Clinical trials: Glucose Metabolism
Diabetes Mellitus
Mobile Phone Personalized Intervention for Diabetes
With the development of economy and change of lifestyles, it is characterized that there is a dramatic increase of diabetes in China.
- Trial name
- NCT02124408
- Testing
- Personalized Behavioral Intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ningbo Beilun District Traditional Chinese Medicine Hospital
Type 2 Diabetes, Pre-diabetes
Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance
The incidence rate of type 2 diabetes in Thai populations is high and increasing every year. Cardiovascular disease is the main complication of this disease, which has been defined as an important cause of death among Diabetic…
- Conditions
- Type 2 Diabetes, Pre-diabetes, Insulin Resistance, Cardiovascular Risk
- Trial name
- NCT01052025
- Testing
- Curcumin
- Where
- Thailand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Srinakharinwirot University
Type2 Diabetes Mellitus, Hyperglycemia
Heart Rate During Exercise in Type 2 Diabetes
Exercise training is a cornerstone for the prevention and treatment of metabolic disorders and associated cardiometabolic complications such as type 2 diabetes mellitus (T2D) and hypertension.
- Conditions
- Type2 Diabetes Mellitus, Hyperglycemia, Heart Rate, Exercise Training
- Trial name
- HRinT2DM (NCT03917576)
- Testing
- Behavioral, Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad de Los Lagos
Healthy Women, Diet Habit
Diets, Metabolic Profile and Gut Microbiota Among Indonesian Women in Minangkabau and Sundanese-ethnic Community
Many provinces in Indonesia have some well known traditional foods that are widely consumed, but it remains unknown whether traditional ethnic dietary patterns can confirm healthy diets.
- Conditions
- Healthy Women, Diet Habit, Bifidobacterium, Inflammation
- Trial name
- NCT03412617
- Volunteers
- 360 people
- Sponsor
- Rina Agustina
Polycystic Ovary Syndrome
Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)
Our hypothesis is that hyperinsulinemia increases the renal clearance of D-chiro-inositol (DCI) in women with polycystic ovary syndrome (PCOS) and that this leads to a reduction in circulating insulin-stimulated…
- Trial name
- PCOS (NCT00868140)
- Testing
- pioglitazone
- Where
- 2 sites in United States, Venezuela
- Volunteers
- 51 people
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 1, Type1diabetes
Group Education Trial to Improve Transition in Type 1 Diabetes
The investigators will conduct a randomized controlled trial (RCT) to examine group education visits as an innovative and potentially cost-effective approach to transition care delivery, that can be easily integrated into usual…
- Conditions
- Diabetes Mellitus, Type 1, Type1diabetes, Insulin Dependent Diabetes
- Trial name
- GET-IT-T1D (NCT03703440)
- Testing
- Active arm, Control arm
- Where
- 2 sites in Canada
- Volunteers
- 212 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Hyperglycemia
Durban Diabetes Study:A Study of the Epidemiology of Diabetes Mellitus in Urban South Africans of African Descent (DDS)
Type 2 diabetes (T2D) is an emerging epidemic in sub-Saharan Africa, with an estimated prevalence of 6%. With around seven million cases of T2D in 2000, it is anticipated that over 18 million Africans will have the disease by…
- Conditions
- Diabetes Mellitus, Hyperglycemia, Hereditary Diseases, Glucose Intolerance
- Trial name
- DDS (NCT02416440)
- Testing
- blood sample
- Where
- South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Type 1 Diabetes, Hypoglycemia
Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diabetes
The aim of the study is to evaluate the efficacy, safety and feasibility of outpatient-utilization of low-dose dasiglucagon administered via a multi-dose reusable pen injector in preventing and treating mild hypoglycemia in…
- Trial name
- NCT04764968
- Testing
- Dasiglucagon
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Foot Ulcer, Diabetes Mellitus
The Prevalence of Foot Complaints/Problems and Ulcers in a Pre-dialysis Population
Diabetes mellitus is one of the main causes of chronic kidney disease (CKD) and an increased risk of foot complications is seen in patients suffering from both DM and CKD.
- Conditions
- Foot Ulcer, Diabetes Mellitus, Chronic Kidney Diseases, Pre-dialysis
- Trial name
- NCT04784650
- Testing
- Pre-dialysis population
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cancer Survivor, Diabetes Mellitus
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant
This pilot clinical trial studies computed tomography (CT) scans and biomarker analysis in diagnosing coronary artery disease (CAD) in patients who have undergone a stem cell transplant but have no symptoms of CAD.
- Conditions
- Cancer Survivor, Diabetes Mellitus, Hypertension
- Trial name
- NCT02077218
- Testing
- computed tomography, cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Type2 Diabetes, Coronary Heart Disease
Coronary Artery Calcium-guided Primary Prevention of Major Coronary Heart Disease in Asymptomatic Diabetes
To evaluate benefits of primary prevention of major coronary heart disease for asymptomatic coronary artery disease in type 2 diabetes mellitus based on the coronary artery calcium score Our proposal 1.
- Trial name
- NCT05267990
- Testing
- Multi-Detector Computed Tomography
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- JuFeng, Hsiao
Pre Diabetic, Hyperglycaemia (Non Diabetic)
Diabetes Prevention by Group Intervention and CGM Use in Pre-diabetic Adults
This study is being done to find better ways to help people with prediabetes prevent or delay the development of type 2 diabetes.
- Trial name
- CGM (NCT07543068)
- Testing
- Combines group sessions and CGM-based behavioral feedback
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sam Houston State University
Prediabetes, Hypertension
Intervention With a GABA Supplement in Prediabetics
In this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (GABA) supplementation on glucose tolerance and cardiovascular health will be assessed in…
- Trial name
- NCT04303468
- Testing
- GABA
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 1
REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)
The trial is conducted in the United Kingdom (UK), Australia, Canada, Denmark and the Netherlands. The aim is to test whether 3 years treatment with metformin added to titrated insulin therapy (towards target HbA1c 7.0%/53…
- Trial name
- REMOVAL (NCT01483560)
- Testing
- Metformin
- Where
- 24 sites in Australia, Canada and 3 more
- Volunteers
- 493 people
- Sponsor
- University of Glasgow
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-402)
This is a multicenter, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with type 2 diabetes mellitus (T2DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01278485)
- Testing
- Sulphonylurea, Metformn
- Volunteers
- 726 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Empowerment and Support for the Diabetic Patient
CHANGE-D objectives are to evaluate to what extent personal coaching for healthy lifestyle and treatment adherence improves clinical outcomes among uncontrolled diabetic patients.
- Trial name
- CHANGE-D (NCT02179385)
- Testing
- Health Coaching
- Volunteers
- 300 people
- Sponsor
- Clalit Health Services
Liver Diseases
Metformin in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)
The purpose of this study is to examine the effect of metformin on biochemical and histological findings in NAFLD patients with insulin resistance syndrome.
- Trial name
- NCT00247117
- Testing
- Metformin
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Kaplan Medical Center
Plexus Choroideus, Metabolic Syndrome
Choroid Plexus Dysfunction in Neurological Diseases
Cerebral folate deficiency (CFD), a partially treatable condition defined by a low folate cerebrospinal fluid (CSF) concentration, can be linked to genetic defects of folate metabolism or be secondary to various diseases without…
- Trial name
- PLEXFOLD (NCT06403189)
- Testing
- Biologic samples and MRI
- Where
- 2 sites in France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
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