Clinical trials: Glucocorticoids
Eosinophilic Esophagitis
Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)
Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, characterized by eosinophilic infiltration and gastrointestinal symptoms.
- Trial name
- FLUTE (NCT03191864)
- Testing
- APT-1011
- Where
- 75 sites in United States, Belgium and 4 more
- Volunteers
- 106 people
- Sponsor
- Adare Pharmaceuticals, Inc.
Postoperative Recovery, PONV
Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems.
- Trial name
- NCT07469332
- Testing
- Saline (0.9% NaCl), TAP Block, moderate dose Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara City Hospital Bilkent
Type 1 AIP
A Trial on the Remission Rates of Type I Autoimmune Pancreatits With High-risk of Recurrence
Autoimmune pancreatitis (AIP) is an autoimmune disease with low incidence rate and involving the pancreas. In China, type I AIP is predominant. Glucocorticoids (GC) have a significant therapeutic effect.
- Trial name
- AIP；MMF (NCT06468709)
- Testing
- Glucocorticoids, Glucocorticoids+MMF
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Ruijin Hospital
Endocrine Disease, Diabetes
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
Background: Metabolic syndrome is a name given to a group of factors that tend to occur together. These risk factors include central obesity (extra weight around the middle of the body) and high blood pressure and blood sugar…
- Trial name
- NCT01419535
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Muscular Dystrophy, Duchenne, Ambulatory Care
Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD)
The aim of this Phase III study was to assess the efficacy of idebenone on pulmonary function, motor function, muscle strength and quality of life in patients with DMD.
- Trial name
- DELOS (NCT01027884)
- Testing
- Idebenone
- Where
- 23 sites in United States, Austria and 8 more
- Volunteers
- 65 people
- Sponsor
- Santhera Pharmaceuticals
Evaluate the Safety and Efficacy of Denosumab in Pediatric Subjects With, Glucocorticoid-induced Osteoporosis
Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis
To evaluate the effect of denosumab on lumbar spine bone mineral density (BMD) Z-score as assessed by dual-energy X-ray absorptiometry (DXA) at 12 months in children 5 to 17 year of age with Glucocorticoid (GC)-induced…
- Trial name
- NCT03164928
- Testing
- Denosumab
- Where
- 38 sites in United States, Australia and 11 more
- Volunteers
- 24 people
- Sponsor
- Amgen
Sudden Sensorineural Hearing Loss (SSNHL)
Acupuncture Therapy for Sudden Sensorineural Hearing Loss
The goal of this multicenter, prospective, randomized controlled trial is to evaluate the efficacy and safety of acupuncture combined with corticosteroid therapy in treating sudden sensorineural hearing loss (SSNHL).
- Trial name
- SSNHL-Acu (NCT07575334)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Takayasu Arteritis
Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis
This is a prospective, double-blinded, single center, randomized clinical trial. It compares the clinical efficacy and safety of thees 2 drugs in the treatment of active Takayasu's arteritis patients.
- Trial name
- TOFGCTAK (NCT05749666)
- Testing
- Tofacitinib 5 MG, Prednisolone
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese SLE Treatment And Research Group
Acute Alcoholic Hepatitis
Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
This study will compare two different treatments of acute alcoholic hepatitis. The current standard of care is treatment with corticosteroids (methylprednisolone).
- Trial name
- NCT01809132
- Testing
- Anakinra, Pentoxifylline, Zinc Sulfate
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Mack Mitchell
Glucocorticosteroid, Diabetes
Diabetes Screening in Patients on Long-Term Glucocorticoid Therapy
Glucocorticoids are widely prescribed in the treatment of many inflammatory, autoimmune or allergic diseases, but also in transplant patients or patients with malignant hematological diseases (leukaemia, lymphoma, myeloma, etc.).
- Trial name
- DIACORT (NCT04258293)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Arthritis, Rheumatoid
Effectiveness of Bazedoxifene for Prevention of Glucocorticoid-induced Bone Loss in RA Patients
The purpose of this study is to study the effectiveness of bazedoxifene in preventing loss of bone mineral density (BMD) and trabecular bone score (TBS), and any fractures in postmenopausal rheumatoid arthritis (RA) patients…
- Trial name
- NCT02602704
- Testing
- Bazedoxifene, Calcium/Vit D
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Hanyang University
Generalized Myasthenia Gravis, gMG
A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab
This is a prospective, multicenter single arm study designed to evaluate the effectiveness and safety of a predefined oral corticosteroids (OCS) tapering schedule to reduce OCS use in adult participants with acetylcholine…
- Trial name
- OCTAGON (NCT07221838)
- Testing
- Oral Corticosteroid Tapering Schedule, Ravulizumab, Prednisone/Prednisolone
- Where
- 12 sites in United States, Germany and 2 more
- Volunteers
- 75 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Adrenal Insufficiency
Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)
This study compares low-dose prednisolone therapy against standard regimens of hydrocortisone therapy for the treatment of adrenal insufficiency (AI).
- Trial name
- PRED-AID (NCT03936517)
- Testing
- Prednisolone, Hydrocortisone
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver
Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC
The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage.
- Trial name
- NCT01608945
- Testing
- Hydrocortisone sodium succinate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Sciatica
Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
The purpose of this study is to determine whether anti-inflammatory drugs or glucocorticoids are effective in the treatment of acute sciatica
- Trial name
- TéAGS (NCT01816334)
- Testing
- methylprednisolone, Ketoprofen, Sodium Chloride
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Pemphigus
European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus
By this study, the investigators want to test if the value of adjuvant pulse glucocorticoid therapy for pemphigus can be determined by comparing an experimental arm (dexamethasone pulse therapy, prednisolone, and azathioprine)…
- Trial name
- NCT00127764
- Testing
- dexamethasone (50mg 1dd6, 3 consecutive days/month)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Rotator Cuff Tears, Rotator Cuff Tendinitis
Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease
The primary objective of this study is to assess the overall safety and general tolerability of extended release triamcinolone acetate (TA-ER/FX006) in patient with rotator cuff disease.
- Conditions
- Rotator Cuff Tears, Rotator Cuff Tendinitis, Rotator Cuff Impingement, Injections
- Trial name
- NCT04094298
- Testing
- FX006 Injection
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwell Health
Nephrotic Syndrome
Steroid Diabetes in Patients With Kidney Disease
If steroid diabetes is not recognized in time, it will cause irreversible damage to the body. Nephropathy patients are more likely to have steroid diabetes ,the incidence rate up to 25%,due to hypoalbuminemia, high-dose hormone…
- Trial name
- NCT06161701
- Testing
- no intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Provincial People's Hospital
Opioid Dependence, Cocaine Dependence
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.
- Trial name
- Goliath (NCT02935101)
- Testing
- Prednisolone
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Prof. Dominique de Quervain, MD
Rheumatoid Arthritis
Monoarticular Corticosteroid Injection Versus Systemic Administration in the Treatment of Rheumatoid Arthritis Patients
The purpose of this study is to compare the efficacy and safety of intra-articular glucocorticoid injection to its systemic use for treatment of knee synovitis in patients with Rheumatoid Arthritis
- Trial name
- NCT00506896
- Testing
- intraarticular injection
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo