Clinical trials: Glucagon
Obesity
Effects of Beta-glucan on Energy Intake and Satiety
The purpose of this study is to address the effect of consuming 4g of soluble fibre beta-glucan at breakfast on satiety and food intake.
- Trial name
- NCT02637388
- Testing
- Oatwell28 Oatwell Original Powder, Control Breakfast
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Healthy Adult Subject
A Relative Bioavailability and Food Effect Study of HDM1002 in Healthy Subjects
The main purpose of this study is to evaluate the effect of formulation on relative bioavailability of HDM1002, and the food effect on pharmacokinetics of HDM1002.
- Trial name
- NCT06608329
- Testing
- HDM1002
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Hyperinsulinism, Hypoglycemia
Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients
The purpose of this study is to determine whether the investigators' new imaging modality (111In-exendin-4) has advantages in detecting insulinomas in comparison to conventional imaging.
- Conditions
- Hyperinsulinism, Hypoglycemia, Insulinoma
- Trial name
- NCT00937079
- Testing
- 111In-exendin-4 imaging
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 1 Diabetes Mellitus
Efficacy of Glucagon In the Prevention of Hypoglycemia During Mild Exercise
The study will consist of two study arms. Each arm will include a 24-96 hour outpatient run-in period prior to their exercise visit wearing the bi-hormonal bionic pancreas.
- Trial name
- NCT03217175
- Testing
- Bihormonal Bionic Pancreas, Insulin Only Bionic Pancreas, Glucagon
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Morbid Obesity
Gut Hormones After Roux-en-Y Gastric Bypass (RYGBP) Plus Gastric Fundus Resection
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is considered a combination of restriction-malabsorption procedure and one of the most common operative procedures implemented.
- Trial name
- NCT01341028
- Testing
- Roux-en-Y gastric bypass (LRYGBP), LRYGBP+gastric fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Glucose, High Blood
Hydration to Optimize Metabolism
This study evaluates hydration (1.5 L of water daily during 1 year) in the lowering of blood glucose concentration in adults with signs of dehydration (elevated levels of the vasopressin marker copeptin and high urine…
- Trial name
- H2O-metabolism (NCT03422848)
- Testing
- Water, general life style advice
- Where
- Sweden
- Volunteers
- 797 people, healthy volunteers welcome
- Sponsor
- Region Skane
Postprandial Hypoglycemia
Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia
It has been proposed that the rapid gastric emptying of carbohydrate containing fluids into the intestine causes hyperglycemia followed by reactive hypoglycemia.
- Trial name
- NCT01162499
- Testing
- Exendin-(9-39), Vehicle
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Diva De Leon
Non-alcoholic Fatty Liver Disease
Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia
The purpose of this study is to examine whether non-alcoholic fatty liver disease (NAFLD) is associated with hepatic glucagon resistance and hyperglucagonemia.
- Trial name
- NCT02337660
- Testing
- Liver biopsy, Pancreatic clamp
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Weight Loss, NASH
Phase 1 Study to Evaluate the Safety and Tolerability of VK2735
This is a Phase 1, randomized, double-blind, placebo-controlled single and multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VK2735 in healthy adults and…
- Trial name
- NCT05203237
- Testing
- VK2735, VK2735 Drug
- Where
- Australia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Viking Therapeutics, Inc.
Wrinkle
Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists
Clinical trial to assess the effect of microdroplet hyaluronic acid filler to the cheek skin (SKINVIVE™, JUVÉDERM®, Irvine, CA) on skin quality in patients undergoing medical weight loss with GLP-1 therapy.
- Trial name
- NCT07221461
- Testing
- Skinvive
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Effect of Glucagon-like Peptide 2 on Gallbladder Motility
Effect of Glucagon-like Peptide 2 on Gallbladder Motility After a Meal in Young, Healthy Male Subjects
The study will investigate the effect of the incretin hormone glucagon-like peptide 2 (GLP-2) on postprandial gallbladder motility in young, healthy, male subjects. The study is double-blinded, randomized and placebo controlled.
- Trial name
- NCT03682172
- Testing
- GLP-2 (1pmol/kg/min), GLP-2 (10pmol/kg/min)
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes
The purpose of this study is to see if giving study drugs before a meal may lower blood sugars after the meal. An improvement in blood sugar control may prevent long-term problems of diabetes.
- Trial name
- T2DM (NCT00950677)
- Testing
- Byetta (exenatide), Symlin (pramlintide)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor College of Medicine
Psoriasis Arthritis
GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis
Background Psoriatic arthritis (PsA) patients are at increased risk of cardiovascular disease. Glucagon-Like Peptide-1 (GLP-1) receptor agonists are cardiovascular protective in diabetics.
- Trial name
- NCT07251556
- Testing
- Semaglutide 0.5 mg, Semaglutide 1.0 mg, Semaglutide 0.25 mg
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Obesity
Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects
The main purpose of this study is to examine the effect of prolonged (72 hour) administration of glucagon compared to placebo on energy expenditure in healthy, non-diabetic, obese subjects.
- Trial name
- GIO B (NCT03139305)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Diabetes, Diabetes Mellitus, Type 2
Effect of Liraglutide on Glucagon Secretion in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to examine the effect of NNC 90-1170 on the hypoglycaemic counterregulation in subjects with type 2 diabetes.
- Trial name
- NCT01509742
- Testing
- liraglutide
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Novo Nordisk A/S
Heart Failure
Effects of Glucagon Like Peptide-1 on Haemodynamic Parameters
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates plasma glucose, and GLP-1 analogues were recently introduced for the treatment of acute myocardial infarction.
- Trial name
- NCT02490176
- Testing
- liraglutide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Obesity
Incretin Physiology and Beta-cell Function Before and After Weight-loss
To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT00625040
- Testing
- Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Chronic Kidney Diseases
Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease
Chronic kidney disease (CKD) is a burden of morbidity and mortality. Increased protein breakdown in skeletal muscle (wasting) and ectopic fat deposition are important determinants of poor clinical outcome in patient with CKD.
- Trial name
- GLIMP (NCT05254418)
- Testing
- dulaglutide injection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes.
- Trial name
- MicroGlucag2 (NCT06854861)
- Testing
- Lyumjev 100 UNT/ML Injectable Solution, Premixed Lyumjev
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- St. Olavs Hospital
Diabetes Mellitus Type 1
A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas
This study will test the hypothesis that a wearable bionic pancreas system that automatically delivers insulin and glucagon can provide superior regulation of glycemia versus usual care for adults with type 1 diabetes.
- Trial name
- NCT02092220
- Testing
- Bionic Pancreas, Insulin pump with or without CGM
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital