Clinical trials: Glucose Metabolism
Hypercholesterolemia, Coronary Heart Disease
Assessment of the Efficacy of Rosuvastatin in Patient Groups With a Dissimilar Risk Profile in an Observational Study (HEROS)
In an observational multi-centre study (HEROS), the effects of starting treatment with rosuvastatin were assessed, on low-density lipoprotein cholesterol (LDL-C) goal achievement, in patients with a dissimilar high-risk profile…
- Conditions
- Hypercholesterolemia, Coronary Heart Disease, Peripheral Vascular Disease, Cerebrovascular Accident
- Trial name
- HEROS (NCT00660764)
- Testing
- Rosuvastatin
- Sponsor
- AstraZeneca
Chronic Hepatitis C, Insulin Resistance
NIDDM and IR in Combination Therapy for CHC
The influence of insulin sensitivity and glucose tolerance on the effects of antiviral therapy for HCV remains unclear. The aim of the present study was (1) To elucidate the clinical and virological factors associated with…
- Trial name
- NCT00687999
- Testing
- pegylated interferon alpha and ribavirin
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Diabetes Mellitus
The Body Constitution and Quality of Life of Diabetic
Diabetic Mellitus is the fifth cause of death by the report of Department of Health in 2008, and it often cause the severity of other chronic diseases.
- Trial name
- NCT01060332
- Testing
- Body Constitution Questionnaire
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Sleep Apnea Syndromes, Lung Diseases
Family Linkage Study of Obstructive Sleep Apnea (OSA) in Iceland
To study the genetic basis of obstructive sleep apnea using a genealogical approach.
- Conditions
- Sleep Apnea Syndromes, Lung Diseases, Insulin Resistance
- Trial name
- NCT00083798
- Volunteers
- 2,843 people
- Sponsor
- University of Pennsylvania
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Curcumin on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function According to rs35652124 in Diabetic Nephropathy
The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide. Epidemiological studies have shown that DM is the leading cause of chronic kidney disease (CKD) in patients…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Type 2, Polymorphism
- Trial name
- CURCUNRF2 (NCT03262363)
- Testing
- Curcumin/NFE2L2 A>G
- Where
- Mexico
- Volunteers
- 176 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Kidney Transplant
Tacrolimus and Risk Factors for Glucose Metabolism Disorders in Kidney Transplant Patients
Many people who receive a kidney transplant develop problems with how their body processes sugar (glucose). This includes conditions like prediabetes and diabetes, which can lead to more health issues, such as heart problems and…
- Trial name
- TARGET (NCT06833463)
- Testing
- LCP Tacro (tacrolimus)
- Where
- 6 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Chiesi Poland Sp. z o.o.
Diabetes
Healthy Living for You
The goal of the study is to conduct the Healthy Living with Diabetes (HLWD) program among Black individuals in a culturally appropriate manner. This study will involve 24-30 participants in total.
- Trial name
- NCT05917093
- Testing
- Culturally tailored HLWD
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Type 1
Physical Activity Monitoring Paediatric Type 1 Diabetes
Physical activity (PA) can have positive health outcomes for children with type 1 diabetes (T1DM), yet being physically active can have unwanted side effects due to fluctuations in blood glucose (BG) level.
- Trial name
- NCT03144869
- Testing
- physical activity monitor and feedback
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Sheffield Hallam University
Type 1 Diabetes
Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- PSO4 (NCT01823341)
- Testing
- Pump suspension algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Jaeb Center for Health Research
Type 2 Diabetes Mellitus
Evaluation of the Metformin Effect on Methylglyoxal in Patients With Type 2 Diabetes
This study is designed to investigate the effects of metformin, a commonly prescribed first line medication for diabetes and recommended for prediabetes, on the levels of the potentially tissue damaging reactive product (MG) in…
- Trial name
- MET (NCT02548741)
- Testing
- Metformin Hydrochloride (500-mg capsule), Glucometer (One Touch glucometer), strips and lancets, Urine container for 24-hour urine collection
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Type 2 Diabetes Mellitus
Antioxidant Effects of Pomegranate Juice Versus Placebo in Adults With Type 2 Diabetes Mellitus
This is a research study designed to look at how pomegranate juice (or a placebo juice) affects the body through the measurement of specific biomarkers, which are indicators of health.
- Trial name
- NCT00668954
- Testing
- Pomegranate Juice
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Effects of Bashan on Glucose in Type 2 Diabetes Patients and Its Related Mechanisms
The study aimed to observe the effect of targeted diet on blood glucose improvement in type 2 diabetic patients by continuous glucose monitoring and to explore the possible mechanism of targeted diet on blood glucose improvement…
- Trial name
- NCT05333822
- Testing
- Bashan, water
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongda Hospital
Periodontitis, Diabetes
Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the effectiveness of local delivery of Lactobacillus reuteri probiotic on periodontitis patients with type 2 diabetes mellitus, as an adjunct to non-surgical periodontal treatment.
- Trial name
- NCT07598656
- Testing
- Lactobacillus reuteri DSM 17938, Distilled water
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Obese With Comorbidities, Obese Patients (BMI ≥ 30 kg/m²)
A Study to Investigate the Efficacy and Safety of Two Different Doses of Twice Daily Distal Jejunal-release Dextrose Beads Formulations Combined With a Gel Composition Compared to Placebos in Obese Subjects With Weight Related Comorbidities
The goal of this randomized, double-blind, placebo-controlled, phase IIa study is to demonstrate superiority on body weight reduction of two different doses of twice daily distal jejunal-release dextrose beads formulations (APHD…
- Trial name
- NCT07008456
- Testing
- APHD-012, APHD-002, APHP-012
- Where
- 6 sites in Georgia
- Volunteers
- 102 people
- Sponsor
- Aphaia Pharma US LLC
Diabetic Foot Ulcer
AmnioExcel® Plus vs SOC in the Management of Diabetic Foot Ulcers
This is a prospective, multicenter, randomized, parallel-group Trial comparing the outcomes associated with the use of AmnioExcel® Plus Placental Allograft Membrane (AmnioExcel® Plus) used in conjunction with Standard of Care…
- Trial name
- NCT05024656
- Testing
- AmnioExcel Plus Amniotic Membrane, Standard of Care
- Sponsor
- Integra LifeSciences Corporation
Type 1 Diabetes, Type 2 Diabetes
A Performance Evaluation of the Harmony 1 Sensors in Adults and Pediatrics
The purpose of this study is to demonstrate the performance of the Harmony 1 Sensor in subjects age 2 - 75 years
- Trial name
- NCT02456922
- Testing
- Harmony 1 Sensor
- Sponsor
- Medtronic MiniMed, Inc.
Type 2 Diabetes
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)
The main purpose of this study is to investigate the efficacy and safety of Tirzepatide monotherapy in Chinese participants with Type 2 Diabetes.
- Trial name
- NCT05963022
- Testing
- Tirzepatide
- Where
- 28 sites in China
- Volunteers
- 206 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus
Sotagliflozin Multiple-dose Study in Healthy Chinese Subjects
Primary Objective: To assess the safety and tolerability of sotagliflozin after a multiple oral dose administration in Chinese healthy subjects.
- Trial name
- NCT03909451
- Testing
- Sotagliflozin (SAR439954)
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sanofi
Obesity, Diabetes Mellitus, Type 2
Slowly Digestible Carbohydrates and the Ileal Brake
The ileal brake is a feedback mechanism controlling stomach-mediated transit of a meal, for which gastric emptying can be used as an indicator.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
- Trial name
- NCT03630445
- Testing
- Isomaltooligosaccharides (IMOs), Xtend® sucromalt, Combination of IMOs and Xtend® sucromalt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Overweight and Obesity, Insulin Resistance
Insulin and Muscle Fat Metabolism
Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans.
- Conditions
- Overweight and Obesity, Insulin Resistance, Metabolic Disease, Mitochondrial Metabolism
- Trial name
- NCT04759872
- Testing
- Hyperinsulinemic-euglycemic Clamp
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Oregon State University
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