Clinical trials: Glucose Metabolism
Diabetes, Diabetes Mellitus, Type 1
Comparison of NPH Insulin and Insulin Detemir in Children and Adolescents With Type 1 Diabetes
This trial is conducted in Europe. The aim of this research is to compare the efficacy and safety of treatment with NPH insulin and insulin detemir.
- Trial name
- NCT00435019
- Testing
- insulin detemir, insulin NPH, insulin aspart
- Where
- 43 sites in Bulgaria, Czechia and 9 more
- Volunteers
- 348 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Safety and Efficacy of BGP-15 in Patients With Type 2 Diabetes Mellitus
This is a safety and dose finding efficacy study to evaluate the effects of BGP-15 over the dose range of 100 mg/day to 400 mg/day.
- Trial name
- NCT01069965
- Testing
- BGP-15 100 mg QD, BGP-15 100 mg BID, BGP-15 200 mg QD
- Where
- 30 sites in United States, Germany and 1 more
- Volunteers
- 196 people
- Sponsor
- N-Gene Research Laboratories, Inc.
Diabetes Mellitus Type 1
Measuring and Monitoring Blood Glucose Levels Utilizing Non-invasive Blood Glucose Monitoring Device
Adequate glycemic control in patients with Diabetes Mellitus (DM) is a desired therapeutic goal that can be achieved with a true non-invasive device offering the likelihood of continuous glucose monitoring.
- Trial name
- NCT01508065
- Testing
- Glucometer CGM-305
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- GlucoVista
Diabetes, Obesity
Tu Salud Si Cuenta: UT Community Outreach Program for Community-based Diabetes Prevention and Control.
Building from existing intervention strategies designed for the Mexican American population entitled Tu Salud Si Cuenta(TSSC) or Your Health Matters.
- Trial name
- UTCO (NCT01168765)
- Testing
- Tu Salud Si Cuenta Behavioral Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score
(Pakistan Diabetes Prevention Program PDPP)
The Karachi-based Pakistan Diabetes Prevention Study aims to address key issues in the prevention of type 2 diabetes. Approximately 20,000 people From four communities will be screened for diabetes risk factors using a…
- Trial name
- PDPP (NCT01530165)
- Testing
- Life style intervention
- Where
- Pakistan
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Type 2 Diabetes, Liver Disease
Digital Behavioral Therapy to Reduce Diabetes and Liver Disease Risk
This clinical trial aims to find out if a digital behavioral program, delivered through the SIPPA digital therapeutics app, can help improve blood sugar control and lower the risk of liver fibrosis in adults with type 2 diabetes…
- Trial name
- SIPPA-QH_HHC-2 (NCT07032311)
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- SIPPA Solutions INC
Type 2 Diabetes
Effect of High-intensity Low-volume Training on Insulin Sensitivity in Type 2 Diabetes
High intensity interval training is applied for several diseases. Hypothesis: High intensity interval training improves insulin sensitivity in patients with type 2 diabetes.
- Trial name
- HIT (NCT02039934)
- Testing
- High intensity interval training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Diabetes Mellitus, Type 2
Efficacy and Safety of Lobeglitazone Versus Sitagliptin
Efficacy and Safety of Lobeglitazone versus Sitagliptin in inadequately controlled by Metformin alone Type 2 Diabetes mellitus Patients with Metabolic syndrome.
- Trial name
- NCT02480465
- Testing
- Lobelitazone 0.5mg, Sitagliptin 100mg
- Where
- South Korea
- Volunteers
- 248 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Blood Glucose Decrease During and After Defined Individual Exercise in T1DM
Exercise in Type 1 Diabetes Mellitus
Background: During and after exercise there is a twofold stimulation of glucose transporter type 4 in type 1 diabetes mellitus (T1DM) caused by an exogenous insulin injection and muscle contraction.
- Trial name
- ExT1DM (NCT02075567)
- Testing
- Experimental
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Insulin Resistance, Ethanol
The Effects of Ethanol on Intestinal Permeability and Gut Hormones
The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.
- Conditions
- Insulin Resistance, Ethanol, Incretin Effect
- Trial name
- NCT03348371
- Testing
- Ethanol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabete Mellitus, Insulin Dependent Diabetes
Therapeutic Education Consultations With Diabetic Patients Treated With Intensified Insulin Therapy
Diabetes is a chronic condition that affects around 8% of the French population, and is associated with severe complications. Maintaining a constant blood glucose level of between 0.7 and 1.80 g/l is the day-to-day objective of…
- Trial name
- DIABETE COACH (NCT06167499)
- Testing
- Diabetes Therapeutic Education conducted by nurses
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Hopital Nord Franche-Comte
Type 2 Diabetes
Self-care Behaviors of Type 2 Diabetes Mellitus Patients
The goal of this observational study is to explore the experience of the chronic disease, with a particular focus on self-care, in adults with type 2 diabetes mellitus.
- Trial name
- NCT07042399
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
Type2diabetes, Mild Cognitive Impairment
Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
This is a single-arm feasibility study employing a pre-post design with a 12-week intervention period. The study utilizes a telehealth-assisted home-based resistance exercise program, with a structured progression from supervised…
- Conditions
- Type2diabetes, Mild Cognitive Impairment, Age-related Cognitive Decline
- Trial name
- NCT07416799
- Testing
- Progressive Exercise Program (12 Weeks)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
Patients with diabetes have high blood sugar levels (hyperglycemia) because pancreatic beta-cells no longer produce sufficient insulin.
- Trial name
- NCT00813228
- Testing
- Sitagliptin (Januvia)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Healthy, Metabolic Syndrome
Study of Metabolic Homeostasis in Chinese
In this open-label, acute intervention study, we will recruit 120 sex-matched participants aged 20-70 years (100 normal or overweight/obese subjects and 20 Mets subjects).
- Trial name
- NCT04173728
- Testing
- Standard mixed macronutrients tolerance test
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Type 2 Diabetes
SWIFT: Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy
The overall goal of the Study of Women, Infant Feeding and Type 2 Diabetes after GDM pregnancy (SWIFT) is to determine the relation of longer and more intensive lactation, as compared to formula feeding, on progression to…
- Trial name
- SWIFT (NCT01967030)
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2
Diabetes Resistance Training Adaptations in Elderly
This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2.
- Trial name
- DRTAE (NCT02548000)
- Testing
- Resistance training, Stretching control
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetes, Diabetes Mellitus, Type 2
Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment
This trial is conducted in Europe. The aim of the trial is to investigate the pharmacokinetics (the exposure of the trial drug in the body), safety and tolerability of oral semaglutide (NNC0113-0217) in subjects with mild…
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT02016911
- Testing
- semaglutide
- Where
- 6 sites in Czechia, Poland and 1 more
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Propranolol in Treating Hypoglycemia Unawareness
Impaired awareness of hypoglycemia is common in type 1 diabetes (T1DM) patients. Impaired hypoglycemia awareness increases severe hypoglycemia risk by six-fold.
- Trial name
- NCT03161964
- Testing
- Propranolol 80 Mg Oral Capsule, Extended Release
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anu Sharma
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