Clinical trials: Glucocorticoids
Atopic Dermatitis
Evaluation of the Effectiveness and Safety of Immunosuppressive and Biological Therapy of Atopic Dermatitis in Childhood
This comparative study analyzes the efficacy and safety of treatment of children from 6 years of age suffering from moderate to severe atopic dermatitis using an inhibitor of IL4, IL13 and classical immunosuppressants.
- Trial name
- NCT04895423
- Testing
- Methotrexate therapy, Mycophenolate mofetil therapy, Cyclosporine therapy
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Body Composition, Beneficial
Impact of Exercise on Body Composition in Premature Infants
This research consists of a novel intervention designed to increase physical activity of premature babies in their first year of life. The potential beneficial impact of augmented physical activity on: 1. Body composition 2.
- Trial name
- NCT01386190
- Testing
- Exercise/Social Behavioral
- Where
- United States
- Sponsor
- University of California, Irvine
Chronic Disease, Glucocorticoid Therapy, Response to
Efficacy Study of Recombinant Growth Hormone on Muscle Function in Children Long-term Treated With Glucocorticoid
Children suffering from chronic disease and receiving long-term glucocorticoid therapy suffer over years from severe growth retardation and profoundly altered body composition.
- Conditions
- Chronic Disease, Glucocorticoid Therapy, Response to, Growth Retardation
- Trial name
- NCT00813189
- Testing
- GH treatment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association REMEDE
Hyperglycemia Steroid-induced
Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy
Objective: to determine which regimen results in best glycemic control and safety profile, expressed as glucose values within target range and occurrence of hypoglycemia.
- Trial name
- GluCon-Chemo (NCT02155374)
- Testing
- Sliding scale insulin, Intermediate acting insulin, Dietary advice
- Where
- 3 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Slotervaart Hospital
Osteoarthrosis
Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total knee-arthroplasty (TKA).
- Trial name
- NCT02319343
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polymyalgia Rheumatica
Rituximab Effect on Decreasing glUcoCorticoid Exposition in PolyMyalgia Rheumatica Patients Recently Diagnosed
Polymyalgia rheumatica (PMR) is prevalent among elderly. Untreated, it leads to major reduction in quality of life. Glucocorticoids are the cornerstone of treatment, but have drawbacks, warranting glucocorticoid sparing…
- Trial name
- REDUCE-PMR-1 (NCT05533125)
- Testing
- Rituximab
- Where
- Netherlands
- Volunteers
- 114 people
- Sponsor
- Sint Maartenskliniek
Stress
Physical and Mental Load in the Surgeon Performing Laparoscopic Tasks
The surgeons load during laparoscopic surgery is still unclear. Laparoscopic surgery is more demanding because of the challenge of operating through small scars in the abdominal wall without any tactile feedback depending only on…
- Trial name
- NCT00311285
- Testing
- Electrogram (EMG), heart rate variability (HRV), salivary cortisol, goniometry, inclinometry
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Allergic Bronchopulmonary Aspergillosis
Deflazacort Vs. Prednisolone in Acute-stage ABPA
Oral glucocorticoids are currently the treatment of choice for allergic bronchopulmonary aspergillosis (ABPA). They not only suppress the immune hyperfunction but are also anti-inflammatory.
- Trial name
- NCT04227483
- Testing
- Deflazacort, Prednisolone
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Children Receiving Prednisone or Prednisolone or Methylprednisolone or Hydrocortisone
Pharmacokinetics of Glucocorticoids in Children (GLUCOPED)
The purpose of this study is to determine individual susceptibility factors (drug interactions, genetic factors such as enzyme polymorphism…) to explain wide interindividual variability towards corticosteroids (prednisone…
- Trial name
- GLUCOPED (NCT02252237)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Experimental Lung Inflammation
Validation of a Lung Inflammation Model in Healthy Volunteers by Radiological Tools and Glucocorticoid Treatment
The purpose of this study is to investigate the local and systemic inflammatory response and haemostatic alterations in the lungs after lipopolysaccharide (LPS) instillation and to determine the feasibility of imaging techniques…
- Trial name
- NCT01714427
- Testing
- Dexamethasone, Sterile isotonic saline
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Congenital Adrenal Hyperplasia
COrticosteroid in Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) results from a deficiency of a key enzyme in the biosynthesis of cortisol, mainly 21-hydroxylase, resulting in its classic form a neonatal salt loss syndrome and / or a virilization syndrome…
- Trial name
- COCA (NCT02552251)
- Testing
- Hormonal balance measurements, metabolic balance measurements, bone balance measurements
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Recurrent or Metastatic Cervical Cancer
Relacorilant and Nab-Paclitaxel in Recurrent or Metastatic Cervical Cancer
This phase II study will evaluate the efficacy and safety of relacorilant in combination with nab-paclitaxel in participants with recurrent or metastatic cervical cancer who have previously received platinum-based chemotherapy…
- Trial name
- STELLA (NCT07763496)
- Testing
- Relacorilant, Nab-paclitaxel
- Where
- 2 sites in France
- Volunteers
- 63 people
- Sponsor
- ARCAGY/ GINECO GROUP
Adrenal Insufficiency
The Prevalence of Secondary Adrenal Insufficiency in Patients With Exacerbation of COPD in Glucocorticoid Treatment Related to Differenct Gene Polymorphisms of the Glucocorticoid Receptor Gene
To investigate the correlation between four well-known polymorphisms of the glucocorticoid receptor gene (two with reduced sensitivity versus two with increased sensitivity) and the prevalence of secondary adrenal insufficiency…
- Trial name
- NCT03140761
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Sepsis, Severe, Septic Shock
Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
This study has been created to compare the addition of intravenous (IV) vitamin C, thiamine, and hydrocortisone to the usual standard of care of sepsis and septic shock.
- Trial name
- ORANGES (NCT03422159)
- Testing
- Ascorbic Acid, Thiamine, Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Community Medical Center, Toms River, NJ
Skin Atrophy
Study With a Topical Gel Containing TRIAC and DHEA in Subjects With Skin Atrophy Due to Glucocorticoids
An open, uncontrolled pharmacokinetic study with a new topical combination gel containing triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA) in subjects with skin atrophy due to topical treatment with…
- Trial name
- NCT03783988
- Testing
- DHEA and TRIAC
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Trophea Development AB
Osteoporosis, Rheumatoid Arthritis
GIOP Prevention Among People With Rheumatoid Arthritis
The ultimate objective of the proposed research is to improve the health-related quality of life of individuals with rheumatoid arthritis by reducing their risk of developing osteoporosis secondary to glucocorticoid therapy.
- Trial name
- NCT00609830
- Testing
- Tailored Materials, Tailored Materials Plus Physician Feedback, Generic Materials
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of North Carolina, Chapel Hill
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Bone Loss
Prevention of Glucocorticoid Induced Impairment of Bone Metabolism
Glucocorticoid (GC) therapy is used to treat a variety of inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease, bronchial asthma, allergies, ankylosing spondylitis and some forms of cancers.
- Trial name
- NCT04767711
- Testing
- Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475), Prednisolone
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Purpura, Thrombocytopenic, Idiopathic
The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9
A Prospective, Randomized, Open-Label, Multicenter Clinical Trial study to compare the efficacy and safety of ATRA plus eltrombopag compared to eltrombopag monotherapy in the treatment of steroid-resistant/relapsed immune…
- Trial name
- NCT05438875
- Testing
- all-trans retinoic acid, Eltrombopag
- Where
- 5 sites in China
- Volunteers
- 96 people
- Sponsor
- Peking University People's Hospital
Chronic Granulomatous Disease, Inflammatory Bowel Disease
Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease
Background: Bacteria that live inside the stomach and intestines are important for health. Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) can make people have unhealthy bacteria.
- Trial name
- NCT03983837
- Testing
- Neocate Splash
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)