Clinical trials: Glucose Metabolism
Diabetes, Impaired Glucose Tolerance (IGT)
A Survey on the Rate of Glucose Intolerance in Hong Kong Chinese
Hypothesis: There is a high rate of glucose intolerance among Hong Kong Chinese. The investigators plan to screen Hong Kong Chinese from the community with oral glucose tolerance test (OGTT).
- Conditions
- Diabetes, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG), Glucose Intolerance
- Trial name
- NCT00787215
- Testing
- observational: no treatment involved
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diabetes Mellitus Type 2
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
This randomized, triple-blind clinical trial investigates whether adding truncal vagotomy to Roux-en-Y gastric bypass (RYGB) enhances remission of type 2 diabetes mellitus (T2DM) in patients with obesity.
- Trial name
- VagusSx (NCT07278115)
- Testing
- Roux-en-Y Gastric Bypass plus Truncal Vagotomy, Roux-en-Y Gastric Bypass
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University Research Institute for the Study of Genetic & Malignant Disorders in Childhood
Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy
PRP vs PRP+IVC for Severe nPDR
The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema…
- Conditions
- Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabete Mellitus
- Trial name
- NCT03863535
- Testing
- Conbercept, Panretinal coagulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Type 1 Diabetes
Muscle Oxygenation, Type 1 Diabetes, and Glycated Hemoglobin
Most of the studies concerning aerobic fitness in Type 1 diabetic patients noted a relationship between impaired aerobic fitness and high glycated haemoglobin (HbA1c) levels, reflecting poor long term glycaemic control.
- Trial name
- OXYDIAB (NCT02051504)
- Testing
- Incremental maximal exercise, Oral Glucose Tolerance Test, Muscle biopsy
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Obesity, Overweight
A Study to Investigate the Efficacy and Safety of Elecoglipron in Asian Participants With Obesity or Overweight With or Without Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of elecoglipron compared with placebo adjunct to diet and exercise for weight management, in adult participants living with obesity or overweight with or without…
- Trial name
- Elecoglipron (NCT07775404)
- Testing
- Elecoglipron
- Where
- 49 sites in China, Hong Kong and 3 more
- Volunteers
- 351 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus (T2DM)
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult Males
This study is a single-center, randomized, double-blind, placebo- and active-controlled, parallel-group, single-ascending dose (SAD) design.
- Trial name
- NCT07630233
- Testing
- UBT38006, Insulin Degludec Injection, Insulin Icodec Injection
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Metabolic Syndrome (MetS)
Preliminary Effect of a Health Information Literacy Enhancement Program for Individuals With Metabolic Syndrome
The purpose of this study is to evaluate the preliminary effect of a health-information literacy promotion program for individuals with Metabolic Syndrome (including its subtypes) based on the Health Empowerment Theory.
- Trial name
- NCT07051733
- Testing
- Health Information Literacy Enhancement
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meihua Ji
PCOS, Glucose Metabolism Disorder
Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI
Investigate the effect and mechanism of time-restricted eating (TRE) on the clinical pregnancy rate in women with PCOS and glucose metabolism disorder via IVF/ ICSI.
- Conditions
- PCOS, Glucose Metabolism Disorder, IVF Outcome
- Trial name
- NCT06666933
- Testing
- Time restricted eating, Metformin
- Where
- China
- Volunteers
- 254 people
- Sponsor
- RenJi Hospital
Type1diabetes
4T Sustainability Program
The goal of the 4T program is to implement proven methods and emerging diabetes technology into clinical practice to sustain tight glucose control from the onset of type 1 diabetes (T1D) and optimize patient-reported and…
- Trial name
- NCT06314048
- Testing
- CGM and RPM
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Stanford University
Metabolic Syndrome
Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects
The aim of this study is to explore if a 8-weeks dietary intervention with polyphenols and omega 3 fatty acids (alone or combined) may be effective on postprandial lipids metabolism and other cardiovascular risk factors in people…
- Trial name
- Etherpaths (NCT01154478)
- Testing
- Diet rich in omega-3 fatty acids, Diet rich in polyphenols, Control diet
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Federico II University
Diabetes Mellitus
Interaction Study to Evaluate the Effects of Mefenamic Acid on the Pharmacokinetics and Pharmacodynamics of Sotagliflozin in Healthy Male and Female Subjects
Primary Objective: To assess the effect of multiple dose mefenamic acid on the pharmacokinetics (PK) of sotagliflozin and its metabolite in healthy male and female subjects.
- Trial name
- NCT03070678
- Testing
- Sotagliflozin (SAR439954), Mefenamic acid
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Diabetes Mellitus
The Glycaemic Effect of Isomaltulose Consumption in Healthy Participants
The objective of this study is to determine the glycaemic effect of isomaltulose and sucrose in Chinese, Indian, Malay, and Caucasian individuals.
- Trial name
- NCT03020485
- Testing
- Isomaltulose, Sucrose
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obstructive Sleep Apnea, Insulin Resistance
Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea
The investigators hypothesize that obstructive sleep apnea (OSA) may lead to increased formation/accumulation of advanced glycation ends (AGEs), and that the increase in AGEs is contributed in part by increased insulin…
- Conditions
- Obstructive Sleep Apnea, Insulin Resistance, Endothelial Function, Oxidative Stress
- Trial name
- NCT00942643
- Testing
- CPAP machine
- Where
- Hong Kong
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
PreDiabetes
Examining the Impact of a Self-compassion Intervention on Physical Activity Behaviour Among People With Prediabetes
The investigators plan to examine whether teaching people at risk for type two diabetes to use self-compassion (orientation to care for oneself during difficult situations) helps them self-manage and increase their physical…
- Trial name
- NCT04863235
- Testing
- Control Group, Intervention Group
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Diabetes Mellitus
Effect of Thera-Band Elastic Band-Assisted Progressive Resistance Training on Physical Health in Diabetes Patients with Frailty Syndrome
Goal: The goal of this clinical trial is to evaluate the effectiveness of Thera-Band elastic band-assisted progressive resistance training (PRT) in improving physical health and reducing frailty in older adults with diabetes…
- Trial name
- NCT06658106
- Testing
- Thera-Band Elastic Band-Assisted Progressive Resistance Training, Conventional Diabetes Management
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zhejiang Rongjun Hospital
Diabetes Mellitus, Type 2
A Single Dose Study of LY2189265 in Subjects With Varying Degrees of Hepatic (Liver) Impairment
The primary purpose of this study is to help answer the following research questions, and not to provide treatment for any condition: To evaluate how much of the study drug (LY2189265) is in the blood of participants with varying…
- Trial name
- NCT01253304
- Testing
- LY2189265
- Where
- 2 sites in Germany, Hungary
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase
The purpose of this study is to evaluate consistency of accelerated insulin absorption and onset-of-action and shortened duration of action for bolus insulin infusions after pretreatment with 150 units (U) of Hylenex®…
- Trial name
- NCT01526733
- Testing
- Recombinant human hyaluronidase PH20, Insulin aspart, Insulin lispro
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Halozyme Therapeutics
Diabetes
A Trial to Investigate Different Needle Features Assessed by Comparing Insulin Aspart Pharmacokinetic Profiles
This trial is conducted in Europe. The aim of the trial is to investigate different needle features assessed by comparing insulin aspart Pharmacokinetics profiles (the exposure of the trial drug in the body)
- Trial name
- NCT02594033
- Testing
- insulin aspart
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Novo Nordisk A/S
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
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