Clinical trials: Glucocorticoids
Glucocorticoid-induced Osteoporosis
A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With Glucocorticoid-induced Osteoporosis in Mainland China
The main objective of this study is to evaluate the efficacy of Prolia® in improving bone mass density (BMD) of lumbar spine at month 12.
- Trial name
- NCT06588153
- Testing
- Prolia®
- Where
- 16 sites in China
- Volunteers
- 102 people
- Sponsor
- Amgen
Dexamethasone, Glucocorticoids
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after breast cancer surgery, with removal of the breast (mastectomy).
- Conditions
- Dexamethasone, Glucocorticoids, Mastectomy, Breast Cancer
- Trial name
- DEX-MAS (NCT03125941)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adrenal Insufficiency, Excess Androgen
Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia
Background: Congenital adrenal hyperplasia (CAH) is a genetic disorder of the adrenal gland. The adrenal gland is located in the abdomen and produces small amounts of hormones such as cortisol, aldosterone, and androgen.
- Conditions
- Adrenal Insufficiency, Excess Androgen, Congenital Adrenal Hyperplasia (CAH)
- Trial name
- NCT01859312
- Testing
- Hydrocortisone (Solucortef), Insulin pump (Medtronic)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Osteoporosis
Denosumab (DMAB) Discontinuation And Switching In Glucocorticoid-Induced Osteoporosis (GIOP): A Pilot Study
Investigators will test the hypothesis that an increase in bone turnover markers (e.g. carboxy-terminal collagen crosslinks (CTX) and P1NP) in patients currently taking chronic glucocorticoids will be attenuated more in those who…
- Trial name
- NCT04177940
- Testing
- DMAB Discontinuation and Switching
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Vertebral Fracture, Osteonecrosis
Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid
Osteoporotic vertebral fracture (VF) and osteonecrosis of the femoral head (OFH) are major concerns in patients with systemic rheumatic diseases treated with high-dose glucocorticoids (GCs).
- Conditions
- Vertebral Fracture, Osteonecrosis, Rheumatic Diseases
- Trial name
- NCT00679978
- Volunteers
- 60 people
- Sponsor
- Saitama Medical University
Community-Acquired Pneumonia
Corticoids in Severe Community-Acquired Pneumonia (CAP)
The purpose of this study is to assess the efficacy of glucocorticoids as an adjuvant therapy in patients with severe community-acquired pneumonia (CAP) (Fine V).
- Trial name
- NCT00908713
- Testing
- methylprednisolone
- Where
- 3 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Wheezing
Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children
We can not predict which wheezing child younger than 3 years of age benefits from systemic glucocorticoid and which one does not.
- Trial name
- VINKU (NCT00494624)
- Testing
- prednisolone
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- University of Turku
Pulmonary Sarcoidosis
Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS).
The aim of the study is determining the non-inferiority in the overall success rate and the safety for a combination therapy with hydroxychloroquine plus low dose glucocorticoids compared to that for high dose glucocorticoids at…
- Trial name
- HySSAS (NCT02200146)
- Testing
- Prednisone, Hydroxychloroquine + Prednisone
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- University of Milano Bicocca
Graft-vs-Host Disease
Research Study of Visilizumab for Treatment of Glucocorticoid- Refractory Graft Versus Host Disease
The purpose of this phase II study is to evaluate an investigational monoclonal antibody for the treatment of glucocorticoid-refractory Graft Versus Host Disease (GVHD).
- Trial name
- NCT00032279
- Testing
- Visilizumab
- Where
- 17 sites in United States
- Volunteers
- 80 people
- Sponsor
- Fred Hutchinson Cancer Center
Preterm Birth, Premature Birth
Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome.
- Conditions
- Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature
- Trial name
- SNACS (NCT05114096)
- Testing
- Celestone + Celestone
- Where
- 25 sites in Canada
- Volunteers
- 3,254 people
- Sponsor
- McMaster University
Distal Radius Fracture
Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
The purpose of this investigation is to compare functional outcome measures and range of motion for patients receiving glucocorticoid (GC) injections versus those not receiving GCs for the treatment of distal radius fractures.
- Trial name
- NCT03898154
- Testing
- Dexamethasone, Methylprednisolone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- C. Liam Dwyer
Crohn's Disease, Nephrotic Syndrome
Glucocorticoid-induced Osteopenia in Children
The purpose of this study is to characterize the skeletal deficits and risk factors for impaired skeletal development in children requiring glucocorticoid therapy.
- Trial name
- NCT00289328
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Osteoporosis
Eldecalcitol for GLucocorticoid Induced OsteopoRosIs Versus Alfacalcidol
The purpose of this study is to evaluate the efficacy and safety of eldecalcitol monotherapy compared with alfacalcidol monotherapy in patients with glucocorticoid-induced osteoporosis, using a randomized, open-label…
- Trial name
- e-GLORIA (NCT01974167)
- Testing
- Eldecalcitol, Alfacalcidol
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- e-GLORIA trial Protocol Review Committee
Glucocorticoid Effect
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- NCT05919992
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Neuromyelitis Optica (NMO), Neuromyelitis Optica Spectrum Disorders (NMOSD)
Slow vs. Rapid Glucocorticoids Tapering With Inebilizumab in NMOSD
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system autoimmune condition mainly involving the spinal cord, optic nerves, and area postrema.
- Trial name
- STARGlu-NMO (NCT07132398)
- Testing
- Slow-tapering glucocorticoids + Inebilizumab, Rapid-tapering glucocorticoids + Inebilizumab
- Volunteers
- 170 people
- Sponsor
- Tianjin Medical University General Hospital
Glucocorticoids, Obesity and Overweight
Acute Effects of Ultra-processed Versus Unprocessed Foods on Glucocorticoid Secretion in Healthy Individuals
The investigators aim to understand whether the acute cortisol response to food differs between differently processed foods. In this monocentric, randomized, cross-over, open-label study, 20 healthy volunteers will receive two…
- Conditions
- Glucocorticoids, Obesity and Overweight, Food Effect
- Trial name
- UltraCort (NCT06724692)
- Testing
- Ultra-processed breakfast, Low-processed breakfast
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Graft-versus-host-disease (GVHD)
Study of Ruxolitinib in Sclerotic Chronic Graft-Versus-Host Disease After Failure of Systemic Glucocorticoids
The primary objective of the study is to examine the efficacy of ruxolitinib in patients with sclerotic chronic graft-versus-host disease (GVHD).
- Trial name
- NCT03616184
- Testing
- Ruxolitinib
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Nebraska
Hypertrophic Scars, Keloids
Scars After Central Venous Catheters
Most children with cancer need a central venous catheter. These catheters are typically placed on the anterior thorax, where the risk of hypertrophic scarring and keloid development is greatly enhanced.
- Trial name
- NCT01113125
- Testing
- Betamethason-17-valerate and fusidic acid, Fusidic Acid
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Mette Møller Handrup
Bronchiolitis, Viral
Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis
The purpose of this study is to to demonstrate that a 7-day course of systemic glucocorticoids decreases the inflammatory activity of moderate or severe bronchiolitis in paediatric patients compared to the standard treatment.
- Trial name
- NCT02571517
- Testing
- Glucocorticoids
- Volunteers
- 94 people
- Sponsor
- Fundació Sant Joan de Déu
Obesity, Visceral Obesity
Nutrition and Energy Restriction for Cancer Prevention
This study evaluates the effect of intermittent calorie restriction versus continued calorie restriction on weight loss, gene expression profile of subcutaneous adipose tissue and abdominal fat distribution.
- Conditions
- Obesity, Visceral Obesity, Weight Loss, Metabolic Diseases
- Trial name
- HELENA (NCT02449148)
- Testing
- Calorie Restriction
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center