Clinical trials: Glucocorticoids
Mild Cognitive Impairment, Chronic Inflammation
The Grounded Brain: How Sleeping Grounded Affects Memory and Perceptions
Grounding (Earthing) refers to the practice of contacting the Earth or a properly installed grounding mat with the body. Previous studies on grounding have shown positive effects body-wide inflammation, acute and chronic pain…
- Trial name
- NCT05050812
- Testing
- grounding mat
- Volunteers
- 8 people
- Sponsor
- California Institute of Integral Studies
Obesity, Metabolic Syndrome X
Exercise Training and Hepatic Metabolism in Overweight/Obese Adolescent
The HEPAFIT Study aims to examine whether a 6-months physical education program has benefits on hepatic metabolism and cardiovascular health as well as on selected physical fitness and mental health outcomes among adolescent…
- Conditions
- Obesity, Metabolic Syndrome X, Lipid Metabolism Disorders, Body Composition, Beneficial
- Trial name
- HEPAFIT (NCT02753231)
- Testing
- Low physical activity program, High physical activity program, Low and High physical activity program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Glucocorticoids, Overweight and Obesity
Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake
The investigator aim to understand whether food-induced glucocorticoids influence fat mass in overweight and obese people. In a randomized, cross-over study, 23 overweight and obese volunteers will receive a block and replace…
- Conditions
- Glucocorticoids, Overweight and Obesity, Overeating
- Trial name
- Gluco-Max (NCT06556277)
- Testing
- Metyrapone And Hydrocortisone
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Rheumatoid Arthritis
Clinical Trial on the Efficacy of Raloxifene on Disease Activity in Rheumatoid Arthritis
The investigators select 40 postmenopausal women suffering from RA with 2.5<DAS28<5.5 referring to rheumatology clinics of Mashhad university of medical sciences and randomly divide them into intervention group and placebo group.
- Trial name
- NCT02982083
- Testing
- Raloxifene hydrochloride
- Volunteers
- 34 people
- Sponsor
- Sara Saeidi Shahri
Breast Cancer
Abraxane® With or Without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer
This is a randomized, placebo-controlled, double-blind, phase II trial of nab-paclitaxel with or without mifepristone for advanced, glucocorticoid receptor-positive, triple-negative breast cancer.
- Trial name
- NCT02788981
- Testing
- Mifepristone, Nab-Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Chicago
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Asthma
A New Modified-release Tablet Formulation of Prednisone (Lodotra®) in Patients With Nocturnal Asthma
The purpose of the study is to evaluate in subjects suffering from nocturnal asthma, the efficacy and safety of modified release Prednisone on signs and symptoms.
- Trial name
- MONA (NCT00686335)
- Testing
- Lodotra, Cortancyl
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Amgen
Osteoporosis
Denosumab in Current Users of Bisphosphonates for Glucocorticoid-induced Osteoporosis
The purpose of this study is to study the efficacy of denosumab, a new drug, in the treatment of osteoporosis in patients using bisphosphonates.
- Trial name
- NCT01465568
- Testing
- Denosumab, bisphosphonates
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Tuen Mun Hospital
Rupture of Anterior Cruciate Ligament
COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined
Recent studies on molar surgery have shown that a combination of a glucocorticoid and NSAID or COX-2 selective inhibitor gives better pain relief than either of the drugs used separately.
- Trial name
- NCT01361789
- Testing
- parecoxib, valdecoxib, etoricoxib, Dexamethasone, parecoxib, valdecoxib, parecoxib and dexamethasone
- Where
- Norway
- Volunteers
- 93 people
- Sponsor
- Asker & Baerum Hospital
Acute Lung Injury, ARDS, Human
Steroids in Patients With Early ARDS
Scientific background. Dysregulated systemic inflammation is a key pathogenetic mechanism for morbidity and mortality in ALI/ARDS, and is associated with tissue insensitivity and/or resistance to inappropriately elevated…
- Trial name
- NCT00562835
- Testing
- Methylprednisolone, Normal saline intravenously and vitamin B1 per os
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Catholic University of the Sacred Heart
Plantar Fasciitis
Optimal Treatment of Plantar Fasciitis: Physical Training, Glucocorticoid Injections or a Combination Thereof.
The purpose of this study is to determine whether reduced load to patients with plantar fasciitis (reduced standing, walking, landing) together with either controlled heavy resistance training or glucocorticosteroid injection or…
- Trial name
- NCT01994759
- Testing
- Training, Glucocorticosteroid injection, Reduction in impact
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Bispebjerg Hospital
Acute Pain, Procedural Anxiety
VR for Steroid Joint Injections - Feasibility
The goal of the project is to implement virtual reality for pain and anxiety management for patients undergoing intra-articular glucocorticoid injections in the outpatient pediatric rheumatology clinic.
- Conditions
- Acute Pain, Procedural Anxiety, Juvenile Idiopahtic Arthritis
- Trial name
- NCT07778069
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Giant Cell Arteritis
Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis
OBJECTIVES: I. Compare the long term outcomes in patients with giant cell arteritis after glucocorticoid treatment with or without methotrexate. II.
- Trial name
- NCT00004686
- Testing
- methotrexate, prednisone
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
STEMI - ST Elevation Myocardial Infarction
Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial
BACKGROUND Myocardial reperfusion with the use of primary percutaneous coronary intervention (PCI) including stent implantation is the most efficacious treatment for patients with (STEMI) and improves prognosis significantly.
- Trial name
- PULSE-MI 2 (NCT07478003)
- Testing
- Methylprednisolone 250 mg, NaCl (0,9%)
- Where
- 4 sites in Denmark
- Volunteers
- 5,204 people
- Sponsor
- Thomas Engstrom
Ischemia-reperfusion Injury, No-reflow
Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Glucocorticoid Treatment for No-Reflow in STEMI
The goal of this clinical trial is to improve reperfusion therapy in STEMI patients with no-reflow phenomenon. Based on literature review and pathological studies, the investigators believe that myocardial ischemia-reperfusion…
- Trial name
- GCT-NR-STEMI (NCT06552442)
- Testing
- Methylprednisolone
- Where
- Ukraine
- Volunteers
- 10 people
- Sponsor
- Amosov National Institute of Cardiovascular Surgery
Traumatic Brain Injury, Trauma
Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury
Traumatic brained injured (TBI) patients frequently suffered from glucocorticoid insufficiency that is associated with a raise in the rate of pneumonia.
- Conditions
- Traumatic Brain Injury, Trauma, Adrenal Insufficiency, Pneumonia
- Trial name
- Corti-TC (NCT01093261)
- Testing
- Hydrocortisone Fludrocortisone
- Where
- 18 sites in France
- Volunteers
- 336 people
- Sponsor
- Nantes University Hospital
Alcohol Drinking, Drinking Behavior
Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking
The purpose of this study is to determine whether hydrocortisone biases formation of alcohol-related memories to potentiate drinking.
- Conditions
- Alcohol Drinking, Drinking Behavior, Episodic Memory, Long-term Memory
- Trial name
- NCT04896489
- Testing
- Hydrocortisone 20 MG
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yale University
Depressive Disorder, Fatigue Syndrome, Chronic
Glucocorticoid Effects on Cellular Cytokine Release
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
- Conditions
- Depressive Disorder, Fatigue Syndrome, Chronic, Fibromyalgia, Healthy
- Trial name
- NCT00001415
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Heavy Menstrual Bleeding
Dexamethasone for Excessive Menstruation
This study builds on previous research which has provided compelling evidence that deficient activity of glucocorticoids in the endometrium is a cause of increased menstrual bleeding.
- Trial name
- dexFEM (NCT01769820)
- Testing
- Dexamethasone
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- University of Edinburgh
Granulomatosis With Polyangiitis, Wegener Granulomatosis
The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose glucocorticoids ( 5 mg/day of prednisone) as…
- Conditions
- Granulomatosis With Polyangiitis, Wegener Granulomatosis, Vasculitis
- Trial name
- TAPIR (NCT01933724)
- Testing
- 5 mg prednisone, 0 mg prednisone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of South Florida