Clinical trials: Glucocorticoids
Respiratory Distress Syndrome, Intraventricular Haemorrhage
Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth
Administration of steroid to the mother in imminent preterm delivery is a known effective practice to decrease the risk of respiratory distress syndrome and intraventricular haemorrhage in preterm infants if given with a week of…
- Trial name
- NCT00295464
- Testing
- Betamethasone sodium phos (drug)
- Where
- 10 sites in Finland
- Volunteers
- 440 people
- Sponsor
- University of Oulu
Vogt-Koyanagi-Harada Disease, Mycophenolate Mofetil
A Study of Mycophenolate Mofetil Combined With Glucocorticoid Therapy in Relapse Vogt-Koyanagi-Harada Disease
This project is designed to test the hypothesis that Mycophenolate Mofetil is clinically useful for patients with relapse Vogt-Koyanagi-Harada disease
- Trial name
- NCT05627739
- Testing
- Mycophenolate Mofetil
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University
Cushing Syndrome Related to Cortisolic Adenoma
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome
The purpose of this trial is to investigate the impact of cortisol on adipose tissue functions, distribution and morphology. Patient with endogenous blood cortisol excess exhibit changes in adipose tissue, with fat gain in the…
- Trial name
- LIPOCUSH (NCT01688349)
- Testing
- analyze the role of glucocorticoid in AT distribution.
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Metastases, Melanoma
Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases
This is a monocentric, open label, randomized Phase II study in patients with brain metastasis from melanoma, lung or breast cancer, who require treatment with high-dose dexamethasone, as defined as a minimum of 8 mg daily based…
- Conditions
- Brain Metastases, Melanoma, Lung Cancer, Breast Cancer
- Trial name
- OPTIMAL (NCT04001725)
- Testing
- Dexamethasone, Metformin
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Allergic Reaction to Contrast Media, Hypersensitivity Reaction
1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study
1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen)…
- Conditions
- Allergic Reaction to Contrast Media, Hypersensitivity Reaction, Computed Tomography, Premedication
- Trial name
- PAGE1 (NCT07268248)
- Testing
- IV glucocorticoid and antihistamine, IV glucocorticoid and antihistamine (standard of care)
- Volunteers
- 540 people
- Sponsor
- Paul Peng, MD PhD MSCR
Peripheral Nerve Block, Pain
The Analgesic Effect of Combined Nerve Block and Systemic High Dose Glucocorticoid After Total Knee Arthroplasty.
Purpose: The purpose of this study is to evaluate the postoperative analgesic effect of a combined Saphenous nerve block and Obturator nerve block with local infiltration analgesia in the tissue around the knee after total…
- Trial name
- HOBSALIplus (NCT02374008)
- Testing
- Ropivacaine
- Volunteers
- 74 people
- Sponsor
- Regionshospitalet Silkeborg
Congenital Heart Disease, Disorder of Fetus or Newborn
Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Randomized controlled trial of the use of glucocorticoids to improve the clinical course of neonates post-cardiopulmonary bypass (CPB).
- Trial name
- NCT00934843
- Testing
- methylprednisolone (IVMP), methylprednisolone (two doses IVMP)
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Medical University of South Carolina
Glucocorticosteroid Refractory Acute GVHD
Phase II Study of Tocilizumab for Patients With Glucocorticoid-refractory Acute GVHD After Allogeneic Hematopoetic Stem Cell Transplant (HSCT)
The purpose of this study is to determine if Tocilizumab is a safe and effective treatment for steroid-refractory acute graft versus host disease.
- Trial name
- NCT01757197
- Testing
- Toclizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Weill Medical College of Cornell University
Idiopathic Pulmonary Hemosiderosis, Leflunomide
Leflunomide for Idiopathic Pulmonary Hemosiderosis in Children
The goal of this clinical trial is to compare Leflunomide in Idiopathic pulmonary hemosiderosis. The main questions it aims to answer are: The efficacy and safety of Leflunomide in Idiopathic pulmonary hemosiderosis The mechanism…
- Trial name
- Lef for IPH (NCT05937191)
- Testing
- Leflunomide, Steroid Drug
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Gulf War Illness
TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset
Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances…
- Trial name
- E/M (NCT04254627)
- Testing
- Etanercept, Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Nova Southeastern University
Systemic Lupus Erythematosus, Glucocorticoids
Glucocorticoids Withdrawal in Early Systemic Lupus Erythematosus
This is a 36 months, randomized, double-blind, placebo-controlled, parallel-groups, equivalence multicenter trial in patients with inactive Systemic Lupus Erythematosus to evaluate if low disease activity can be sustained with…
- Conditions
- Systemic Lupus Erythematosus, Glucocorticoids, Therapy Withdrawal
- Trial name
- NCT03804723
- Testing
- oral Prednisone 5mg
- Volunteers
- 321 people
- Sponsor
- University of Pisa
Mild Hypercortisolism
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism
The purpose of this study is to determine whether mifepristone is an effective treatment for hyperglycemia due to mild hypercortisolism.
- Trial name
- NCT01990560
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus, Type 2
Effect of Glucocorticoid on Exogenous Insulin Antibody Syndrome
Diabetic patients who have long-term insulin used can product antibody against exogenous insulin, the investigators named this condition Exogenous insulin antibody syndrome (EIAs).
- Trial name
- NCT04357392
- Testing
- Prednisone
- Volunteers
- 20 people
- Sponsor
- chenfengling
Asthma
Appropriate Inhaler Use of Tiotropium As Add-on Therapy in Symptomatic Asthma
This pragmatic, two-arm, randomized controlled trial study aim to survey the inhaler errors of add-on tiotropium therapy with ICS+LABA in real-world practice of asthma patients and the efficacy of recheck stratage of inhaler…
- Trial name
- NCT04696965
- Testing
- Correct/recheck strategy, Usual verbal instruction
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Disease
Effects Of Oral Prednisolone On Bone Metabolism In Patients With Chronic Obstructive Pulmonary Disease
The aim of this study is to establish associations between blood and urine markers of bone metabolism with histomorphometric changes (changes in the actual bone structure) resulting from short term oral prednisolone treatment in…
- Trial name
- NCT00384306
- Testing
- prednisolone
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Hyperglycemia
CrossFit Exercise to Improve Glucose Control for Overweight and Obese Adults
The purpose of this study was to examine the differences in glucose control, fitness, and body composition between a standard aerobic and resistance exercise training program and a shorter-duration, high-intensity CrossFit…
- Trial name
- NCT02185872
- Testing
- High-Intensity Functional Training, Aerobic and Resistance Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Addison Disease
Biomarker(s) for Glucocorticoids
The investigators have shown that patients with adrenal insufficiency (Addison's disease), a rare disorder, have doubled the expected mortality rate in Sweden despite Standard of Care glucocorticoid (GC) replacement.
- Trial name
- BIOCORT (NCT02152553)
- Testing
- Hydrocortisone
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Vastra Gotaland Region
Immune Thrombocytopenia, Treatment
Rituximab Combining Anti-CD38 Monoclonal Antibody Versus Rituximab in the Management of Primary Immune Thrombocytopenia (ITP)
This randomized, open-label study aim to compare the efficacy and safety of rituximab combining anti-CD38 monoclonal antibody with rituximab in ITP patients.This study will be conducted in ITP patients who had not responded to or…
- Trial name
- NCT07234019
- Testing
- Daratumumab（Anti-CD38 Monoclonal Antibody）, Rituximab
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
21-hydroxylase; Defect
Effects of "in UTERO" Exposure to Glucocorticoids
The main objective of this study is to show that the fetal exposure to excess of glucocorticoids is associated with a deficiency of the function beta insulin in the offspring adult.
- Trial name
- GLUCODEX (NCT01367106)
- Testing
- Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment
This is a controlled, open study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on clinical, anthropometric parameters, metabolic syndrome, hormonal profile…
- Trial name
- CareOnTIME (NCT03760835)
- Testing
- Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone), Dual release hydrocortisone (plenadren)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University