Clinical trials: Glucose Metabolism Disorders
Diabetes, Hyperglycemia
The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery
The purpose of this study was to investigate the effects of three different glycemic treatment conditions (tight, conventional, and standard) in the intraoperative period on: 1) postoperative surgical site infections, and 2)…
- Conditions
- Diabetes, Hyperglycemia, Surgical Site Infection
- Trial name
- NCT01831154
- Testing
- Tight Glycemic, Conventional Glycemic, Standard Glycemic
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- James A. Haley Veterans Administration Hospital
HIV/AIDS, Noncommunicable Diseases
Harambee: Integrated Community-based HIV/NCD Care & Microfinance Groups in Kenya
The objective of this project is to demonstrate the effectiveness and longer-term sustainability of a differentiated care delivery model for improving HIV treatment outcomes.
- Conditions
- HIV/AIDS, Noncommunicable Diseases, Hypertension, Diabetes
- Trial name
- NCT04417127
- Testing
- Integrated Community-Based (ICB) Care, Group-level Microfinance
- Where
- Kenya
- Volunteers
- 1,200 people
- Sponsor
- Brown University
Diabetic Kidney Disease
Impact of Vitamin D on Diabetic Kidney Disease in African Americans
This purpose of this project is to evaluate the effectiveness of vitamin D supplementation over 12 months in vitamin D deficient African American adults with type 2 diabetes.
- Trial name
- NCT01214356
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Diabetes
Evaluation of the A1CNow+ Test Kit
The purpose of this study was to assure that consumers can successfully use the new version of A1CNow+ along with revised instructional materials.
- Trial name
- NCT00798486
- Testing
- A1C Test Kit
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ascensia Diabetes Care
Obesity, Type2diabetes
The Effects of Glucagon on Hepatic Metabolism
Whether impaired postprandial glucagon suppression in prediabetes and T2DM is an attempt to overcome resistance to glucagon's actions on hepatic AA catabolism, a defect in α-cell function, or a combination of both are important…
- Conditions
- Obesity, Type2diabetes, NAFLD
- Trial name
- NCT05500586
- Testing
- Glucagon response study
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Adrian Vella
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prevention of New Onset Diabetes Among Kidney Transplant Patients
A Clinical Trial to Prevent New Onset Diabetes After Transplantation
Specific Aim 1: To determine the clinical efficacy of early initiation of insulin therapy in decreasing the incidence of NODAT among de novo kidney transplant patients with manifested post-transplant hyperglycemia during the…
- Trial name
- ITP-NODAT (NCT01683331)
- Testing
- Insulin treatment for hyperglycemia
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- University of Michigan
Type 1 Diabetes Mellitus
Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver
The purpose of this study is to learn if giving multiple doses of a hormone called glucagon can cause a major decrease in liver glycogen (animal starch).
- Trial name
- NCT01986231
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Legacy Health System
Type 2 Diabetes
Safety and Efficacy of Once-Daily KRP-104 in Type 2 Diabetics With Inadequate Glycemic Control on Metformin Alone
The purpose of this study is to assess the safety and effectiveness of KRP-104 on glycemic control in patients with type 2 diabetes inadequately controlled on metformin alone.
- Trial name
- Synergy104 (NCT00995345)
- Testing
- KRP-104
- Where
- 45 sites in United States, Argentina and 5 more
- Volunteers
- 403 people
- Sponsor
- ActivX Biosciences, Inc.
Type 2 Diabetes
Glycemic Effect of Colesevelam HCl (Welchol) in Patients With Type 2 Diabetes
The purpose of this study is to obtain continuous glucose monitoring (CGM) data from individuals taking Welchol compared to placebo.
- Trial name
- NCT00993824
- Testing
- colesevelam HCl
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Type 2, Penile Diseases
Penile Length Restoration in Men With Diabetes Mellitus, Type II
The objective of the current study is to evaluate the efficacy of a novel penile traction device in restoring lost penile length in men with type 2 diabetes.
- Trial name
- NCT03756688
- Testing
- RestoreX PTT - 6 months, RestoreX PTT - 3 months
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2
Pharmacokinetics and Pharmacodynamics Trial With Linagliptin (BI 1356) 5mg in African American Type 2 Diabetic Patients
The objective of this trial is to investigate the pharmacokinetics and pharmacodynamics of linagliptin (BI 1356) 5 mg administered orally in patients with Type 2 diabetes mellitus of African American origin.
- Trial name
- NCT00935220
- Testing
- linagliptin QD (once daily) for 7 days
- Where
- 6 sites in United States
- Volunteers
- 41 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes (Treated With Exenatide or Other Oral Antidiabetic Therapies), Healthy Subjects (Treated With no Diabetes Therapies)
A Retrospective Cohort Study of Acute Pancreatitis in Relation to Use of Exenatide and Other Antidiabetic Agents
The purpose of this research was to assess the absolute and relative incidence of acute pancreatitis in persons initiating exenatide compared with persons initiating a different antidiabetic agent, and secondarily, persons…
- Trial name
- NCT01077323
- Testing
- exenatide, Other antidiabetic therapies, No diabetes therapy
- Where
- United States
- Volunteers
- 363,766 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
A Study to Test the Effectiveness and Safety of MK0893 in Combination With Other Drugs Used to Treat Type 2 Diabetes (0893-015)
This study will test the effectiveness and safety of treatment with MK-0893 in combination with other drugs commonly used to treat type 2 diabetes for a duration up to 13 weeks.
- Trial name
- NCT00631488
- Testing
- MK-0893, Sitagliptin, Metformin
- Volunteers
- 146 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 1 Diabetes
Medtronic Treat to Range (TTR) Closed-Loop Control
The purpose of this study is to evaluate a treat-to-range automated insulin management system using continuous glucose monitoring (CGM) and subcutaneous insulin pump infusion in individuals with type 1 diabetes.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Metabolic and Nutritional Disorders
- Trial name
- NCT01490151
- Testing
- TTR controller (Medtronic)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus in India
The main purpose of this study is to evaluate safety of dulaglutide in participants with type 2 diabetes mellitus in India.
- Trial name
- NCT05659537
- Testing
- Dulaglutide
- Where
- 7 sites in India
- Volunteers
- 212 people
- Sponsor
- Eli Lilly and Company
Gestational Diabetes
Sleep Duration in Women With Previous Gestational Diabetes
Women with a history of gestational diabetes (GDM) are at high risk of developing diabetes in the future. Sleep disturbances are emerging as risk factors for incident diabetes.
- Trial name
- NCT03638102
- Testing
- Sleep extension, Healthy living
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus, Hypertension
A Quality Improvement Process to Support Delivery of Cardiovascular Care in Community Mental Health Organizations
This pilot study will examine whether an implementation strategy will improve delivery of evidence-based care for cardiovascular risk factors for people with serious mental illness.
- Conditions
- Diabetes Mellitus, Hypertension, Dyslipidemias
- Trial name
- NCT04696653
- Testing
- Comprehensive Unit Based Safety Program (CUSP)
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus
The purpose of the study is to compare Humalog (Insulin lispro)-recombinant human hyaluronidase (rHuPH20) or Novolog (Insulin aspart)-rHuPH20 to Humalog (Insulin lispro) for the treatment of Type 1 Diabetes Mellitus (T1DM) in…
- Trial name
- NCT01194245
- Testing
- Insulin lispro, recombinant human hyaluronidase PH20, Insulin aspart
- Where
- 19 sites in United States
- Volunteers
- 135 people
- Sponsor
- Halozyme Therapeutics
Diabetes, Diabetes Mellitus, Type 2
Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 Diabetes
This trial is conducted in Asia. The trial aims to investigate if the blood glucose control of biphasic insulin aspart 50 is at least as effective as treatment with biphasic insulin aspart 30 both in combination with metformin.
- Trial name
- NCT00627445
- Testing
- biphasic insulin aspart 30, metformin, biphasic insulin aspart 50
- Where
- China
- Volunteers
- 441 people
- Sponsor
- Novo Nordisk A/S
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