Clinical trials: Glucocorticoids
Chronic Rhinosinusitis Without Nasal Polyps
Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The purpose of this study is to determine the most effective route to administer steroids to patients with chronic sinusitis, specifically a type of chronic sinusitis not associated with nasal polyps (CRSsNP).
- Trial name
- NCT01676415
- Testing
- Prednisone, Topical mometasone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
COVID-19 Infections
Glucocorticoid Therapy for COVID-19 Critically Ill Patients With Severe Acute Respiratory Failure
In this multi-center, randomized, control study, the investigators will evaluate the efficacy and safety of glucocorticoid in combination with standard care for COVID-19 patents with Severe acute respiratory failure.
- Trial name
- NCT04244591
- Testing
- methylprednisolone therapy, Standard care
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Obstructive Pulmonary Disease
Analysis of Relationship Between Metabolic Biomarkers and Efficacy of Glucocorticoid in AECOPD
Evidences have shown that systemic glucocorticoid cannot not be benefit to all of the patients with AECOPD. The problem that how the clinicians can screen the patients who can benefit from systemic glucocorticoid needs to be…
- Trial name
- NCT04964037
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Autoimmune Bullous Dermatosis, Glucocorticoids Toxicity
Investigating the Morbidity of Glucocorticoid Use in Patients With Autoimmune Bullous Diseases (AIBDs)
This project utilised the validated glucocorticoid toxicity index (GTI) tool to assess the morbidity of glucocorticoid-use in patients with autoimmune bullous disease.
- Trial name
- NCT05525065
- Testing
- GlucoCorticoid
- Where
- Australia
- Volunteers
- 138 people
- Sponsor
- Premier Specialists, Australia
Systemic Lupus Erythematosus
GL701 (Prestara™) in Women With Systemic Lupus Erythematosus Receiving Treatment With Glucocorticoids
Open label safety and efficacy follow-up.
- Trial name
- NCT00082511
- Testing
- Prasterone (GL701)
- Where
- 22 sites in United States, Mexico
- Volunteers
- 114 people
- Sponsor
- Genelabs Technologies
Achilles Tendinopathy
Achilles Tendinopathy Treated With Training and Injections
The purpose of this study is to compare in a randomized double blinded controlled trial the effect of heavy slow resistance exercises combined with ultrasound guided injections with local anesthetic with or without…
- Trial name
- NCT02580630
- Testing
- Reduction in running and jumping, Training, Ultrasound guided injection with Glucocorticosteroid
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Subclinical Cushing's
Glucocorticoid Receptor Antagonism in Subclinical Cushings
The purpose of this study is to assess the effects of reducing the activity of endogenous glucocorticoid in patients with low-grade cortisol excess
- Trial name
- NCT00721201
- Testing
- Mifepristone
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Graves Ophthalmopathy
A Randomized Clinical Trial of Intravenous Methylprednisolone With 2 Protocols in Patients With Graves Orbitopathy
Intravenous glucocorticoid (IVGC) is an accessible and effective therapy for Graves orbitopathy (GO); the 4.5-g weekly protocol is well studied, but many details of treatment protocols need to be clarified.
- Trial name
- NCT06510114
- Testing
- methylprednisolone(daily scheme), methylprednisolone(weekly scheme)
- Volunteers
- 150 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Healthy Volunteers
A Midazolam Drug Interaction Study With PF-04171327
The purpose of this study is to investigate the effects of multiple doses of PF-04171327 on the blood levels (pharmacokinetics) of midazolam
- Trial name
- NCT00987038
- Testing
- PF-04171327 25 mg, Midazolam 2 mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Adrenal Insufficiency
Prevalence of Adrenal Insufficiency in Kidney Transplanted Patients in Glucocorticoid Treatment
The primary purpose of this study is to determine the prevalence of adrenal insufficiency in a population of patients with kidney transplants receiving low dose prednisone treatment.
- Trial name
- NCT03136562
- Testing
- Synacthen test
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteonecrosis, Osteonecrosis of the Femoral Head
A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral Head
This is a multicenter, randomized (similar to drawing lots, where the treatment you receive is not chosen by you or the researchers), controlled, blinded (the three dose groups of the investigational drug are blinded, meaning…
- Trial name
- LLP2A-Ale (NCT07471880)
- Testing
- RAB001 high dose, RAB001 medium dose, RAB001 low dose
- Where
- China
- Volunteers
- 161 people
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Giant Cell Arteritis
A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)
To investigate the safety and efficacy of abatacept with steroid treatment in comparison to steroid treatment alone in up to a 28 week taper of steroid treatment to sustain remission of Giant Cell Arteritis in adults.
- Trial name
- NCT03192969
- Testing
- Abatacept, Glucocorticoid Treatment
- Where
- 99 sites in United States, Australia and 19 more
- Sponsor
- Bristol-Myers Squibb
Osteoporosis
A Research Study to Evaluate the Safety and Effectiveness of MK0217 to Prevent and Treat Bone Loss (0217-193)(COMPLETED)
A research study to see how safe and effective MK0217 is when taken weekly for the prevention and treatment of steroid induced bone loss.
- Trial name
- NCT00480766
- Testing
- MK0217/Duration of Treatment : 12 Months
- Volunteers
- 173 people
- Sponsor
- Organon and Co
Asthma, Bone Density, Low
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.
- Conditions
- Asthma, Bone Density, Low, Oral Steroid-Dependent Asthma (Disorder)
- Trial name
- NCT04518722
- Testing
- CT Scan, DXA Scan, Steroid Intake Questionnaire
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Iowa
Body Composition, Beneficial
Impact of Physiological, Lifestyle and Genetic Factors on Body Composition
Research has shown that body composition is a key component of health and future disease risk. Being overweight and obese is associated with a higher body fat composition, and a greater risk of developing type II diabetes and…
- Trial name
- BODYCON (NCT02658539)
- Where
- United Kingdom
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- University of Reading
Carpal Tunnel Syndrome (CTS), Glucocorticoid
Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome
This study aims to compare the efficacy and outcomes of perineural injection with 5% dextrose, local ozone and glucocorticoid injection in the management of carpal tunnel syndrome.
- Conditions
- Carpal Tunnel Syndrome (CTS), Glucocorticoid, Pain, Dextrose
- Trial name
- NCT07498998
- Testing
- Perineural injection with 5% dextrose (D5W)., Local ozone injection, Local glucocorticoid injection (dexamethasone).
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Asthma
Effect of Symbicort on GR Localisation in Asthma
To investigate a possible interaction between formoterol and budesonide on GR-translocation and to compare the effect of different doses of Symbicort (80/4.5 and 2x80/4.5 mcg) with the effect of budesonide (200 mcg and 800 mcg)…
- Trial name
- NCT00159263
- Testing
- Formoterol Inhalant Powder, Budesonide Powder, Budesonide and Formoterol Product
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Gastrointestinal Cancer, Dietary Modification
Study of Parenteral Nutrition to Patients With Gastrointestinal Cancer
Clinical background: Weight loss is a common problem in patients suffering from gastrointestinal cancer. It is demonstrated that the prognosis for cancer patients with weight loss is worse than that for weight stable patients.
- Conditions
- Gastrointestinal Cancer, Dietary Modification, Cancer Cachexia, Quality of Life
- Trial name
- NCT02066363
- Testing
- Dietician advise, Parenteral nutrition
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Rheumatoid Arthritis
Dynamic Treatment Regiments for Glucocorticoid Tapering
The purpose of this clinical trial is to better understand how people with rheumatoid arthritis (RA) respond to gradual dose reduction, or "tapering", of steroid medications like prednisone.
- Trial name
- SMART-RA (NCT06072768)
- Testing
- 15-day taper prednisone, 150-day taper prednisone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Lipodystrophy
Corticosteroid-induced Lipodystrophy and Adipokines
Hypothesis: systemic therapy with corticosteroid induces morphological changes (e.g., moon face, buffalo neck) called lipodystrophy (LD).
- Trial name
- ADIPOKINES (NCT00822042)
- Testing
- Samples and procedures
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris