Clinical trials: Glucocorticoids
Eosinophilic Esophagitis
Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)
Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, characterized by eosinophilic infiltration and gastrointestinal symptoms.
- Trial name
- FLUTE (NCT03191864)
- Testing
- APT-1011
- Where
- 75 sites in United States, Belgium and 4 more
- Volunteers
- 106 people
- Sponsor
- Adare Pharmaceuticals, Inc.
Congenital Adrenal Hyperplasia
COrticosteroid in Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) results from a deficiency of a key enzyme in the biosynthesis of cortisol, mainly 21-hydroxylase, resulting in its classic form a neonatal salt loss syndrome and / or a virilization syndrome…
- Trial name
- COCA (NCT02552251)
- Testing
- Hormonal balance measurements, metabolic balance measurements, bone balance measurements
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Giant Cell Arteritis
Methotrexate as Remission Maintenance Therapy After Remission-Induction With Tocilizumab and Glucocorticoids in Giant Cell Arteritis
The standard treatment for Giant Cell arteritis (GCA) is Glucocorticoids(GC), even if GC-related adverse events are commonly occuring. Therefore, other practises for reducing relapses and cumulative GC-doses are needed.
- Trial name
- MTXinGCA (NCT05623592)
- Testing
- Methotrexate, Sodium chloride
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- University of Bonn
Rheumatoid Arthritis
Intra-articular Glucocorticoid Treatment of the Elbow
BACKGROUND: Intra-articular glucocorticoid injections are frequently used to relieve symptoms of arthritis. Postinjection rest has been shown to improve the outcome of knee joint injections, but not for wrist injections.
- Trial name
- NCT00972530
- Testing
- immobilisation in a triangular sling
- Volunteers
- 90 people
- Sponsor
- Region Gävleborg
Atrial Fibrillation
Study to Assess the Safety, Tolerability, Pharmacokinetic of Thrv-1268
This is a single-center, randomized, double-blind, placebo-controlled study to be conducted in 2 parts: single ascending dose (SAD) incorporating a food effect arm and multiple ascending dose (MAD).
- Trial name
- NCT06507839
- Testing
- THRV-1268
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Brain Metastases, Melanoma
Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases
This is a monocentric, open label, randomized Phase II study in patients with brain metastasis from melanoma, lung or breast cancer, who require treatment with high-dose dexamethasone, as defined as a minimum of 8 mg daily based…
- Conditions
- Brain Metastases, Melanoma, Lung Cancer, Breast Cancer
- Trial name
- OPTIMAL (NCT04001725)
- Testing
- Dexamethasone, Metformin
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Glucocorticoid Effect
Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin
Supraphysiological doses of glucocorticoids (GCs) are widely prescribed as immunosuppressants and metabolic side effects such as obesity and diabetes are extremely common.
- Trial name
- Gluco-Met (NCT04659915)
- Testing
- Metformin 500 mg Oral Tablets + Prednisone 20mg Tablets
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
IgG4-related Disease
Study of Sirolimus in IgG4-related Disease
gG4-related disease (IgG4-RD) is a newly recognized systemic autoimmune disease that can involve the pan-creatobiliary tract, retroperitoneum/aorta, head and neck region, and salivary glands, et al.
- Trial name
- NCT05746689
- Testing
- Sirolimus
- Volunteers
- 20 people
- Sponsor
- Peking University International Hospital
Traumatic Birth
Glucocorticoid Administration After Traumatic Birth
This study has two components, an observational and a trial component. The observational part is being done to screen for postpartum posttraumatic stress disorder by collecting mental health assessments in women who are…
- Trial name
- NCT04852458
- Testing
- Intravenous (IV) hydrocortisone
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Michigan
Analgetic, Lung Cancer (NSCLC)
High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in…
- Conditions
- Analgetic, Lung Cancer (NSCLC), Video Assisted Thoracic Surgery (VATS), Glucocorticoid
- Trial name
- DEXTER (NCT07213375)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoporosis, Rheumatoid Arthritis
GIOP Prevention Among People With Rheumatoid Arthritis
The ultimate objective of the proposed research is to improve the health-related quality of life of individuals with rheumatoid arthritis by reducing their risk of developing osteoporosis secondary to glucocorticoid therapy.
- Trial name
- NCT00609830
- Testing
- Tailored Materials, Tailored Materials Plus Physician Feedback, Generic Materials
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of North Carolina, Chapel Hill
Achilles Tendinopathy
Achilles Tendinopathy Treated With Training and Injections
The purpose of this study is to compare in a randomized double blinded controlled trial the effect of heavy slow resistance exercises combined with ultrasound guided injections with local anesthetic with or without…
- Trial name
- NCT02580630
- Testing
- Reduction in running and jumping, Training, Ultrasound guided injection with Glucocorticosteroid
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Acute Respiratory Distress Syndrome
Glucocorticoid Therapy for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of inflammatory lung injury characterized by increased pulmonary vascular permeability, loss of aerated lung tissue, severe hypoxemia and impaired compliance.
- Trial name
- NCT05401812
- Testing
- Intravenous glucocorticoid therapy
- Sponsor
- National Taiwan University Hospital
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Adrenal Insufficiency, Excess Androgen
Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia
Background: Congenital adrenal hyperplasia (CAH) is a genetic disorder of the adrenal gland. The adrenal gland is located in the abdomen and produces small amounts of hormones such as cortisol, aldosterone, and androgen.
- Conditions
- Adrenal Insufficiency, Excess Androgen, Congenital Adrenal Hyperplasia (CAH)
- Trial name
- NCT01859312
- Testing
- Hydrocortisone (Solucortef), Insulin pump (Medtronic)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Distal Radius Fracture
Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
The purpose of this investigation is to compare functional outcome measures and range of motion for patients receiving glucocorticoid (GC) injections versus those not receiving GCs for the treatment of distal radius fractures.
- Trial name
- NCT03898154
- Testing
- Dexamethasone, Methylprednisolone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- C. Liam Dwyer
Osteoporosis
Comparison of the Effects of 2 Drugs on Lumbar Spine Volumetric BMD in Men With Glucocorticoid-Induced Osteoporosis
The objective of this study is to test the hypothesis that teriparatide is superior to the active comparator in the change from baseline to 18 months of lumbar spine volumetric trabecular bone mineral density (BMD) in males with…
- Trial name
- EuroGIOPS (NCT00503399)
- Testing
- Teriparatide, Risedronate
- Where
- 13 sites in Germany, Greece and 2 more
- Volunteers
- 92 people
- Sponsor
- Eli Lilly and Company
Glucocorticoids, Obesity and Overweight
Acute Effects of Ultra-processed Versus Unprocessed Foods on Glucocorticoid Secretion in Healthy Individuals
The investigators aim to understand whether the acute cortisol response to food differs between differently processed foods. In this monocentric, randomized, cross-over, open-label study, 20 healthy volunteers will receive two…
- Conditions
- Glucocorticoids, Obesity and Overweight, Food Effect
- Trial name
- UltraCort (NCT06724692)
- Testing
- Ultra-processed breakfast, Low-processed breakfast
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Posttraumatic Stress Disorder
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of…
- Trial name
- VA CORT (NCT01090180)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Hyperglycemia Steroid-induced
Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy
Objective: to determine which regimen results in best glycemic control and safety profile, expressed as glucose values within target range and occurrence of hypoglycemia.
- Trial name
- GluCon-Chemo (NCT02155374)
- Testing
- Sliding scale insulin, Intermediate acting insulin, Dietary advice
- Where
- 3 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Slotervaart Hospital