Clinical trials: Glucocorticoids
Rheumatoid Arthritis
A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
The purpose of the study is to compare the effects of methotrexate (MTX) alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab (IFX) on MRI-detected synovitis, bone edema and erosive changes in early…
- Trial name
- NCT00396747
- Testing
- Infliximab, methylprednisolone, methotrexate, Methotrexate, Methotrexate + Methylprednisolone
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Université Catholique de Louvain
Patients With Glucocorticoid Treatment
Metformin to Prevent Metabolic Complications in Glucocorticoid Excess
The purpose of this study is to evaluate if a treatment with metformin compared to placebo reduces metabolic side-effects in patients with glucocorticoid treatment over three months time.
- Trial name
- NCT01187849
- Testing
- Metformin
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Basel, Switzerland
Complications
Preoperative Glucocorticoid Use in Major Hepatectomy
Background: Reducing postoperative complications remains a dominant challenge for all clinicians. By minimizing the incidence of adverse outcomes, health care costs and patient recovery can be improved.
- Trial name
- NCT01997658
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Post-Traumatic Stress Disorders, Healthy
Effects of Hydrocortisone in Patients With Post-Traumatic Stress Disorder
The purpose of this study is to determine whether people who develop Post-Traumatic Stress Disorder (PTSD) after a trauma have increased sensitivity to the effects of a stress hormone.
- Trial name
- NCT00039715
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Adults
The Dose Response of Prednisone on Biochemical and Clinical Makers in Adult Healthy Volunteers
The purpose of this study is to further access the utility of biochemical and clinical biomarkers for glucocorticoid-mediated anti-inflammatory effects and safety endpoints against which dissociated agonists of the glucocorticoid…
- Trial name
- NCT02767089
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pfizer
Osteoarthritis, Hip
Systemic Steroids for Peripheral Nerve Blocks
This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.
- Trial name
- NCT02464176
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Glucocorticoid Resistant ICIs-related Myocarditis
The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis
The efficacy and safety of Tofacitinib in patients with glucocorticoid resistant ICIs-related myocarditis: a single-arm, prospective, phase 2 trial
- Trial name
- NCT06393972
- Testing
- Tofacitinib 5 MG BID
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastrointestinal and Digestive Disorder
Study of Teprenone in the Treatment of Glucocorticoid-Induced Drug-Related Gastrointestinal Injury
Objective: To evaluate the efficacy, safety, and adherence of the gastric mucosal protective agent teprenone in the treatment of glucocorticoid-induced drug-related gastrointestinal injury.
- Trial name
- NCT07654049
- Testing
- Omeprazole, Teprenone
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus
Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes
Steroid injections used to treat painful joints can temporarily increase glucose levels in people with type 2 diabetes. This study will test whether a short course of pre-emptive neutral protamine Hagedorn, NPH, insulin can…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus, Osteoarthritis, Knee
- Trial name
- PREVENT-SIH (NCT07757464)
- Testing
- Insulin Isophane Human, NPH, Pre-emptive Algorithm, Triamcinolone Acetonide Knee Injection
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- Shifa International Hospital
Asthma
The Study Will Evaluate the Efficacy of AZD5423 in Patients With Mild Asthma Challenged With an Inhaled Allergen
The purpose of this study is to evaluate the efficacy of AZD5423 in patients with mild asthma challenged with an inhaled allergen.
- Trial name
- Allergen (NCT01225549)
- Testing
- AZD5423, Budesonide 200 microgram
- Where
- 4 sites in Canada
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Corona Virus Infection
Glucocorticoid Therapy in Coronavirus Disease COVID-19 Patients
Treatment with glucocorticoids in COVID patients. Low-intervention, phase IV, open-label, randomised, low-intervention clinical trial comparing 2 active treatments.
- Trial name
- NCT04780581
- Testing
- Dexamethasone, Methylprednisolone
- Where
- 4 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Retinal Light Damage, Photic Retinopathy
OCTA Evaluated the Efficacy of Glucocorticoid Retrobulbar Injection in Retinal Photo-injury
The goal of this retrospective observational study is to evaluate the effectiveness of retrobulbar glucocorticoid injection in patients with retinal photo-injury.
- Conditions
- Retinal Light Damage, Photic Retinopathy, Photic Maculopathy
- Trial name
- NCT07869511
- Testing
- retrobulbar injection of glucocorticoid
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoporosis
Comparison of the Effects of 2 Drugs on Lumbar Spine Volumetric BMD in Men With Glucocorticoid-Induced Osteoporosis
The objective of this study is to test the hypothesis that teriparatide is superior to the active comparator in the change from baseline to 18 months of lumbar spine volumetric trabecular bone mineral density (BMD) in males with…
- Trial name
- EuroGIOPS (NCT00503399)
- Testing
- Teriparatide, Risedronate
- Where
- 13 sites in Germany, Greece and 2 more
- Volunteers
- 92 people
- Sponsor
- Eli Lilly and Company
Analgetic, Lung Cancer (NSCLC)
High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in…
- Conditions
- Analgetic, Lung Cancer (NSCLC), Video Assisted Thoracic Surgery (VATS), Glucocorticoid
- Trial name
- DEXTER (NCT07213375)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Rhinosinusitis, Endoscopic Sinus Surgery
Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery
Endoscopic sinus surgery (ESS) is widely considered to be the gold standard in the surgical management of chronic rhinosinusitis (CRS) that has failed maximal medical therapy.
- Trial name
- NCT02182492
- Testing
- Clarithromycin, Glucocorticoid
- Where
- China
- Volunteers
- 187 people
- Sponsor
- Zheng Liu
Myasthenia Gravis
A Study to Compare the Efficacy and Safety of Tacrolimus Capsules in Patient With Myasthenia Gravis
To evaluate the efficacy and safety of tacrolimus capsules in patients with myasthenia gravis who are inadequately treated by glucocorticoid.
- Trial name
- NCT01325571
- Testing
- Tacrolimus capsule
- Where
- 9 sites in China
- Volunteers
- 83 people
- Sponsor
- Astellas Pharma Inc
Giant Cell Arteritis (GCA)
Treatment for Giant Cell Arteritis With Tocilizumab and 8 as Compared to 26 Weeks of Prednisone
The GISCO study plans to determine whether 8-week therapy is just as effective as 26-week cortisone therapy for treating giant cell arteritis with tocilizumab, while using less cortisone.
- Trial name
- GISCO (NCT06833411)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 178 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Polymyalgia Rheumatica
Rituximab Effect on Decreasing glUcoCorticoid Exposition in PolyMyalgia Rheumatica Patients Experiencing a PMR Relapse
Polymyalgia rheumatica (PMR) is prevalent among elderly. Untreated, it leads to major reduction in quality of life. Glucocorticoids are the cornerstone of treatment, but have drawbacks, warranting glucocorticoid sparing…
- Trial name
- REDUCE-PMR-2 (NCT05533164)
- Testing
- Rituximab
- Where
- Netherlands
- Volunteers
- 174 people
- Sponsor
- Sint Maartenskliniek
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD
Comparison of aerosol inhalation and intravenous glucocorticoid in the treatment of severe AECOPD-------Multicenter, prospective, randomized, controlled clinical study
- Trial name
- NCT06189586
- Testing
- aerosol inhalation of glucocorticoids, intravenous injection of glucocorticoids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Yang
Graves Disease, Graves Ophthalmopathy
Liver Function After Intravenous Methylprednisolone Administration
Graves' orbitopathy (GO) is a characterized by orbital soft tissue inflammation and oedema associated with glycosaminoglycan deposition and fibrosis. The most frequent cause is Graves' disease.
- Conditions
- Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure
- Trial name
- NCT03667157
- Testing
- every week IVMP therapy, very high doses IVMP therapy
- Volunteers
- 68 people
- Sponsor
- Medical University of Warsaw