Clinical trials: Glucocorticoids
Glomerular Disease
Effect of Glucocorticoids on Inflammation and Bone Metabolism in Patients With Glomerular Disease
The aim of the study is to assess the influence of high doses of intravenous corticosteroids on plasma inflammation and bone markers in patients with primary glomerular disease.
- Trial name
- NCT04987450
- Testing
- Methylprednisolone, prednisone
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Lodz
Pericarditis Idiopathic Recurrent
Hydroxychloroquine in Colchicine-Resistant Glucocorticoid-Dependent Idiopathic Recurrent Pericarditis
Among patients with colchicine-resistant glucocorticoid-dependent idiopathic RP (idiopathic recurrent pericarditis during at least a second recurrence, having met the 2015 European Society of Cardiology criteria for pericarditis…
- Trial name
- RESTORE (NCT05737680)
- Testing
- Hydroxychloroquine, Colchicine
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hippocration General Hospital
Arthritis, Rheumatoid
COBRA-Slim With or Without Fast Access to TNF Blockade for Remission Induction in Early RA
In the Care in Rheumatoid Arthritis (CareRA) trial (NCT01172639) about 70% of early RA patients are in remission at the 2 year evaluation point independent of the combination scheme used.
- Trial name
- CareRA2020 (NCT03649061)
- Testing
- Etanercept 50 MG/ML, Leflunomide 10 milligram (MG)
- Where
- 19 sites in Belgium
- Volunteers
- 276 people
- Sponsor
- P. Verschueren
Postmenopausal Osteoporosis
A Study of Once Monthly Bonviva (Ibandronate) in Prevention of Glucocorticoid-Induced Osteoporosis.
This 2 arm study will investigate the efficacy and safety of Bonviva (150mg po monthly) in the prevention of glucocorticoid-induced osteoporosis in post-menopausal women.
- Trial name
- NCT00545051
- Testing
- ibandronate
- Where
- 15 sites in Finland
- Volunteers
- 140 people
- Sponsor
- Hoffmann-La Roche
Immunosuppression, Healthy
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
Background: Corticosteroids have been used to treat inflammation and immune system diseases for decades. However, despite their widespread use, there is little information on the specifics of how corticosteroids affect the immune…
- Conditions
- Immunosuppression, Healthy, Healthy Subjects
- Trial name
- NCT01281995
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
DMD-Associated Dilated Cardiomyopathy
TXA127 in Non-Ambulant Patients With DMD Cardiomyopathy
This open-label, single-arm multi-center study studying the safety and efficacy of TXA127 on non-ambulant patients with DMD Cardiomyopathy will comprise of two phases: 1.
- Trial name
- NCT06013839
- Testing
- talfirastide
- Where
- 2 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Constant Therapeutics LLC
Adrenocortical Carcinoma
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
This study will investigate the safety and efficacy of Relacorilant in combination with Pembrolizumab for Patients with Adrenocortical Carcinoma which Produces Too Much Stress Hormone (Cortisol).
- Trial name
- NCT04373265
- Testing
- Relacorilant, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corcept Therapeutics
Thyroid Associated Ophthalmopathies
Efficacy and Safety of Sequential Hormone Therapy and Tetuzumab Therapy in Patients With Moderate to Severe TAO in the Active Stage After Glucocorticoid Treatment.
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter…
- Trial name
- NCT07152366
- Testing
- IBI311, Glucocorticoids
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Changzheng Hospital
Cortisol Resistance, Negative Feedback
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.
- Conditions
- Cortisol Resistance, Negative Feedback, ACTH, Mineralcorticoid
- Trial name
- NCT01294319
- Testing
- Mifepristone, Spironolactone, Combined
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Rheumatoid Arthritis (RA)
Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis
This multicenter, randomized, controlled, single-blind prospective study aims to establish an evidence-based protocol for discontinuing long-term low-dose glucocorticoids in patients with rheumatoid arthritis (RA).
- Trial name
- NCT07227428
- Testing
- Prednisolone
- Volunteers
- 206 people
- Sponsor
- Seoul National University Hospital
Primary Immune Thrombocytopenia
A Study of Romiplostim N01 as the First-line Treatment for Newly Diagnosed Adult Patients With ITP
This study is a multicenter interventional research on the first-line treatment of newly diagnosed adult patients with immune thrombocytopenia (ITP) using romiplostim N01 in combination with glucocorticoids.
- Trial name
- NCT06658834
- Testing
- Dexamethasone Combined with romiplostim N01, Dexamethasone monotherapy
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Glucocorticoid-Associated Osteopenia and Osteoporosis
Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years
This is an extended observation study of a RCT comparing the efficacy of romorozumab and denosumab in high-risk patients using long-term glucocorticoids.
- Trial name
- NCT07757373
- Testing
- Romosozumab, Denosumab
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- Tuen Mun Hospital
Ulcerative Colitis
The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis
The purpose of this study was to evaluate efficacy of cobitolimod treatment at different dose levels and frequencies compared to placebo in patients with moderate to severe left-sided ulcerative colitis.
- Trial name
- CONDUCT (NCT03178669)
- Testing
- cobitolimod
- Where
- 64 sites in Czechia, France and 8 more
- Volunteers
- 213 people
- Sponsor
- InDex Pharmaceuticals
Autoimmune Hemolytic Anemia (AIHA)
A Multicenter, Prospective, Randomized Controlled Study Comparing Glucocorticoid Combined With Sirolimus With Monotherapy of Glucocorticoid in the Treatment of Newly Diagnosed Mild Autoimmune Hemolytic Anemia
This study is a prospective, multicenter, randomized controlled trial. A total of 216 adult patients with newly diagnosed wAIHA were planned to be included and randomly assigned in a 1:1 ratio to the experimental group…
- Trial name
- sirolimus (NCT07518277)
- Testing
- Glucocorticoids
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Chen Miao
Rheumatoid Arthritis
An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Treated With Glucocorticoids
This prospective, observational, multicenter study will assess the efficacy and safety of RoActemra/Actemra (tocilizumab) on the use of glucocorticoids in patients with moderate to severe rheumatoid arthritis and an inadequate…
- Trial name
- NCT01564901
- Where
- 13 sites in Spain
- Volunteers
- 23 people
- Sponsor
- Hoffmann-La Roche
Acute Respiratory Distress Syndrome, Adrenal Insufficiency
Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study is to see if stress doses of hydrocortisone improve early outcome in patients who are in early stage of ARDS and with relative adrenal insufficiency.
- Trial name
- NCT00773058
- Testing
- hydrocortisone
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Immune Thrombocytopenia, Treatment
Daratumumab Versus Rituximab in the Management of Pediatric Primary Immune Thrombocytopenia (ITP)
This randomized, open-label study aim to compare the efficacy and safety of Daratumumab (anti-CD38 monoclonal antibody) with Rituximab in pediatric ITP patients.This study will be conducted in pediatric ITP patients who had not…
- Trial name
- NCT07362238
- Testing
- Rituximab, Daratumumab
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Healthy
CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning
The aim of this project is to study the effects of exogenous glucocorticoid exposure on substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy adults.
- Trial name
- CIRCLE (NCT06035081)
- Testing
- Prednisolone
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Adverse Effect of Glucocorticoids and Synthetic Analogues, Osteoporosis
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
This quality improvement project is aimed at improving health care by identifying low cost strategies to get Rheumatoid Arthritis (RA) patients to more effectively communicate with their physicians about osteoporosis prevention…
- Conditions
- Adverse Effect of Glucocorticoids and Synthetic Analogues, Osteoporosis, Rheumatoid Arthritis
- Trial name
- NCT01378689
- Testing
- Storytelling online video
- Where
- United States
- Volunteers
- 4,659 people
- Sponsor
- University of Alabama at Birmingham
Addison Disease
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
Addison's disease is a rare disease, wherein the adrenals can not produce sufficient steroid hormones (cortisol and aldosterone).
- Trial name
- NCT01271296
- Testing
- Liquorice, Grapefruit Juice
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital