Clinical trials: Glucose Metabolism
Diabetes Mellitus
An Educational Intervention for Type 2 Diabetes Patients
Diabetes is common, it is expensive, and it is a chronic condition. Estimates put the prevalence of diabetes at almost 20 percent in VA patients and the prevalence of diabetes in the VA is higher among racial and ethnic…
- Trial name
- ACTIVet (NCT01671345)
- Testing
- Intervention Video, Control
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Diabetes Mellitus
Remote Multichannel Monitoring of Patients With Chronic DIseAses Using Speech technoLogies Based On Artificial intelliGence
DIALOG is a study to assess the efficacy and safety of remote patient monitoring using virtual operator voice technologies and a business intelligence (BI) system for timely detection, prevention of early complications, worsening…
- Conditions
- Heart Failure, Diabetes Mellitus, Arterial Hypertension, Lymphoproliferative Disease
- Trial name
- DIALOG (NCT06644339)
- Testing
- Voice assistant
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Diabetes Mellitus, Type 2
Aronia in the Type 2 Diabetes Treatment Regimen
In a triple-crossover study, the effect aronia consumption on type 2 diabetes will be examined. 48 type 2 diabetes patients need to complete the trial.
- Trial name
- NCT04647175
- Testing
- Fermented aronia, Aronia
- Where
- Denmark
- Volunteers
- 58 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, Type 2, Depression
Program ACTIVE: Phase 2
The present study seeks to tailor the original Program ACTIVE (Adults Coming Together to Increase Vital Exercise) to meet the cultural norms and needs of adult Black men with comorbid Type 2 diabetes and depression by using focus…
- Trial name
- NCT04369001
- Testing
- Community-Based Exercise, Cognitive Behavioral Therapy
- Sponsor
- University of Michigan
Metabolic Syndrome, Insulin Resistance
Effect of Rosiglitazone on the Vascular Biology of Human Fat Tissue
Insulin resistance is a common condition that can lead to type 2 diabetes. One of the commonly prescribed diabetes medications, called rosiglitazone, works by decreasing insulin resistance.
- Trial name
- RAPA (NCT01150981)
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Hemodialysis, Diabete Mellitus
Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia Trial
This randomized controlled trial will investigate whether use of continuous glucose monitoring (CGM) vs. usual care with self-monitored blood glucose 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves…
- Conditions
- Hemodialysis, Diabete Mellitus, Continuous Glucose Monitoring
- Trial name
- CONDOR (NCT05509881)
- Testing
- Continuous glucose monitoring (CGM), Usual care (Self-monitored blood glucose)
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, Irvine
Diabetes, Diabetes Mellitus, Type 1
Comparison of 2 NovoFine® Needles on the Reflux of Insulin
This trial is conducted in Europe. This trial aims to ensure that there is no substantial clinically relevant difference between the two Novo Nordisk needles NovoFine® 6 x 0.30 mm and NovoFine® 8 x 0.30 mm on reflux of insulin…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Delivery Systems
- Trial name
- NCT00872560
- Testing
- NovoFine® needle 6 mm, NovoFine® needle 8 mm
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Novo Nordisk A/S
Septic Shock, Adverse Event
Early Versus Conventional Cessation of Hydrocortisone in Septic Shock
Septic shock is one of the causes of death in ICU and hospital. Refractory shock is the problem which healthcare providers should recognize though it is difficult to handle with.
- Conditions
- Septic Shock, Adverse Event, Hydrocortisone, Hyperglycemia
- Trial name
- CESSHYDRO (NCT05818826)
- Testing
- normal saline solution, Hydrocortisone and normal saline solution
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Diabetes Mellitus, Prediabetes / Type 2 Diabetes
Chronic Dorzagliatin on Insulin and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes
A total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. Eligible participants will undergo hyperglycemic-clamp/oral glucose tolerance at baseline and after 4…
- Trial name
- NCT06671340
- Testing
- Dorzagliatin
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Elaine Chow
Type 2 Diabetes
Metformin Hydrochloride and Empagliflozin Tablets in the Treatment of Type 2 Diabetes
The main objective of this study is to evaluate the efficacy and safety of Metformin Hydrochloride and Empagliflozin Tablets in the treatment of type 2 diabetes in real-world clinical settings.
- Trial name
- NCT07003191
- Testing
- Metformin Hydrochloride and Empagliflozin tables (Fixed-Dose Combination)
- Where
- China
- Volunteers
- 2,600 people
- Sponsor
- Sun Yat-sen University
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
Diabetes, Liver
Foxtail Millet Based Dietary Intervention for Postprandial Glycemic Management Among Obese Diabetic Patients
This randomized controlled trial evaluated the effectiveness of foxtail millet (Setaria italica (L.) P. Beauv.) muffin supplementation on postprandial glycemic management among obese patients with type 2 diabetes mellitus.
- Conditions
- Diabetes, Liver, Lipid Profiles
- Trial name
- NCT07699250
- Testing
- T0, T1, T2
- Where
- Pakistan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Ketoacidosis
Expected Normal Ketone Values After Very Low and Bariatric Surgery
The investigators propose a multicenter prospective study in patients undergoing either an elective bariatric procedure or an elective benign procedure, including laparoscopic/open cholecystectomy, laparoscopic/open hiatus hernia…
- Trial name
- NCT05442918
- Where
- Australia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- St Vincent's Hospital Melbourne
Diabetes
Precise Treatment of Prediabetes and Stage 1 Hypertension
To identify the occurrence of diabetes, hypertension, cardiovascular and cerebrovascular events and all-cause death in patients with baseline prediabetes and stage1 hypertension after 18 years follow up.
- Trial name
- NCT04529590
- Where
- China
- Volunteers
- 2,004 people
- Sponsor
- Ruijin Hospital
Type 2 Diabetes, Obesity
Effect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants with Type 2 Diabetes
The study seeks to explore the cardiovascular effects of co-agonism at the glucagon and (glucagon-like peptide-1) GLP-1 receptor. Glucagon and exenatide will be intravenously infused into participants with type 2 diabetes (T2DM).
- Trial name
- COCONUT (NCT04307797)
- Testing
- 0.9% Sodium-chloride, Exenatide (50ng/min for 30 minutes loading followed by 25ng/min maintenance) and glucagon 12.5ng/kg/min, Glucagon 12.5ng/kg/min and 0.9% saline
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus
Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery.
- Conditions
- Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus, Insulin, Ketones
- Trial name
- WBH003 (NCT07186660)
- Testing
- CIR-0602K
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Diabetes type2
The Canadian Diabetes Prevention Program
According to Diabetes Canada ("DC"), in 2015, the estimated prevalence of prediabetes in Canada (>20 years of age) is 5.7 million people (22.1%). This rate is estimated to increase to 6.4 million people (23.2%) by 2025.
- Trial name
- CDPP (NCT05784220)
- Testing
- DPP Curriculum for Lifestyle Intervention
- Where
- Canada
- Volunteers
- 2,174 people, healthy volunteers welcome
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Mitochondria, Metformin
Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy
he goal of this clinical trial is to compare the mitochondrial redox effects of imeglimin versus metformin monotherapy in adults with newly diagnosed Type 2 diabetes mellitus who are treatment-naive.
- Trial name
- MIRROR-DM (NCT07436182)
- Testing
- Imeglimin, Metformin 1000 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Mansoura University
Cardio Vascular Disease, Metabolic Syndrome (MetS)
Norwegian Mental Illness Heart Health Study
Norwegian patients with severe mental illnesses (SMI), such as schizophrenia spectrum or bipolar disorder, lose on average 10 years of life compared to mentally healthy individuals. Much of this gap is due to heart disease.
- Conditions
- Cardio Vascular Disease, Metabolic Syndrome (MetS), Severe Mental Disorder, Schizophrenia and Schizophrenia Spectrum Psychosis
- Trial name
- NORMI-Heart (NCT07085923)
- Testing
- Lifestyle Intervention
- Where
- Norway
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Madeleine Elisabeth Angelsen
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