Clinical trials: Glucose Metabolism
Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS)
IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion
The goal of this study is to learn how two treatments-adrenalectomy (surgical removal of an adrenal gland) and semaglutide (a medication used for weight management)-affect insulin resistance and cortisol regulation in adults with…
- Conditions
- Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol Excess
- Trial name
- IMPACT-MACS (NCT07361874)
- Testing
- Intervention 1: Adrenalectomy, Intervention 2: Semaglutide
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes Mellitus
Single Hormone Closed Loop Study With PDT Sensor
The study described within this protocol is designed to test a single hormone closed-loop algorithm for managing blood glucose in type 1 diabetes using insulin only and a new device for measuring glucose continuously in the…
- Trial name
- NCT03528174
- Testing
- Artificial Pancreas Control system (APC), Pacific Diabetes Technologies CGM Insulin Infusion system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Kidney Transplant, Type 2 Diabetes
Sitagliptin Treatment in Patients With Type 2 DM After Kidney Transplant
This study is designed to look at the effect sitagliptin has on tacrolimus and sirolimus drug levels in kidney transplant patients. It is also designed to look at the side effects experienced in the transplant population.
- Trial name
- NCT00466518
- Testing
- Administration of sitagliptin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Ischemia Limb, Diabete Mellitus
Comparative Study of Negative-Pressure Wound Therapy Integrated With Silver Nanoparticle Spray Versus Negative-Pressure Wound Therapy in Post-Revascularization Diabetic Foot Wound Management
This was a prospective, parallel-group, randomized controlled trial conducted at the Vascular Surgery Department of Kafrelsheikh University Hospital, Egypt.
- Trial name
- SNIPS-FOOT (NCT07147790)
- Testing
- After successful revacularization, We will categorize patients into two groups : groups A (The patient's wound will be cleaned and irrigated with silver nanoparticle spray, then we will cover the woun, Silver Nanoparticles Irrigant
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
Diabetes
Quality of Life and Treatment Satisfaction of People With Type 2 Diabetes: A European Survey
The present European survey seeks to assess quality of life and satisfaction with treatment in people with T2DM and to appreciate disease and treatment variables including hypoglycaemia and level of glycaemic control.
- Trial name
- PANORAMA (NCT00916513)
- Where
- 302 sites in France, Germany and 6 more
- Volunteers
- 5,926 people
- Sponsor
- AstraZeneca
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Diabetes, Hypertension
Genetics of Type 2 Diabetes Among Han Chinese
Objectives: To conduct a genome-wide association study (GWAS) to identify susceptibility genetic variants for diabetes among Han Chinese.
- Trial name
- NCT00837408
- Where
- China
- Volunteers
- 2,379 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Leukemia, Lymphoma
Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)
The goal of this clinical research study is to learn if intense management and control of blood sugar levels during treatment for acute lymphocytic leukemia, Burkitts lymphoma, or lymphoblastic lymphoma will result in decreased…
- Trial name
- NCT00500240
- Testing
- Insulin Glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetes Mellitus, Type 1
Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes Mellitus.
testing of autonomic function and relationship with exercise and Qol in diabetic patients and controls
- Trial name
- NCT03481374
- Testing
- autonomic function testing
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Obstructive Sleep Apnea, Metabolic Syndrome
Effects of CPAP on Cardiovascular Risk in Obstructive Sleep Apnea (OSA) and Metabolic Syndrome
The increased risk of atherosclerotic morbidity and mortality in patients with obstructive sleep apnea (OSA) has been linked to arterial hypertension, insulin resistance, systemic inflammation, and oxidative stress in previous…
- Trial name
- NCT00635674
- Testing
- CPAP device - REMstar Plus, Respironics, Murrysville, USA
- Where
- Slovakia
- Volunteers
- 32 people
- Sponsor
- Pavol Jozef Safarik University
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Type 2 Diabetes
GLucobay M OBservation Study for Efficacy and Safety in Treatment of Type-2 Diabetes Patients
An observational and multicenter study to assess the effectiveness and safety of Glucobay®- M under daily life treatment of type-2 diabetes patients.The study objectives are to investigate the effectiveness and safety of…
- Trial name
- GLOBE (NCT01219582)
- Testing
- Glucobay M (Acarbose/Metformin, BAY81-9783)
- Where
- India
- Volunteers
- 9,364 people
- Sponsor
- Bayer
Type 2 Diabetes Mellitus
Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of Canagliflozin (TA-7284) in combination with Insulin in patients with type 2 Diabetes for 16 weeks administration.
- Trial name
- NCT02220920
- Testing
- Canagliflozin (TA-7284), Insulin
- Where
- 7 sites in Japan
- Volunteers
- 146 people
- Sponsor
- Tanabe Pharma Corporation
Type 2 Diabetes Mellitus
Prediction of Findings From the Ongoing CAROLINA Trial Using Healthcare Database Analyses
This cohort study was initiated to predict the findings of CAROLINA trial in a real world setting using electronic claims data from insurance databases with results anticipated prior to the completion of CAROLINA.
- Trial name
- NCT03648424
- Where
- United States
- Volunteers
- 48,262 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot, Diabetes
Predictors of Skin Temperature, Plantar Pressure and Ulceration in Diabetic Foot Patients.
Diabetes is a chronic disease with increasing prevalence worldwide with a high burden to individuals and the society and it is expected to be the 7th leading cause of death in 2030.
- Trial name
- NCT03254095
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Radiocontrast-Induced Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease
Contrast-induced nephropathy (CIN) is the third most common cause of hospital acquired acute kidney injury, accounting for 10% of all cases. The pathophysiology of CIN is unclear. Possible mechanisms involve 1.
- Conditions
- Radiocontrast-Induced Nephropathy, Chronic Kidney Disease, Diabetes Mellitus
- Trial name
- NCT00808795
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Type 2 Diabetes
The Diabetes Aerobic and Resistance Bands Exercise (DARE-Bands) Trial
BACKGROUND Resistance exercise training with free weights or weight machines clearly improves glucose (sugar) control in type 2 diabetes (T2D).
- Trial name
- DARE-Bands (NCT02009995)
- Testing
- Aerobic Training (AT), AT plus Primarily Home-Based Resistance Band Training
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University of Calgary
Type 2 Diabetes, Hypertension
Impact of Clinical Pharmacist-Led Intervention on Management of Diabetic Hypertensive Patients in Eastern Nepal
Diabetic-Hypertensives are at a higher risk of premature microvascular and macrovascular complications than diabetes alone. Proper lifestyle management, diet, disease monitoring, and medication adherence is essential in achieving…
- Trial name
- NCT05707481
- Testing
- Clinical Pharmacist-Led Educational Intervention
- Where
- Nepal
- Volunteers
- 92 people
- Sponsor
- Chettinad Academy of Research and Education (Deemed to be University)
PreDiabetes
Efficacy and Safety of Digital Therapeutic in Adults With Prediabetes
The study aims to evaluate the efficacy and safety of a digital therapeutic (TH-001) for adult individuals with prediabetes.
- Trial name
- NCT05668819
- Testing
- TH-001
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Tesu Saglik Teknolojileri A.S.
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