Clinical trials: Glucose Metabolism
Diabetes
Glucose Measurement Using Microneedle Patches
This study will compare three glucose measurement techniques among diabetic children and adolescents. The study seeks to determine if a microneedle patch (made from biocompatible polymers or metal), versus a lancet or intravenous…
- Trial name
- GUMP (NCT02682056)
- Testing
- Microneedle patch, Intravenous (IV) catheter, Lancet
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Emory University
Hyperglycemia, Metformin
Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery
Evaluation of the effect of peri-operative continuation of oral metformin therapy on the incidence of perioperative hyperglycemia compared to standard preoperative cessation of oral metformin therapy 24h before surgery.
- Conditions
- Hyperglycemia, Metformin, Type 2 Diabetes, Hyperlactatemia
- Trial name
- NCT04284722
- Testing
- Metformin Hydrochloride
- Volunteers
- 400 people
- Sponsor
- Kepler University Hospital
Diabetes Mellitus, Cardiovascular Diseases
Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery
Preliminary studies have shown that people with diabetes who undergo heart surgery may have a higher risk of developing cognitive functioning problems, including memory problems, than people without diabetes who undergo heart…
- Trial name
- NCT00836329
- Testing
- Intensive Glucose Management, Traditional Glucose Management:
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes Mellitus
Dose-finding of PB-119 Administered Subcutaneously Once-weekly Versus Placebo in Drug-naïve T2DM Subjects
This is a multicenter, randomized, double-blind, placebo-controlled, parallel dose cohort, multiple dose study to evaluate the efficacy, safety, and tolerability of different doses of PB-119 in drug-naïve subjects with T2DM.
- Trial name
- NCT03520972
- Testing
- PB-119 75ug, PB-119 150ug, PB-119 200ug
- Where
- China
- Volunteers
- 251 people
- Sponsor
- PegBio Co., Ltd.
Diabetes Mellitus Type 2
Adipose Tissue Imaging in Type 2 Diabetes
The metabolic function of different white adipose tissue depots in the body and its role in the development of type 2 diabetes (T2D) remains unclear.
- Trial name
- ATI-DM2 (NCT02528695)
- Testing
- 18F-FDG PET/CT, euglycemic clamp, hypoglycemic clamp
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes
Fluid Resuscitation for Pediatric Diabetic Ketoacidosis
Randomized trial to determine if the volume of fluid administration in pediatric patients with DKA impacts the rate of normalization of serum bicarbonate, pH as well as the length of treatment
- Trial name
- NCT01701557
- Testing
- slow fluid rate, fast fluid rate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
School Centered Telemedicine Program for Children With Type 1 Diabetes Mellitus
The purpose of this study is to determine if using school-based telemedicine for diabetes support and education in students with type 1 diabetes in grades K-8 can lead to improvement in control of diabetes and improved…
- Trial name
- NCT00566475
- Testing
- telemedicine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- State University of New York - Upstate Medical University
Type 2 Diabetes Mellitus
A Randomized Cross-over Trial of the Postprandial Effects of Three Different Diets in Patients With Type 2 Diabetes
The trial will study the acute metabolic effects of three different types of diet: low-fat diet, low-carbohydrate diet and Mediterranean diet.
- Trial name
- NCT01522157
- Testing
- Low-fat Diet, Low-carbohydrate Diet, Mediterranean Diet
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- Vårdcentralen Lyckorna
Diabetes Mellitus, Type 2
Glycemic Response in Persons with Type 2 Diabetes
This will be a randomized crossover design with nutrition supplement interventions.
- Trial name
- NCT04413357
- Testing
- Balanced Nutritional Drink, Diabetes Specific, Balanced Nutritional Drink (DMA), Diabetes Specific, Balanced Nutritional Drink DMB
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Société des Produits Nestlé (SPN)
Metabolic Syndrome, Coronary Heart Disease
Cognition and Exercise Training
The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral…
- Conditions
- Metabolic Syndrome, Coronary Heart Disease, Chronic Heart Failure
- Trial name
- COGNEX-2 (NCT01906957)
- Testing
- high intensity interval training (HIIT), moderate intensity continuous exercise training
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Glucose Metabolism Disorders (Including Diabetes Mellitus), Lipid Metabolism Disorders
CBD, Nutrient Metabolism and Energy Intake
CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Lipid Metabolism Disorders, Appetitive Behavior
- Trial name
- NCT05618756
- Testing
- Acute oral CBD supplementation
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Type 2 Diabetes, Dyslipidemia
Effects of Metformin on Hepatic FFA Metabolism
Background: Metformin treatment has beneficial effects on both glucose and lipid metabolism. Whereas there is general agreement that the blood glucose lowering effect of metformin results from inhibition of hepatic…
- Trial name
- NCT01729156
- Testing
- Metformin
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lars Christian Gormsen
Metabolic Syndrome X
The Improvements of Dietary Supplement of Black Rice on Metabolic Syndrome
The purpose of this study is to thoroughly investigate how the interaction between black rice and human gut microbiota affects metabolic diseases, this study will recruit patients with Metabolic Syndrome (MS) and provide them…
- Trial name
- IDSBRMS (NCT02407522)
- Testing
- Black rice, follow-up
- Volunteers
- 101 people
- Sponsor
- Sun Yat-sen University
Type 1 Diabetes Mellitus
Triple Therapy in T1DM
To assess whether the addition of dapagliflozin to semaglutide and insulin (triple therapy) improves glycemic control in patients with type 1 diabetes compared with semaglutide and insulin (dual therapy) and insulin only…
- Trial name
- NCT03899402
- Testing
- Insulin, Semaglutide, Dapagliflozin
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Type 2, Diabetic Retinopathy
Exploring the Effectiveness of AI Generative Models for Diabetic Patients
We plan to explore the usability of Generative AI-Chatbot for Diabetic Patient
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Retinopathy, Diabetes
- Trial name
- NCT05883072
- Testing
- Exploring AI-Chatbot
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Pakistan Council of Scientific and Industrial Research
Diabetes Mellitus, Type 2
The Effect of Alogliptin on Pulmonary Function in Obese Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy
Objective: To observe the effect of alogliptin combined with metformin on pulmonary function in obese patients with type 2 diabetes inadequately controlled by metformin monotherapy (500 mg, bid po, for at least 3 months), and…
- Trial name
- NCT02798172
- Testing
- Alogliptin and Metformin
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Fourth People's Hospital of Shenyang
Diabete Type 2
Risk Factors for Developing Peak Plantar Pressure During Walking in the Diabetic Patients
The goal of this observational study is to investigate the clinically convenient dynamic and static measurement parameters to identify related risk factors of developing high peak plantar pressure during walking in the type-2…
- Trial name
- NCT07164495
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Diabetes, Diabetes Mellitus, Type 2
Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes Mellitus
This trial is conducted in the United States of America (USA). The aim of this trial is to compare the efficacy and safety of two different formulations of insulin degludec (IDeg) in subjects with type 2 diabetes.
- Trial name
- BEGIN™ (NCT01364428)
- Testing
- insulin degludec
- Where
- 45 sites in United States
- Volunteers
- 373 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
Phase III Study for Glimepiride + Metformin Hydrochloride (Amaryl M) Slow Release (SR)
Primary: To show the equivalence in terms of efficacy glycated hemoglobin (HbA1c) of glimepiride/metformin slow-release combination tablet (Amaryl M SR 2/500) once daily compared with fixed-dose glimepiride/metformin combination…
- Trial name
- NCT00437554
- Testing
- Glimepiride
- Where
- South Korea
- Volunteers
- 188 people
- Sponsor
- Handok Inc.
Diabetes
Evaluation of an Investigational Blood Glucose Monitoring System
The purpose of this study was to determine if untrained subjects who have diabetes can operate the Investigational Blood Glucose Monitoring System (BGMS) and obtain valid glucose results.
- Trial name
- NCT01859494
- Testing
- NINJA 3 Investigational Blood Glucose Monitoring System
- Where
- 2 sites in United States
- Volunteers
- 219 people
- Sponsor
- Ascensia Diabetes Care
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