Clinical trials: Glucose Metabolism
Gestational Diabetes, PreDiabetes
Maternal Health Diabetes Prevention Study
The aim of this project is to use the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to collect pilot data on the implementation of a Diabetes Prevention Program-like intervention in the Women, Infants…
- Conditions
- Gestational Diabetes, PreDiabetes, Hyperglycemia, Glucose Intolerance During Pregnancy
- Trial name
- NCT05343494
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tulane University
Type 2 Diabetes Mellitus, Obesity
Effect of Vitamin D Supplementation on the Metabolic Control and Body Composition of Type 2 Diabetes Subjects in Ajman (UAE)
The incidence of type 2 diabetes mellitus and obesity is increasing at an alarming rate both nationally and worldwide. Accumulating evidence suggests that serum cholecalciferol levels may be inversely related to the prevalence of…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Hypovitaminosis D
- Trial name
- VDIS (NCT02101151)
- Testing
- Vitamin D3(cholecalciferol)
- Where
- United Arab Emirates
- Volunteers
- 87 people
- Sponsor
- Rashid Centre for Diabetes and Research
Chronic Kidney Disease
A Phase 1, Open-label Safety Study of NKA in Patients With Type 2 Diabetes
The purpose of this study is to determine if selected renal cells, obtained by biopsy from a patient with chronic kidney disease (CKD) and Type 2 Diabetes (i.e., autologous cells) can be safely implanted back into the patient.
- Trial name
- NCT02008851
- Testing
- Neo-kidney augment
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Tengion
Obesity, Metabolic Syndrome X
Exercise Training and Hepatic Metabolism in Overweight/Obese Adolescent
The HEPAFIT Study aims to examine whether a 6-months physical education program has benefits on hepatic metabolism and cardiovascular health as well as on selected physical fitness and mental health outcomes among adolescent…
- Conditions
- Obesity, Metabolic Syndrome X, Lipid Metabolism Disorders, Body Composition, Beneficial
- Trial name
- HEPAFIT (NCT02753231)
- Testing
- Low physical activity program, High physical activity program, Low and High physical activity program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Diabetes Mellitus, Type 2, Diabetes Complications
The Use of Cilostazol in Patients With Diabetic Nephropathy
Patients with type 2 diabetes have a long duration of disease for the development of complications. Among all complications, microangiopathic complications are major causes of mortality and morbidity in diabetic patients.
- Trial name
- NCT00272831
- Testing
- Cilostazol
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
PreDiabetes, Kidney Transplantation
Exercise and Prediabetes After Renal Transplantation
The present clinical trial, EXPRED-II, is the continuation of EXPRED-I (NCT04489043). Objective: to evaluate the feasibility of exercise in the reversibility of prediabetes after transplantation, as a first step to prevent…
- Trial name
- EXPRED-II (NCT06576531)
- Testing
- Therapeutic exercise
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of La Laguna
Insulin Resistance, Type 2 Diabetes
Adiponectin and Ethnic Differences in Insulin Resistance
The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects.
- Trial name
- NCT01831102
- Testing
- none- observational study
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Antioxidant Treatment of Type 2 Diabetes
This study examines whether an antioxidant taken orally will improve glucose tolerance and insulin secretion in type 2 diabetic subjects.
- Trial name
- NCT00609102
- Testing
- n-aceylcysteine
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Diabetes, Diabetes Mellitus, Type 2
Comparison of Two Biphasic Insulin Aspart Treatments in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to compare two different active treatment regimens of biphasic insulin aspart in subjects with type 2 diabetes.
- Trial name
- NCT01520753
- Testing
- biphasic insulin aspart 70, biphasic insulin aspart 50
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Novo Nordisk A/S
Metabolic Syndrome
The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome
The hypothesis of this study is that the daily consumption of 2 medium-sized pears for twelve weeks will improve blood pressure, lipid profiles, glycemic control and insulin resistance, inflammatory and oxidative status in men…
- Trial name
- NCT02228837
- Testing
- Pear
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida State University
Diabetes, Hypertension
Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
Recent evidence suggests that increased levels of a circulation fat (free fatty acids or FFAs) can cause high blood pressure and cardiac complications. Intralipid is the only type of fat approved by the FDA for clinical use.
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- NCT00989339
- Testing
- Twenty-four Hour TPN and Saline Infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Type 2 Diabetes
Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Saxagliptin as Monotherapy in Pediatric Patients With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy, safety, tolerability, of Saxagliptin in pediatric patients with type 2 diabetes.
- Trial name
- NCT01204775
- Testing
- Saxagliptin, Metformin IR, Metformin (Active Rescue)
- Where
- 16 sites in United States, Russia and 2 more
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Diabetic Foot Ulcer
Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With An Uninfected Foot Ulcer
The purpose of this study is to determine the safety and efficacy of the topical gentamicin collagen sponge (gentamicin sponge) combined with standard of care (daily wound care, off-loading, diabetic control and debridement by a…
- Trial name
- NCT00658957
- Testing
- gentamicin-collagen sponge
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Innocoll
Hyperglycemia
A Clinical Trial Evaluating TQF3250 Capsules in Healthy Adult Subjects
TQF3250 capsule is a biased GLP-1 (glucagon-like peptide-1) receptor agonist developed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Trial name
- NCT07327281
- Testing
- TQF3250 capsule
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Diabetes Mellitus, Type 1
The Link Between "Time In Range" Versus HbA1c and the Presence of Chronic COmplications in Type 1 Diabetes: a Longitudinal Study
HbA1c is currently the only metric of glucose control showing an association with chronic complications of type 1 diabetes mellitus (T1D).
- Trial name
- TIRCO (NCT05530369)
- Volunteers
- 479 people
- Sponsor
- University Hospital, Antwerp
Peritoneal Dialysis, Pioglitazone
Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients
1. Background:Cardiovascular disease (CVD) is the major cause of mortality in peritoneal dialysis (PD) patients, in whom it is partly attributable to a higher prevalence of dysmetabolism.
- Conditions
- Peritoneal Dialysis, Pioglitazone, Hypertriglyceridemia, Insulin Resistance
- Trial name
- NCT01258322
- Testing
- Pioglitazone
- Volunteers
- 70 people
- Sponsor
- Huashan Hospital
Colorectal Cancer
Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia
The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by…
- Trial name
- NCT02032953
- Testing
- Travasol (amino acid injection), Insulin
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Type 1
Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus
The purpose of the study is to compare Humalog (Insulin lispro)-recombinant human hyaluronidase (rHuPH20) or Novolog (Insulin aspart)-rHuPH20 to Humalog (Insulin lispro) for the treatment of Type 1 Diabetes Mellitus (T1DM) in…
- Trial name
- NCT01194245
- Testing
- Insulin lispro, recombinant human hyaluronidase PH20, Insulin aspart
- Where
- 19 sites in United States
- Volunteers
- 135 people
- Sponsor
- Halozyme Therapeutics
Diabetes Mellitus, Type 2
Health Coaching, Continuous Glucose Monitoring and AI Mobile App in Diabetes
Lifestyle change is key to diabetes management but there are limited resources and time to support patients in improving lifestyle behaviour in the current healthcare system.
- Trial name
- NCT06028139
- Testing
- Continuous glucose monitoring and health coaching, EMPOWER mobile app
- Where
- 3 sites in Singapore
- Volunteers
- 400 people
- Sponsor
- Singapore General Hospital
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