Clinical trials: Glucocorticoids
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Type 2 Diabetes Mellitus
Safety, Tolerability and Efficacy of ISIS-GCCRRx in Type 2 Diabetes
The purpose of this study is to evaluate the efficacy, safety and tolerability of ISIS-GCCRRx in combination with metformin versus placebo + metformin
- Trial name
- NCT01968265
- Testing
- ISIS-GCCRRx
- Where
- 14 sites in Canada, Romania and 1 more
- Volunteers
- 38 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Giant Cell Arteritis (GCA)
Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON)
We propose to analyze the kinetics of the main marker of inflammation in GCA in order to understand its links with initial clinical manifestations and the possible appearance of complications and/or relapses.
- Trial name
- GIDEON (NCT07720804)
- Testing
- Blood tests to measure CRP
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Long QT Syndrome
Phase 1 Study of LQT-1213 in Healthy Adults
This is a single-center, randomized, double-blind, placebo-controlled study to be conducted in 2 parts: single ascending dose (SAD) incorporating a food effect arm and multiple ascending dose (MAD).
- Trial name
- NCT05759962
- Testing
- LQT-1213
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Graft Versus Host Disease, Recurrent Adult Acute Lymphoblastic Leukemia
Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease
This randomized phase III trial is studying low-dose prednisone or methylprednisolone to see how well they work compared with standard-dose prednisone or methylprednisolone in treating patients with newly diagnosed acute…
- Trial name
- NCT00929695
- Testing
- prednisone, methylprednisolone, questionnaire administration
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Fred Hutchinson Cancer Center
Postoperative Pain, Post Operative Analgesia
Continuous Infusion of Dexamethasone Plus Tramadol Adjunct to Morphine PCA After Abdominal Hysterectomy
Dexamethasone has been recognized as an antiemetic agent after surgeries, and the combination of dexamethasone and tramadol remained stable in solution up to 5 days. In addition, i.v.
- Conditions
- Postoperative Pain, Post Operative Analgesia, Patient-Controlled Analgesia, Abdominal Surgeries
- Trial name
- DTMPCA (NCT00564603)
- Testing
- Dexamethasone Sodium Phosphate Injection, 0.9% Saline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Covid-19 Pneumonia
Glucocorticoids in COVID-19 (CORTIVID)
Around 30% of admitted patients with COVID-19 pneumonia develop a hyper-inflammatory state whose progression to an acute respiratory distress syndrome (ARSD) could be prevented by the early initiation of immune-modulatory agents.
- Trial name
- CORTIVID (NCT04438980)
- Testing
- Methylprednisolone
- Where
- 2 sites in Spain
- Volunteers
- 72 people
- Sponsor
- Fundacion Miguel Servet
Metastatic Castration-Resistant Prostate Cancer
Study to Evaluate Exicorilant (CORT125281) in Combination With Enzalutamide in Patients With Metastatic Castration-Resistant Prostate Cancer
This study consists of a dose escalation study with an expansion phase to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD), and preliminary efficacy of exicorilant (CORT125281) in combination…
- Trial name
- NCT03437941
- Testing
- Exicorilant, Enzalutamide
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Corcept Therapeutics
Hypertension
The Risk of Hypertension Associated With Oral Glucocorticoids in Chronic Inflammatory Diseases
Glucocorticoids are widely used for the treatment of chronic inflammatory diseases. In 2008, it was estimated that 0.8% of the United Kingdom adult population had used long-term (≥ 3 months) glucocorticoids, rising to 3% in women…
- Trial name
- NCT03760562
- Testing
- Glucocorticoids
- Volunteers
- 111,804 people
- Sponsor
- University of Leeds
Glucocorticoid Effect
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- Gluco-Feed (NCT05167084)
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Glucocorticoid Induced Hyperglycemia
Comparing the Safety and Efficacy of Insulin GLARGINE and DEGLUDEC in Glucocorticoid Induced HYPERGLYCEMIA in Hospitalized Patients".
Glucocorticoids (GC) represent therapeutic agents of great importance in the treatment and prophylaxis of multiple inflammatory and non-inflammatory conditions.
- Trial name
- NCT07599891
- Testing
- Degludec insulin, Glargine insulin
- Where
- India
- Volunteers
- 79 people
- Sponsor
- Max Healthcare Insititute Limited
Osteoporosis, Sarcopenia
Skeletal Maturation and Endocrine Health in Young Adults
Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors.
- Conditions
- Osteoporosis, Sarcopenia, Obesity, Cardiovascular Diseases
- Trial name
- EPIPEAK (NCT06509776)
- Where
- 9 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Holbaek Sygehus
Mental Retardation, Body Composition, Beneficial
Resistance Training Program, Labor Inclusion, Intellectual Disability
Resistance exercise (RE) has been proposed as a possible strategy for prevention and rehabilitation of diseases. The increase in both muscle strength and the ability to perform tasks of day-to-day work environment and are…
- Conditions
- Mental Retardation, Body Composition, Beneficial, Muscle Weakness
- Trial name
- NCT01456910
- Testing
- Resistance Training Program
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Brasilia
Wegener's Granulomatosis or Microscopic Polyangiitis
A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis
This is a perspective, Phase IV, multi-center, single arm, open-label, interventional study in adult participants with Wegener's granulomatosis (granulomatosis with polyangiitis [GPA]) or microscopic polyangiitis.
- Trial name
- NCT02115997
- Testing
- Methylprednisolone, Prednisone, Rituximab
- Where
- 10 sites in India
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
Advanced Malignancies, Metastatic Cancer
A Study of INCAGN01876 in Participants With Advanced or Metastatic Solid Tumors
This was an open-label, non-randomized Phase 1/2 safety study of INCAGN01876 in participants with advanced or metastatic solid tumors that was conducted in 2 parts.
- Trial name
- NCT02697591
- Testing
- INCAGN01876
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Incyte Biosciences International Sàrl
Proctitis, Proctosigmoiditis
Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to establish the efficacy profile of rectally administered budesonide foam, as compared to an equivalent volume of rectally administered placebo foam over the same dosing schedule, in participants who…
- Trial name
- NCT01008410
- Testing
- Budesonide
- Where
- 63 sites in United States
- Volunteers
- 265 people
- Sponsor
- Bausch Health Americas, Inc.
Alcoholism
Medication Development in Alcoholism: Investigating Glucocorticoid Antagonists
The primary hypotheses under test are that alcohol dependent subjects treated with mifepristone will report decreased craving for alcohol following alcohol exposure in the laboratory and report significantly less drinking under…
- Trial name
- NCT01548417
- Testing
- Korlym (mifepristone), Sugar Pill
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The Scripps Research Institute
Allergic Asthma
Optimization of Asthma Treatment Through Exhaled NO for Increased Asthma-Related Quality of Life (NOAK)
The purpose of this study is to determine whether use of exhaled NO (nitric oxide) to regulate the anti-inflammatory treatment leads to increased asthma-related quality of life in patients with allergic asthma
- Trial name
- NCT00421018
- Testing
- Single corticosteroid inhalers and Singulair
- Where
- Sweden
- Volunteers
- 187 people
- Sponsor
- Karolinska Institutet
Acute Respiratory Failure, Community-Acquired Pneumonia
Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF).
- Trial name
- NCT07357935
- Testing
- Methylprednisolone
- Volunteers
- 500 people
- Sponsor
- Qingyuan Zhan
Prostate Cancer, Insulin Sensitivity
The Effect of Endurance Training in Patients With Prostate Cancer
The aim of the present study is to investigate the effect of endurance on PSA doubling time in prostate cancer patients with an elevation in PSA following radical prostatectomy for localized cancer.
- Conditions
- Prostate Cancer, Insulin Sensitivity, Body Composition, Beneficial
- Trial name
- NCT01584960
- Testing
- endurance training
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Inge Holm