Clinical trials: Globus Pharyngeus
Parkinson Disease
Globus Pallidus Stimulation to Treat Insomnia
Researchers are to determine if turning on an additional unilateral DBS (deep brain stimulation) electrode with stimulation to the globus pallidus externa (GPe) region of the brain will improve insomnia (sleep).
- Trial name
- GPS-I (NCT04116996)
- Testing
- DEEP BRAIN STIMULATION
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Gilles de la Tourette Syndrome
Pallidal Stimulation and Gilles de la Tourette Syndrome
The aim of this study is to evaluate the efficacy and safety of bilateral pallidal stimulation in patients with a severe form of Gilles de la Tourette syndrome.
- Trial name
- STIC (NCT00478842)
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Brain Stimulation, Parkinson Disease
Visualization of the STN and GPi for DBS
The purpose of the study is to determine if using SIS System for DBS planning results in less distance between the planned target location and the actual implanted lead location than DBS planning without SIS System.
- Trial name
- VISION (NCT05774041)
- Testing
- SIS System
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Surgical Information Sciences Inc.
Parkinson Disease
Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation
Follow up of patients enrolled in CSP 468, a study of deep brain stimulation treatment for Parkinson's disease
- Trial name
- CSP#468F (NCT01022073)
- Where
- 12 sites in United States
- Volunteers
- 156 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
The goals of this study are to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's disease, and if deep…
- Trial name
- NCT00056563
- Testing
- Bilateral Deep Brain Stimulation, best medical therapy
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease
Asymmetric Targeted DBS for PD With PIGD
The purpose of this study is to compare the effectiveness of the deep brain stimulation of asymmetric targets [subthalamic nucleus (STN) in the right hemisphere while globus pallidus interna (GPi) in the left] versus the…
- Trial name
- ATS-PIGD (NCT05397340)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Effects of Deep Brain Stimulation on Motor, Mood, and Cognitive Symptoms in Parkinson's Disease
The purpose of this trial is to study the mood and cognitive effects of deep brain stimulation in Parkinson's disease.
- Trial name
- NCT00360009
- Testing
- DBS of the STN, DBS of the GPI
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Florida
Parkinson Disease
Deep Brain Stimulation for Parkinson's Disease: the Globus Pallidus Internus Versus Subthalamic Nucleus
This study provides an evaluation of 30 patients in 3 years, from the Unified Health System (SUS) irrespective of region of the country, signed with clinical Parkinson's disease in its intermediate stage and that the drug therapy…
- Trial name
- NCT02647372
- Testing
- Subthalamic nucleus, Globus pallidus
- Volunteers
- 30 people
- Sponsor
- Hospital Sirio-Libanes
Globus Pharyngeus
Bump the Lump - Intervention for the Treatment of Globus Pharyngeus
To develop a standardized speech-language pathology treatment protocol to systematically address Globus pharyngeus (GP) as a proof of concept
- Trial name
- NCT06762444
- Testing
- Speech-language pathologist (SLP) protocol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Dystonia
Pallidal Stimulation in Patients With Post-anoxic and Idiopathic Dystonia
Bilateral pallidal stimulation is effective in the treatment of patients with generalised idiopathic dystonia. The aim of this study is to evaluate the efficacy of bilateral pallidal stimulation in patients with post-anoxic…
- Trial name
- NCT00169338
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Marie-laure Welter
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Dyskinetic Cerebral Palsy Due to Perinatal Hypoxia
Effect of DBS on Quality of Life in Dyskinetic Cerebral Palsy
There are limited therapeutical options for patients with secondary dystonia due to cerebral palsy. Pharmacotherapy is often without effect, or side effects are severe.
- Trial name
- STIM-CP (NCT02097693)
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital of Cologne
Dystonia
Pallidal Stimulation in Patients With Idiopathic Generalised Dystonia
Pallidal stimulation is effective in patients with generalised idiopathic dystonia. The aim of this study is to: 1. evaluate the efficacy and safety of this treatment in patients with idiopathic generalised dystonia, 3 years…
- Trial name
- NCT00169403
- Testing
- Deep brain stimulation
- Where
- France
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Presbylarynx, Aspiration
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders.
- Conditions
- Presbylarynx, Aspiration, Spasmodic Dysphonia, Globus Pharyngeus
- Trial name
- NCT06078527
- Testing
- Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Schizophrenia, Schizophrenia Schizoaffective
Focused Ultrasound Modulation of the Globus Pallidus Interna in Schizophrenia
This is a single-site, phase 2, sham-controlled random-order cross-over pilot trial of PLIFUS targeting the right GPi in individuals with schizophrenia.
- Trial name
- NCT05643196
- Testing
- PLIFUS, MRI
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Tourette's Syndrome
Optimising Anterior Pallidal Deep Brain Stimulation for Tourette's Syndrome
The motor tics associated with Tourette's syndrome may be reduced with deep brain stimulation of the anterior globus pallidus. The best area within this brain region and the best stimulation device settings are currently unknown.
- Trial name
- NCT02112253
- Testing
- Deep brain stimulator ventral electrode up to 2 mA, Deep brain stimulator ventral electrode up to 3 mA, Deep brain stimulator dorsal electrode up to 2 mA
- Where
- Australia
- Sponsor
- The University of Western Australia
Dystonia, Dystonia, Focal
Local Field Potentials in Dystonia
The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS…
- Conditions
- Dystonia, Dystonia, Focal, Dystonia, Primary
- Trial name
- LFP-DYT (NCT07309133)
- Testing
- Deep Brain Stimulation System
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Globus
Treatment in Patients With Globus: Psychoeducation, Anxiolytics or Proton Pump Inhibitors
A randomized controlled trial study is conducted to compare treatment efficacy between psycho-education, anxiolytics drug and proton pump inhibitors in participants who met the criteria of globus.
- Trial name
- NCT03205228
- Testing
- Omeprazole, psychoeducation, Flupentixol +Melitracen
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Parkinson&Amp;#39;s Disease, Freezing of Gait
Understanding Freezing of Gait Using Brain Signals and Virtual Reality
Freezing of gait - the inability to start or continue walking - is a particularly disabling problem in Parkinson's disease that has few treatment options.
- Conditions
- Parkinson&Amp;#39;s Disease, Freezing of Gait, Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
- Trial name
- NCT07092995
- Testing
- VR Freezing Task, Dual Task, External Cueing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, Los Angeles
Parkinson's Disease
Mobile Decision Support System for Nurse Management of Neuromodulation Therapy
The purpose of this study is to test the use of a clinical decision support tool for postoperative care of Parkinson's disease patients who are treated using deep brain stimulation (DBS).
- Trial name
- NCT02474459
- Testing
- iPad-Based Clinical Support Care, Standard Clinical Care
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Utah