Clinical trials: Glucose Metabolism
Insulin Resistance
Effect of Radiofrequency on Insulin Resistence in Obese Post Menopansal Women
insulin resistance as the prime factor linking visceral obesity with adverse metabolic changes. Analysis of abdominal obesity by imaging studies have generally reached the conclusion that it is the excess of intra-abdominal or…
- Trial name
- NCT05818293
- Testing
- radiofrquency device
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Type 2 Diabetes, Insulin Resistance
Effect of Low-Glycemic Index Mediterranean Diet on AGEs
Advanced glycation end products (AGE) result from a chemical reaction between the carbonyl group of reducing sugar and the nucleophilic NH2 of a free amino acid or a protein; lysine and arginine being the main reactive amino…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Cardiovascular Disease
- Trial name
- Nutri_AGEs (NCT02353416)
- Testing
- Low Glycemic Index Mediterranean Diet, INRAM Guidelines' diet
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Obesity and Overweight, Diabetes Mellitus
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults.
- Conditions
- Obesity and Overweight, Diabetes Mellitus, Weight Loss, Behavior Change
- Trial name
- FAM WEL B-ing (NCT06724406)
- Testing
- Family Skills Training Session Quantity: 5, Family Skills Training Session Mode: In-person, Family Skills Training Content: Communication
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes
Meal Timing on Postprandial Glucose, Insulin and GLP-1 in Type 2 Diabetes
Enhanced insulin and GLP-1 postprandial response after morning meal versus evening meal, might be underlying explanation of the beneficial effect of eating breakfast with reduced dinner vs skipping breakfast on glycemic control…
- Trial name
- GLP-1inT2D (NCT01977833)
- Testing
- High Calorie Breakfast (BTdiet), High Caloric Dinner (DTdiet)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel Aviv University
Self Care
Evaluation of the Eversense Continuous Glucose Monitoring System in Type I Diabetic Youth
The purpose of this clinical investigation is to provide pilot clinical data to direct pivotal study development for the pediatric indication of the Senseonics Continuous Glucose Monitoring System (CGM) measurements when compared…
- Trial name
- FNH (NCT03815552)
- Testing
- Eversense Continuous Glucose Monitoring
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Cushing Disease
Long-Term Follow-Up of Survivors of Pediatric Cushing Disease
Background: The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems.
- Trial name
- NCT03831958
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diabetes Mellitus
Efficacy and Safety of Alogliptin in Subjects With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety of alogliptin, once daily (QD), in adults with type 2 diabetes.
- Trial name
- NCT00286455
- Testing
- Alogliptin
- Where
- 67 sites in United States, Argentina and 16 more
- Volunteers
- 329 people
- Sponsor
- Takeda
Type 1 Diabetes Mellitus
A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd also known as retogatein compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous…
- Trial name
- DIAGNODE-3 (NCT05018585)
- Testing
- Recombinant human glutamic acid decarboxylase (rhGAD65) formulated in Alhydrogel®, Colecalciferol 2000 IU
- Where
- 60 sites in United States, Czechia and 7 more
- Volunteers
- 321 people
- Sponsor
- Diamyd Medical AB
Diabetic Polyneuropathy, Diabetes Mellitus, Type 2
Driving with Neuropathy
This study is a proof-of-concept randomised controlled trial (RCT). The goal of the study is to investigate the effectiveness of a feedback intervention to improve use of the accelerator pedal in patients driving with diabetes…
- Trial name
- NCT06739135
- Testing
- Visual feedback training
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Manchester Metropolitan University
Diabetic Macular Edema
Pilot Study for the Evaluation of Intravitreal Infliximab in the Treatment of Diabetic Macular Edema
The purpose of this study is to determine if intravitreal infliximab is a safe and effective treatment for macular edema secondary to diabetes.
- Trial name
- NCT00959725
- Testing
- Infliximab (intravitreal, 2.0mg/0.05ml)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypothalamic Obesity, Diabetes Mellitus
Effects of Exenatide on Obesity and/or Diabetes Mellitus Due to Hypothalamic Damage
The purpose of this study is to examine the effect of exenatide on body weight and glycemic control in subjects with obesity and/or diabetes mellitus due to hypothalamic damage.
- Trial name
- NCT01783717
- Testing
- Exenatide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Diabetes Mellitus, Type 2
Ursodeoxycholic Acid as add-on Therapy in Type 2 Diabetes Mellitus
Diabetes mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia and abnormalities in carbohydrate, fat, and protein metabolism. It is one of the most prevalent metabolic disorders globally.
- Trial name
- NCT05902468
- Testing
- Ursodeoxycholic acid
- Where
- 2 sites in Egypt
- Volunteers
- 88 people
- Sponsor
- Tanta University
Hypertriglyceridemia, Insulin Resistance
Predictors of Response to Fenofibrate
Fenofibrate is one of the best options for treating hypertriglyceridemia. In the majority of patients, fenofibrate lowers triglycerides (TG) by 24-55% and improves HDL- and LDL-cholesterol.
- Trial name
- PreFar (NCT01023750)
- Testing
- Fenofibrate
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes
Vitamin D Supplementation to Patients With Type 2 Diabetes
The purpose of the study is to evaluate if supplementation with vitamin D in a dose of 40.000 IU per week will result in improved metabolic control in patients with type 2 diabetes.
- Trial name
- NCT00400491
- Testing
- Cholecalciferol (vitamin D)
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Diabetes Mellitus, Type 2
Web-based Insulin Titration - An Efficacy Study
The main objective of the study is to determine whether an intensive web-based titration system, called PANDIT (Patient Assisting Net-based Diabetes Insulin Titration), is effective in improving glycaemic control in patients with…
- Trial name
- NCT01715090
- Testing
- Web-based insulin titration
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 1 Diabetes
Islet Allotransplantation in Type 1 Diabetes
Islet transplantation can provide physiologic insulin replacement to patients with type 1 diabetes without the complications associated with whole pancreas transplantation.
- Trial name
- NCT01705899
- Testing
- Human Pancreatic Islets
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Homocystine; Metabolic Disorder
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan
Raised plasma Homocysteine (Hcy) was 1st proposed as a cause of vascular pathology in patients with inherited disorders of Homocysteine metabolism.leading to the hypothesis that individuals with slight to moderate elevated levels…
- Trial name
- NCT05011032
- Testing
- Homocysteine
- Where
- Pakistan
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Diabetes, Nerve Injury
Molecular Mediators of Nerve Injury Signaling
Specific proteins and other signaling molecules are increased and decreased following nerve injury. Some of these are important in producing pain or explaining why pain persists after traumatic nerve injuries or in disease states…
- Conditions
- Diabetes, Nerve Injury, Chronic Neuropathic Pain
- Trial name
- NCT01437332
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Diabetes Mellitus, Type 2
A Clinical Study to Assess the Efficacy and Safety of Vildagliptin in Patients With Type 2 Diabetes
This study was not conducted in the United States. The purpose of this study was to assess the safety and effectiveness of a number of doses of vildagliptin, an unapproved drug, in the treatment of people with type 2 diabetes.
- Trial name
- NCT00238498
- Testing
- vildagliptin
- Volunteers
- 291 people
- Sponsor
- Novartis
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT)
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities…
- Conditions
- Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG)
- Trial name
- NCT02969798
- Testing
- Dapagliflozin, Saxagliptin, Pioglitazone
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
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