Clinical trials: Glucose Homeostasis
Healthy
Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake
The purpose of this study is to investigate the effect of two weeks clenbuterol/placebo supplementation on skeletal muscle glucose disposal in healthy male volunteers.
- Trial name
- NCT03800290
- Testing
- Clenbuterol Hydrochloride
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes Mellitus (T2DM), Chronic Renal Insufficiency
Study on Improving Blood Glucose Homeostasis With Dorzagliatin Tablets in the Treatment of Type 2 Diabetes Mellitus Patients With Moderate to Severe Chronic Renal Insufficiency
This study aims to evaluate whether dorzagliatin can improve glycemic homeostasis in patients with type 2 diabetes mellitus (T2DM) complicated by chronic renal insufficiency, and to compare the efficacy of dorzagliatin with…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Renal Insufficiency, Chronic Kidney Disease (Stages 3b-5), Glucose Homeostasis
- Trial name
- NCT07786571
- Testing
- Dorzagliatin, Linagliptin
- Where
- China
- Sponsor
- Sun Yat-sen University
Cardiovascular Risk, Hypercholerolemia
Study of the Effects of Yerba Mate on Cardiometabolic Health
The goal of this clinical trial is to learn if consuming a beverage prepared with yerba mate leaves helps to improve blood lipid levels in persons at high cardiovascular risk.
- Trial name
- INFU-SALUD (NCT06729905)
- Testing
- Yerba mate tea, Control drink
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Diabetes Mellitus, Type 2
Effects of a Small Protein and Lipid Preload on Glucose Tolerance in Subjects With Impaired Glucose Homeostasis
The purpose of this study is: to measure the size of the effect on glucose tolerance of a small mixed protein and lipid meal given as a pre-load in individuals with different glucose tolerance status to investigate the underlying…
- Trial name
- NCT02342834
- Testing
- Small mixed protein and lipid meal
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Intermittent Fasting in Shift-work
Time-restricted Eating and Circadian Health in Night Shift Workers
The goal of this clinical trial is to learn about the effect of time-restricted eating (TRE) to 10 hours per day on glucose homeostasis, markers of the circadian system, homeostatic and hedonic regulation of appetite, and…
- Trial name
- FastingClocks (NCT07451132)
- Testing
- Time-restricted eating
- Where
- Chile
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Chile
Healthy
Acute Effects of Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of spices on gene expression of pathways associated with glucose homeostasis, oxidative stress and inflammation, in the postprandial phase in healthy human subjects.
- Trial name
- NCT02479334
- Testing
- Fat challenge breakfast, Fat challenge breakfast+spices, Carbohydrate challenge breakfast
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lund University
Anesthesia Morbidity, Child, Only
Impact of Preoperative Fasting on Intraoperative Glycemic Homeostasis and Enhanced Recovery in Children
In 2018, the main societies of anesthesia (European Society Anaesthesiology, European Society Pediatric Anesthesia, and Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française) changed the current…
- Conditions
- Anesthesia Morbidity, Child, Only, Fasting Hypoglycemia
- Trial name
- GLYNEMCaen (NCT04826627)
- Testing
- glycemia
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Obesity
Acylated Ghrelin Response to Acute Exercise in Obesity
Ghrelin is a GH-secretagogue gastrointestinal hormone that regulates feeding behavior by interacting directly with hypothalamic centers in concert with other negative and permissive neuromodulators.
- Trial name
- aeroghre (NCT00486161)
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Healthy
A Study Evaluating Good Idea on Glucose Homeostasis in a Healthy Population
A crossover design to evaluate the safety and efficacy of GoodIdea TM (trademark) on glucose homeostasis in a healthy population.
- Trial name
- NCT03152682
- Testing
- GoodIdea
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Morbid Obesity
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity
The purpose of this study is to quantify the relative contribution of improved insulin sensitivity and improved insulin secretion to the glycaemic effect of bariatric surgery.
- Trial name
- NCT01063127
- Testing
- Study on insulin sensitivity after diet or bariatric surgery, gastric bypass
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Hyperglycaemia (Non Diabetic), Prediabetes
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover…
- Trial name
- PORK (NCT06025292)
- Testing
- Lean Pork vs Plant-Based Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Glucose Homeostasis
Dipeptidyl Peptidase-4 Inhibition on Glucagon-like Peptide-1 (GLP-1)
This research is being done to evaluate the effect of glucagon-like peptide-1 (GLP-1, a naturally occurring hormone) on insulin release and to examine whether there is extra insulin release when GLP-1 is not allowed to be rapidly…
- Trial name
- NCT00947011
- Testing
- Januvia
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prediabetes
Glycemic Impact of NNS Via the Gut Microbiome
This pilot study will evaluate the feasibility and acceptability of a 30-day sucralose intervention among adults with prediabetes.
- Trial name
- NCT07868432
- Testing
- Sucralose
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Diabetes Mellitus, Type 1
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)
This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG).
- Trial name
- NCT03410277
- Testing
- Experimental hypoglycemia
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Minnesota
Schizophrenia, Antipsychotics
The Study of Atypical Antipsychotics-induced Metabolic Disturbances
Schizophrenia is one of the most severe mental illnesses. The antipsychotic drugs, introduced in early 1950s, have revolutionized the treatment of schizophrenia.
- Trial name
- NCT00937755
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University Hospital
Continuous Glucose Monitoring, Oral Glucose Tolerance
Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control.
- Conditions
- Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
- Trial name
- NCT05441982
- Testing
- Non-Nutritive Sweetener Intake and impact on glucose homeostasis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Polytechnic Institute and State University
Healthy Volunteers
Assessment of Blood Glucose Changes in Healthy Volunteers After BMS-754807 Alone or BMS-754807 With Metformin
The purpose of this study is to assess the effects of Metformin administered over two weeks on the peak plasma glucose concentrations following administration of BMS-754807.
- Trial name
- NHV (NCT01525823)
- Testing
- BMS-754807 (IGR-IR/IR Inhibitor), Metformin
- Where
- Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity Adult Onset
Effects of Electrostimulation on Glycemic Control in Obesity
This study evaluate the effects of muscle electrostimulation (MES) on carbohydrate homeostasis in adult patients with obesity. Its aims are also to evaluate the tolerance of feasibilty and the tolerance of MES and the impact on…
- Trial name
- ElectrOBA (NCT04643899)
- Testing
- Muscle Electrostimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ildys
Metabolic Syndrome X
Effects of Selective Inhibition of Cholesterol Absorption With Ezetimibe on Intestinal Cholesterol Homeostasis in Dyslipidemic Men With Insulin-resistance - a Pilot Study
Ezetimibe has been shown to inhibit cholesterol absorption and several lines of evidence from in vitro systems and animal models suggest that this effect is associated with an increase in low-density lipoprotein (LDL) receptor…
- Trial name
- EZEmRNA (NCT01849068)
- Testing
- Ezetimibe
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University