syndrome
Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then…
- Trial name
- POSTSTIC (NCT04449068)
- Testing
- Neurological and neuropsychological Follow-up after deep brain stimulation, EEG recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease
Characterizing the Specificity and Stability of Local Field Potentials in the Globus Pallidus Internus of Patients Undergoing Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation for Parkinson's disease is a well established therapy. Current practice requires tedious adjustment of stimulation settings based on frequent patient assessments.
- Trial name
- NCT02438033
- Testing
- Medtronic Activa PC+S Sensing Deep Brain Stimulator Generator
- Sponsor
- Nader Pouratian
Scoliosis Idiopathic
Globus Reflect Tether - HUD
The purpose of this device is to treat children and adolescents with scoliosis who have growth remaining. In patients with a curvature about the spine, Reflect holds the convexity of the curve in place so that the concavity can…
- Trial name
- NCT06521814
- Testing
- REFLECT scoliosis correction system
- Sponsor
- Medical University of South Carolina
Globus
The Effect of Laryngeal Manual Therapy as a Management of Globus
The purpose of this study is to assess the effect of laryngeal manual therapies in the treatment of globus (sensation of a lump in the throat).
- Trial name
- NCT04436146
- Testing
- laryngeal manual therapies
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- HaEmek Medical Center, Israel
Cervical Dystonia
Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia
Cervical dystonia (CD), also known as spasmodic torticollis, is a type of focal dystonia, mainly manifesting as involuntary head turning or tilting, or holding a twisted posture.
- Trial name
- NCT05715138
- Testing
- GPi-DBS, STN-DBS, GPi-DBS devices
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese PLA General Hospital
Parkinson Disease
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
Evaluate the safety and efficacy of unilateral focused ultrasound pallidotomy using the ExAblate 4000 System in the management of dyskinesia symptoms or motor fluctuations for medication refractory, advanced idiopathic…
- Trial name
- NCT03319485
- Testing
- ExAblate Pallidotomy
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 92 people
- Sponsor
- InSightec
Parkinson Disease
Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus
In the proposed pilot project, MRI data will be prospectively collected to show the feasibility of the segmentation algorithm and the potential relation to final lead positioning.
- Trial name
- NCT03600740
- Testing
- DBS Programming
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Globus Sensation
Comparing Pregabalin and Placebo in Patients With Persistent Globus Sensation
To evaluate the relative merits, safety and effectiveness of pregabalin in globus patients compared with placebo.
- Trial name
- Lyrica (NCT05432843)
- Testing
- Pregabalin
- Where
- 2 sites in Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Deep Brain Stimulation
Unilateral GPi vs Unilateral STN DBS in the Same Patient With PD
The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two main targets in the deep brain stimulation (DBS) treatment for Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Globus Pallidus Interna, Subthalamic Nucleus
- Trial name
- NCT04255719
- Testing
- DBS
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Ruijin Hospital
PD - Parkinson's Disease
Subthalamic Nucleus Versus Globus Pallidal Internus Deep Brain Stimulation for Parkinson Disease
The primary objective of this prospective, multicenter, double-blind, randomized, crossover clinical trial is to evaluate whether Subthalamic Nucleus-Deep Brain Stimulation (STN-DBS) is more effective than Globus Pallidus…
- Trial name
- Superior PD (NCT07250685)
- Testing
- STN-DBS stimulation, GPi-DBS stimulation, STN&GPi-DBS stimulation
- Where
- 8 sites in China
- Volunteers
- 86 people
- Sponsor
- Zhang Jianguo
Globus Sensations in the Throat
Long Term Outcome of Argon Plasma Coagulation of Cervical Heterotopic Gastric Mucosa as an Alternative Treatment for Globus Sensations
APC of gastric inlet patches is successful for the treatment of globus sensations in the throat (Bajbouj et al Gastroenterology 2009; 137:440-4). There is no data for long term efficiency of this treatment.
- Trial name
- ACHAT FU (NCT01574755)
- Volunteers
- 49 people
- Sponsor
- Technical University of Munich
Parkinson Disease, Mild Cognitive Impairment
Simultaneous DBS of the GPi and the NBM in Patients With Parkinson's Disease and Mild Cognitive Impairment
Phase 1 study evaluating the safety of combined bilateral globus pallidus internus (GPi) and nucleus basalis of Meynert (NBM) stimulation in treating levodopa responsive motor symptoms of Parkinsonism and cognitive dysfunction…
- Trial name
- NCT05320523
- Testing
- Deep brain stimulation implantation of a Vercise neurostimulation system in GPi and NBM., GPi stimulation, NBM stimulation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Generalized Dystonia, Segmental Dystonia
Validation of the Implantation of a New Electrode for the Treatment of Dystonia
The main objective of the trial is to study the technical feasibility of the implantation of a new electrode Monocontact deep brain stimulation electrode in dystonia.
- Conditions
- Generalized Dystonia, Segmental Dystonia, Tardive Dystonia
- Trial name
- MONOCONTACT (NCT02509338)
- Testing
- Electrode deep brain stimulation (Monopolar DBS Lead Model 09064-40cm)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Montpellier